Hong‐Jeng Yu
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View article: Diffusion Tensor Imaging along the Perivascular Space and Choroid Plexus Volume in Assessing Brain Glymphatic System in Overt Hypothyroidism
Diffusion Tensor Imaging along the Perivascular Space and Choroid Plexus Volume in Assessing Brain Glymphatic System in Overt Hypothyroidism Open
Background The neurocognitive impairment in overt hypothyroidism (OH) is well-recognized, but its underlying mechanisms remain unclear. The glymphatic system, a recently discovered brain waste-clearance pathway, represents a promising yet …
View article: 160 Rising Incidence of Appendiceal Neoplasms in Appendicitis Cases: A 21-Year Retrospective Analysis from a Single Institution
160 Rising Incidence of Appendiceal Neoplasms in Appendicitis Cases: A 21-Year Retrospective Analysis from a Single Institution Open
Introduction/Objective In the era of cost containment, appendicitis is often managed non-surgically with antibiotics, and when resection occurs, histologic evaluation is typically limited to one or two sections. Primary appendiceal neoplas…
View article: Global, regional, and national burdens of early onset gastric cancer aged 15–49 years from 1990 to 2021 with projections to 2035: a population-based study
Global, regional, and national burdens of early onset gastric cancer aged 15–49 years from 1990 to 2021 with projections to 2035: a population-based study Open
Despite a decrease in ASIR, ASMR, and ASDR globally, the absolute burden of EOGC remains high, with significant regional disparities. Targeted prevention and treatment strategies are needed, particularly in low- and middle-income countries…
View article: Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference
Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference Open
The 2025 CHINAGUT Conference has assembled a panel of 63 experts (30 scientists, 26 physicians, and 7 corporate R&D personnel) collaborated in three groups to present 30 scientific recommendations to advance probiotics, live biotherapeutic…
View article: Implementation of Clinical Services for Adults with Obesity in Different Health Systems: A Scoping Review and Causal Loop Diagram
Implementation of Clinical Services for Adults with Obesity in Different Health Systems: A Scoping Review and Causal Loop Diagram Open
The medical needs of obesity have been underrecognized, though it has posed long-term and enormous challenges to global health. Correspondingly, clinical services for obesity are still uncommon and in their infancy across health systems. I…
View article: Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles
Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles Open
The integrity of sperm chromatin structure was correlated with RSA. Age was identified as a contributing factor to elevated sperm DFI, while occupational environment may also influence semen quality. This study emphasizes the importance of…
View article: Primary Cardiac Angiosarcoma Diagnosed by Multimodality Imaging: A Case Report
Primary Cardiac Angiosarcoma Diagnosed by Multimodality Imaging: A Case Report Open
Background: Primary cardiac tumors are rare. Most primary cardiac tumors are benign, with approximately 10.83% being malignant. We present a rare case of Primary Cardiac Angiosarcoma (PCA) with multiple metastases diagnosed using multimoda…
View article: Editorial Expression of Concern: Alterations in peripheral purinergic and muscarinic signaling of rat bladder after long-term fructose-induced metabolic syndrome
Editorial Expression of Concern: Alterations in peripheral purinergic and muscarinic signaling of rat bladder after long-term fructose-induced metabolic syndrome Open
View article: Associations between maternal exposure to air pollution during pregnancy and trajectories of infant growth: A birth cohort study
Associations between maternal exposure to air pollution during pregnancy and trajectories of infant growth: A birth cohort study Open
Maternal exposure to air pollution during pregnancy was associated with higher risks of impairments in both physical growth, particularly body length, and neurodevelopment.
View article: Characterization of the complete mitochondrial genome of the <i>Hypolimnas misippus</i> Linnaeus 1764 (Lepidoptera: nymphalidae)
Characterization of the complete mitochondrial genome of the <i>Hypolimnas misippus</i> Linnaeus 1764 (Lepidoptera: nymphalidae) Open
In this study, we sequenced the complete mitochondrial genome (mitogenome) of Hypolimnas misippus Linnaeus 1764, which is 15,283 bp in length, containing 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal R…
View article: Retraction Note: Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder
Retraction Note: Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder Open
After publication it was brought to Editors attention that two panels in Figure 5 were previously used in older publications from some of the same authors 1, 2 .The panel 2WBI group, 3-NT in Figure 5 seems very similar to the SP group, CD6…
View article: Lenalidomide or bortezomib as maintenance treatment remedy the inferior impact of high-risk cytogenetic abnormalities in non-transplant patients with newly diagnosed multiple myeloma: a real-world multi-centered study in China
Lenalidomide or bortezomib as maintenance treatment remedy the inferior impact of high-risk cytogenetic abnormalities in non-transplant patients with newly diagnosed multiple myeloma: a real-world multi-centered study in China Open
Maintenance treatment is a pivotal part in the whole process management of multiple myeloma (MM), which further deepens response and improves survival. However, evidence of maintenance in non-transplant MM patients is inadequate in real-wo…
View article: Formation mechanism and research progress of microenvironment before tumor metastasis: a narrative review
Formation mechanism and research progress of microenvironment before tumor metastasis: a narrative review Open
Jingyao Chen, Shuhao Liu, Jianlong Jiang, Zichong Kuo, Jianfeng Li, Chunhong Hong, Hong Yu, Mingzhe Li, Wenhui Wu, Chao Ma
View article: Author response for "High‐Fat Diet‐Induced Metabolic Syndrome Increases Ligature‐Induced Alveolar Bone Loss in Mice"
Author response for "High‐Fat Diet‐Induced Metabolic Syndrome Increases Ligature‐Induced Alveolar Bone Loss in Mice" Open
View article: PCN47 Value of Driver Mutation Testing Strategies based on Next-Generation Sequencing (NGS) for Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC)
PCN47 Value of Driver Mutation Testing Strategies based on Next-Generation Sequencing (NGS) for Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) Open
View article: Double Bridge May Result Similar 5-year Outcome after Heart Transplantation
Double Bridge May Result Similar 5-year Outcome after Heart Transplantation Open
View article: Outcome of Urgent Desensitization in Sensitized Heart Transplant Recipients
Outcome of Urgent Desensitization in Sensitized Heart Transplant Recipients Open
View article: Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis Open
Zhi-Yong Zhang, Ming-Xu Li, Hai Yu, Jun Zhao, Feng-Lin Xiao, Fang Xuan, Yi-Xin Zhao Department of Nephrology, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Ming-Xu LiDepartment of Neph…
View article: Simplified Predictive Nomogram for Postprostatectomy Patients Treated with High-dose Salvage Intensity Modulated Radiation Therapy
Simplified Predictive Nomogram for Postprostatectomy Patients Treated with High-dose Salvage Intensity Modulated Radiation Therapy Open
Background: The role of salvage radiotherapy (RT) is established in prostate cancer patients undergoing radical prostatectomy (RP) with biochemical failure (BCF). Intensity modulated RT (IMRT) is adapted for post-RP treatment. This study a…
View article: Simplified Predictive Nomogram for Postprostatectomy Patients Treated with High-dose Salvage Intensity Modulated Radiation Therapy
Simplified Predictive Nomogram for Postprostatectomy Patients Treated with High-dose Salvage Intensity Modulated Radiation Therapy Open
Purpose:The role of salvage radiotherapy (RT) is established in prostate cancer patients undergoing radical prostatectomy (RP) with biochemical failure (BCF). Intensity modulated RT (IMRT) is adapted for post-RP treatment. This study aimed…
View article: <p>Real-world Data on the Efficacy and Safety of Ixazomib-based Therapy in Multiple Myeloma: A Single-center Study in China</p>
Real-world Data on the Efficacy and Safety of Ixazomib-based Therapy in Multiple Myeloma: A Single-center Study in China Open
The real-world data demonstrated that ixazomib-based therapy was generally effective and safe in the short term for MM patients.
View article: Testosterone regulates the intracellular bacterial community formation of uropathogenic Escherichia coli in prostate cells via STAT3
Testosterone regulates the intracellular bacterial community formation of uropathogenic Escherichia coli in prostate cells via STAT3 Open
View article: Adherence to National Comprehensive Cancer Network Guidelines for BRCA testing among high risk breast Cancer patients: a retrospective chart review study
Adherence to National Comprehensive Cancer Network Guidelines for BRCA testing among high risk breast Cancer patients: a retrospective chart review study Open
View article: CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition
CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition Open
Chunping He, Chao Huang, Rui Zhou, Honggang YuDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, People’s Republic of ChinaObjective: The aberrant expression of circular RNAs (circRNAs)…
View article: Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways
Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways Open
View article: Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells
Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells Open
View article: Correction: Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway
Correction: Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway Open
[This corrects the article DOI: 10.1371/journal.pone.0180244.].
View article: Simplified Predictive Nomogram By High-Dose Salvage Intensity Modulated Radiation Therapy after Radical Prostatectomy for Prostate Cancer
Simplified Predictive Nomogram By High-Dose Salvage Intensity Modulated Radiation Therapy after Radical Prostatectomy for Prostate Cancer Open
View article: CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression
CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression Open
Epithelial-mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm for explaining metastatic behavior during cancer progression. NOV/CCN3 is a matrix-associated protein involved in many cellular functions.…
View article: Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway
Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway Open
Prostatitis is a common condition in adult men of all ages. Uropathogenic Escherichia coli (UPEC) are most frequent pathogen involved in bacterial prostatitis by refluxing the infected urine into prostatic ducts and resulting in an ascendi…