2024-10-30
The in vitro cross-reactivity and blood coagulation potential of recombinant porcine factor VIII in Japanese patients with acquired hemophilia A
2024-10-30 • Masahiro Takeyama, Kana Sasai, Yasuo Miyaguchi, Kenichi Ogiwara, Shoko Furukawa, Naruto Shimonishi, Yuto Nakajima, Hitoshi Ueda, Keiji Nogami
Abstract Recombinant porcine factor VIII (rpFVIII) is a hemostatic agent for acquired hemophilia A (AHA). Cross-reaction of auto-antibodies against rpFVIII has been reported, although no data are available in Japanese patients. This study investigated the cross-reactivity and coagulation potential of rpFVIII in plasma samples from Japanese patients with AHA. Cross-reactivity was calculated as the ratio of anti-porcine FVIII inhibitor titer (pFVIII-INH) to human FVIII inhibitor titer. Comprehensive coagulation pote…