Honglin Chen
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View article: The additive effect of sarcopenia and osteoporosis on all-cause mortality: a cohort analysis in a U.S. population
The additive effect of sarcopenia and osteoporosis on all-cause mortality: a cohort analysis in a U.S. population Open
Objectives The rising incidence of sarcopenia and osteoporosis, conditions closely linked to natural aging and frequently occurring together, may have varying impacts on prognosis. The purpose of this research is to use the NHANES database…
View article: Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13
Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13 Open
Three critically ill or fatal avian influenza A(H5N1) human infections have been reported in North America since November 2024. Notably, all were infected with genotype D1.1 instead of B3.13, the dominant genotype before November 2024. Her…
View article: CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity
CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity Open
The adiponectin (ADPN) receptor (AdipoR) modulates T-cell responses, but its effects remain controversial since signaling can either promote or inhibit T-cell function. Interaction with the ligand ADPN inhibits T-cell responses, but given …
View article: Epstein‐Barr Virus Expressed Long Non‐Coding RNA ( <i>lncBART</i> s) Regulate EBV Latent Genome Replication
Epstein‐Barr Virus Expressed Long Non‐Coding RNA ( <i>lncBART</i> s) Regulate EBV Latent Genome Replication Open
Epstein‐Barr virus (EBV) is a ubiquitous human virus that is also linked to various human cancers. In EBV‐associated nasopharyngeal carcinoma and gastric carcinoma cells, EBV expresses only essential viral antigens but high levels of long …
View article: Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids
Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids Open
H9N2 is currently the second most common avian influenza A virus subtype infecting humans. Monitoring viral phenotypic and genotypic adaptation to humans is crucial for risk assessment. Here, we compared the replication of an H9N2 human is…
View article: Influenza NS1 drives N <sup>6</sup> -methyladenosine (m <sup>6</sup> A)-mediated autoregulation of viral mRNA splicing
Influenza NS1 drives N <sup>6</sup> -methyladenosine (m <sup>6</sup> A)-mediated autoregulation of viral mRNA splicing Open
Influenza A virus replication requires precise balance between unspliced and spliced viral mRNAs. However, the regulatory mechanisms governing viral mRNA splicing remain poorly understood. In this study, we uncover an epigenetic strategy w…
View article: The global state, trajectory and trends of bacterial extracellular vesicles: a bibliometric and visualized analysis
The global state, trajectory and trends of bacterial extracellular vesicles: a bibliometric and visualized analysis Open
Introduction Bacterial extracellular vesicles (BEVs) are nanoscale biological vesicles secreted by bacteria that carry unique cargo and membrane structures derived from their parental bacteria. In recent years, BEVs have been shown to sign…
View article: Argonaute 2 inhibits RIG-I signaling via competition for viral RNA binding
Argonaute 2 inhibits RIG-I signaling via competition for viral RNA binding Open
Interferon (IFN)-dependent responses constitute a critical initial defense against viruses in mammalian cells, while RNA interference (RNAi) acts as an additional strategy to combat invading viral pathogens. Investigating the functionality…
View article: Predictors of diplopia following orbital fractures based on anatomical location, a retrospective cohort study
Predictors of diplopia following orbital fractures based on anatomical location, a retrospective cohort study Open
Among the three anatomical views, fractures in the S2, S3, and A1 regions were significantly associated with preoperative diplopia. For patients with multiple fractures, combined S2 and S3 fractures was linked to a higher probability of di…
View article: The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation
The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation Open
Programmed cell death is a pivotal mechanism of cell‐autonomous immune defense against viral infections. Recent studies indicate that both blocking and promoting cell death negatively affect coronavirus replication, implying that coronavir…
View article: Percutaneous endoscopy in the management of intra-abdominal complex disorders
Percutaneous endoscopy in the management of intra-abdominal complex disorders Open
Background and aims Intra-abdominal complex disorders pose significant challenges to clinicians due to their intricate nature and diagnostic uncertainties. This study aims to comprehensively evaluate the feasibility, safety, and efficacy o…
View article: Recent Progress on the Research of 3D Printing in Aqueous Zinc-Ion Batteries
Recent Progress on the Research of 3D Printing in Aqueous Zinc-Ion Batteries Open
The global transition towards a low-carbon energy system urgently demands efficient and safe energy storage solutions. Aqueous zinc-ion batteries (AZIBs) are considered a promising alternative to lithium-ion batteries due to their inherent…
View article: Evaluating the influence of polystyrene standards on quantification in environmental samples
Evaluating the influence of polystyrene standards on quantification in environmental samples Open
Mismanagement of plastic waste has become an emerging concern as large plastic items fragment into microplastics and nanoplastics (MNPs) in the environment, which, in turn pose potential environmental and human health risks. Pyrolysis-gas …
View article: Large Yellow Croaker (Pseudosciaena crocea, Richardson) E2F4, a Cyclin-Dependent Transcription Factor, Forms a Heterodimer with DP1
Large Yellow Croaker (Pseudosciaena crocea, Richardson) E2F4, a Cyclin-Dependent Transcription Factor, Forms a Heterodimer with DP1 Open
E2F transcription factors regulate cell cycle progression by influencing the expression of proteins required for the G1-S phase transition and DNA synthesis with its heterodimeric partners (DP1 or DP2). The dimerization domain is the E2Fs …
View article: Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data
Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data Open
The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) clade 2.3.4.4b (2024 cattle H5N1…
View article: Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice
Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice Open
Background The origin of intervertebral disc degeneration (IDD) is highly complex, where both cartilage endplate remodeling and vertebral osteoporosis are of utmost importance. Myristic acid (MA), a saturated fatty acid derived from nutmeg…
View article: Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models
Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models Open
The highly pathogenic avian influenza (HPAI) H5N1 virus has been endemic in aquatic birds since 1997, causing outbreaks in domestic poultry and occasional human infections worldwide. Recently, the cross-species transmission of a new reasso…
View article: Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice
Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice Open
The newly emerged avian influenza A H5N1 Clade 2.3.4.4b can infect dairy cows and shed live virus in their milk. Sporadic cattle-to-human infections have been reported, highlighting the urgent need to understand its pathogenesis in mammals…
View article: A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs
A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs Open
Influenza A virus transcribes viral mRNAs from the eight segmented viral genome when it infects. The kinetics of viral transcription, nuclear export of viral transcripts, and their potential variation between the eight segments are poorly …
View article: Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b
Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b Open
Oncogenic gene fusions are key drivers of cancer, yet most remain untargetable by current therapies. Here, we establish CRISPR- Psp Cas13b as a personalizable platform for systematic silencing of various fusion transcripts. We reveal that …
View article: A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs
A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs Open
Influenza A virus transcribes viral mRNAs from the eight segmented viral genome when it infects. The kinetics of viral transcription, nuclear export of viral transcripts, and their potential variation between the eight segments are poorly …