Hitoshi Sasano
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View article: Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases Open
Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly inv…
View article: Corrigendum to “Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial” [Allergol Int 74 (2025) 274-82]
Corrigendum to “Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial” [Allergol Int 74 (2025) 274-82] Open
View article: ERC/Mesothelin Is Associated with the Formation of Microvilli on the Mesothelium and Has Limited Functional Relevance Under Physiological Conditions
ERC/Mesothelin Is Associated with the Formation of Microvilli on the Mesothelium and Has Limited Functional Relevance Under Physiological Conditions Open
In adults, expressed in renal cancer (ERC)/mesothelin is exclusively expressed in the mesothelial cells lining the pleural, pericardial, and peritoneal cavities, yet its function under physiological conditions is unknown. To explore this, …
View article: Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo)
Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo) Open
Mepolizumab effectiveness was demonstrated in a broad range of patients including those with RCT exclusion criteria, who had significant disease or OCS burden. These findings may explain the consistent results between RCT and real-world st…
View article: Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment
Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment Open
The study observed a yearlong increase in mepolizumab concentrations, particularly in those with response, indicating a potential mepolizumab surplus. Correlations between mepolizumab concentrations and baseline characteristics suggested d…
View article: Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes
Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes Open
Diffuse interstitial lung diseases (ILD) include conditions with identifiable causes such as chronic eosinophilic pneumonia (CEP), sarcoidosis (SAR), chronic hypersensitivity pneumonitis (CHP), and connective tissue disease-associated inte…
View article: Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction
Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction Open
View article: Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial
Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial Open
Japan Registry of Clinical Trials (jRCTs031190237).
View article: The relationship between long COVID, labor productivity, and socioeconomic losses in Japan: A cohort study
The relationship between long COVID, labor productivity, and socioeconomic losses in Japan: A cohort study Open
The study's results revealed a notable decline in labor productivity over time, underscoring the importance of early detection and intervention to mitigate the socio-economic repercussions of long COVID, in addition to its health implicati…
View article: Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment
Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment Open
These findings suggest a suppression of both type 2 and non-type 2 inflammation in response to benralizumab treatment, with potential implications for asthma management. However, the limitations of the study include a small sample size and…
View article: Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period
Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period Open
In this retrospective study the GETE after 2 years of omalizumab therapy emerged as the most meaningful predictor of the long-term effectiveness of omalizumab treatment in patients with severe asthma, highlighting the benefits of prolonged…
View article: Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells
Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells Open
Steroid-resistant asthma is a common cause of refractory asthma. Type 2 inflammation is the main inflammatory response in asthma, and the mechanism underlying the steroid-resistance of type 2 inflammation has not been completely elucidated…
View article: Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients
Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients Open
The analysis of skin surface lipid-RNAs (SSL-RNAs) provides a non-invasive method for understanding the molecular pathology of atopic dermatitis (AD), but its relevance to asthma remains uncertain. Although dupilumab, a biologic drug appro…
View article: Differences between oscillometry measurements obtained by MostGraph-01 and MasterScreen-IOS in patients with asthma
Differences between oscillometry measurements obtained by MostGraph-01 and MasterScreen-IOS in patients with asthma Open
Background Oscillometry devices (also termed forced oscillation technique) devices such as MasterScreen-IOS ® (Jaeger, Hochberg, Germany) and MostGraph-01 ® (Chest, Tokyo, Japan) are useful for obtaining physiological assessments in patien…
View article: Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma
Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma Open
This study has limitations, including its single-arm observational design and the small sample size. However, BT led to a symptomatic improvement in patients with severe asthma. The validated "√WA at Pi10" metric on CT effectively evaluate…
View article: Asthma is a risk factor for general fatigue of long COVID in Japanese nation-wide cohort study
Asthma is a risk factor for general fatigue of long COVID in Japanese nation-wide cohort study Open
In a Japanese population with long COVID, prolonged general fatigue was closely linked to asthma. A preventive approach against COVID-19 is necessary to avoid sustained fatigue and minimize social and economic losses in patients with asthm…
View article: MAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model
MAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model Open
The mitogen-activated protein kinase (MAPK) signaling pathway is involved in the epithelial–mesenchymal transition (EMT) and asthma; however, the role of mitogen-activated protein kinase kinase kinase 19 (MAP3K19) remains uncertain. Theref…
View article: Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics
Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics Open
This study shows that circulating CD69-positive MAIT cells, neutrophils, and serum periostin might predict the real-world response after 1-year mepolizumab treatment. Furthermore, MAIT cells potentially have a protective role against type …
View article: Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma
Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma Open
Benralizumab treatment reduces exacerbations and improves symptom control and quality of life in patients with severe eosinophilic asthma. However, the determination of biomarkers that predict therapeutic effectiveness is required for prec…
View article: Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force Open
Background We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. Methods We used…
View article: DOCK2 is involved in the host genetics and biology of severe COVID-19
DOCK2 is involved in the host genetics and biology of severe COVID-19 Open
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during …
View article: Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen
Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen Open
Allergen immunotherapy is a promising treatment for allergic diseases that induce immune tolerance through the administration of specific allergens. In this study, we investigate the efficacy of sublingual immunotherapy (SLIT) in asthmatic…
View article: P9‐13: Steroid‐resistant airway inflammation in mice induced by chitin
P9‐13: Steroid‐resistant airway inflammation in mice induced by chitin Open
View article: P9‐18: Effects of one‐year of dupilumab treatment in patients with severe asthma
P9‐18: Effects of one‐year of dupilumab treatment in patients with severe asthma Open
growth in FEV 1 and FEF 25-75 and greater decline in FVC when compared with males.Age at baseline, body mass index and inhaled corticosteroid treatment ever also affected patients' lung function growth.
View article: P16‐46: Sarcoid‐like reaction in patients with malignant solid‐tumor: long term clinical course and outcome
P16‐46: Sarcoid‐like reaction in patients with malignant solid‐tumor: long term clinical course and outcome Open
Background: Interstitial lung diseases (ILDs) consist with heterogeneous group of lung disorders with significant morbidity and mortality.Recent clinical trials and prospective cohort studies described the demographic and prognosis of repr…
View article: P9‐15: Examination of the inflammatory pattern of the bronchi in asthma patients with cold airway hyperresponsiveness with controller antiinflammatory therapy
P9‐15: Examination of the inflammatory pattern of the bronchi in asthma patients with cold airway hyperresponsiveness with controller antiinflammatory therapy Open
Background and Aims: Chitin is the second most abundant polysaccharide on earth and acts as a PAMP.Previously we reported chitin induced airway inflammation in a mouse model.In this study, we investigated whether inhaled chitin particles i…
View article: Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan
Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan Open
To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (G…
View article: Clinical and Immunological Effect of Mepolizumab Treatment in Patients with Severe Asthma
Clinical and Immunological Effect of Mepolizumab Treatment in Patients with Severe Asthma Open
View article: A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction
A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction Open
View article: Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice
Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice Open
These results suggest that inhaled chitin induces airway inflammation, AHR, and the production of IL-1β. Furthermore, our findings demonstrate for the first time that inhaled chitin induces steroid-resistant airway inflammation and AHR. In…