Explanipedia

Treatment Duration in Bacterial Prosthetic Joint Infections: A Narrative Review of Current Evidence Open

Hajer Harrabi, Christel Mamona-Kilu, Ellie G Meyer, Emma d’Anglejan Chatillon, Nathalie Dournon , et al. · 2025

Background/Objectives: The optimal duration of antibiotic therapy for bacterial prosthetic joint infections (PJI) remains a topic of considerable debate. Current recommendations are often based on limited evidence and expert consensus. Eme…

Management of latent TB infection: a national survey of French physicians Open

Nathalie Dournon, Yacine Tandjaoui-Lambiotte, Christel Mamona Kilu, Phuong Thu Phan, P Fraisse , et al. · 2025

International audience

Artificial intelligence and infectious diseases: Scope and perspectives Open

Salam Abbara, Yoann Crabol, Jeanne Goupil de Bouillé, Aurélien Dinh, David Morquin · 2025

Artificial intelligence (AI) is set to permeate every facet of infectious disease practice-from prevention and public health surveillance to epidemic management and bedside care. Routine care data (laboratory results, medication orders, pr…

Lung ultrasonography for community-acquired pneumonia diagnosis Open

Damien Basille, Yacine Tandjaoui-Lambiotte, M Blot, Pierre Fillâtre, Aurélien Dinh , et al. · 2025

Over the past two decades, several studies have assessed the performance of lung ultrasonography in the diagnosis of community-acquired pneumonia (CAP). The performance of this diagnostic tool, when used by clinicians other than radiologis…

Value of molecular biology tests in community-acquired acute pneumonia Open

Vincent Cattoir, Aurélien Dinh, Sophie Jarraud, Alban Le Monnier, Paul Loubet · 2025

For patients hospitalized with community-acquired acute pneumonia (CAP), molecular tools (especially multiplex PCR syndromic panels) are associated with a significant improvement of microbiological diagnosis yield, compared with convention…

Indications for corticosteroids in the treatment of Community-Acquired pneumonia Open

Mathieu Blot, Damien Basille, Aurélien Dinh, François Barbier, Pierre Fillâtre · 2025

Preceding guidelines on treatment and management of community-acquired pneumonia (CAP) do not endorse systematic use of corticosteroids. The data in the literature show contradictory results; while some have suggested clinical improvement …

Antibiotic combination indications for the treatment of community-acquired acute pneumonia Open

Pierre Fillâtre, Mathieu Blot, Damien Basille, Yacine Tandjaoui-Lambiotte, François Barbier , et al. · 2025

Empirical dual combination therapy with beta-lactam and macrolide is often the standard treatment of community-acquired acute pneumonia (CAP) in adults hospitalized in non-intensive care units. However, several recent studies question this…

Duration of antibiotic treatment for community-acquired pneumonia Open

Aurélien Dinh, David Lebeaux · 2025

Previous guidelines have recommended 5-day antibiotic treatment for community-acquired pneumonia (CAP) patients manifesting clinical improvement after 48-72 h, and seven-day treatment for other, uncomplicated forms of CAP. Three meta-analy…

A dedicated skin-to-brain circuit for cool sensation in mice Open

Han Kyu Lee, Chia Chun Hor, Lorraine Horwitz, Ailin E. Xiong, Xinyu Su , et al. · 2025

Cutaneous infections with Corynebacterium diphtheriae in France: A cohort study Open

Héloise Mazoyer, Emma D’Anglejan, Nancy P. Blumenthal, Ahmed Younes, Anne‐Laure Roux , et al. · 2025

Physicians should remain vigilant for cutaneous diphtheria in travelers and immunocompromised patients. However, accurate diagnosis can be challenging due to the presence of polymicrobial infections and common co-pathogens. Actual incidenc…

Prosthetic Joint Infections: A Systematic Review Open

Hajer Harrabi, Christel Mamona Kilu, Ellie G Meyer, Emma d'Anglejan Chatillon, Nathalie Dournon , et al. · 2025

Background/Objectives: The optimal duration of antibiotic therapy, a cornerstone of PJI treatment, remains a topic of considerable debate, with current recommendations often based on limited evidence and expert consensus. Emerging evidence…

Navigating treatment duration in osteoarticular Candida infections Open

Aurélien Dinh, Étienne Canouï, Brad Spellberg · 2025

Management of pressure injuries with associated osteomyelitis in people with spinal cord injury: a national survey of referral centers in France Open

H. Le Liepvre, Emma D’Anglejan, H. Chaussard, Damien Marmouset, K. Allepot , et al. · 2025

Suppressive Antibiotic Therapy in Prosthetic Joint Infections: A Contemporary Overview Open

Hajer Harrabi, Ellie G Meyer, Nathalie Dournon, Frédérique Bouchand, Christel Mamona Kilu , et al. · 2025

The management of prosthetic joint infections (PJIs) poses significant challenges, requiring a multidisciplinary approach involving surgical, microbiological, and pharmacological expertise. Suppressive antibiotic therapy (SAT) has emerged …

Update of guidelines for management of Community Acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF) Open

Aurélien Dinh, François Barbier, Jean‐Pierre Bédos, Mathieu Blot, Vincent Cattoir , et al. · 2025

Suppressive Antibiotic Therapy in Prosthetic Joint Infections: A Contemporary Overview Open

Hejer Harrabi, Ellie G Meyer, Nathalie Dournon, Frédérique Bouchand, Christel Mamona , et al. · 2025

The management of prosthetic joint infections (PJIs) poses significant challenges, requiring a multidisciplinary approach involving surgical, microbiological, and pharmacological expertise. Suppressive antibiotic therapy (SAT) has emerged …

Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice Open

Sandra J. Poulson, Aleksandrina Skvortsova, Lisiê Valéria Paz, Wanning Cui, Antonietta Mandatori , et al. · 2025

The nocebo effect, the evil twin of the better-known placebo effect in which anticipation of harm causes that harm, is increasingly thought to be responsible for poor clinical outcomes. In humans, nocebo hyperalgesia (i.e., increased sensi…

Correction: Pregnant women with mild COVID-19 followed in community setting by telemedicine, and factors associated with unfavorable outcome Open

Aurélien Dinh, Florian Drouet, Agnès Dechartres, Youri Yordanov, Clara Duran , et al. · 2025

[This corrects the article DOI: 10.1371/journal.pone.0288845.].

Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC) Open

Elise Pesonel, Cédric Laouénan, Laetitia Guiraud, Josephine Bourner, Isabelle Hoffmann , et al. · 2025

Background The global mpox outbreak that started in May 2022 was caused by a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV). It differed from the traditional Western and Central Africa disease in transmission pat…

National Cohort of Compassionate Use of Meropenem–Vaborbactam: No Benefit over Meropenem for Pseudomonas aeruginosa Open

Aurélien Dinh, Alexandre Bleibtreu, Clara Duran, Frédérique Bouchand, Alexie Bosch , et al. · 2024

Background: Meropenem–vaborbactam (MEM-VAB) is a novel carbapenem-beta-lactamase-inhibitor combination that demonstrates activity against carbapenem-resistant (CR) Gram-negative bacteria, and more specifically KPC-producers, since vaborbac…

New pedagogical tools for vaccine education: preparing future healthcare workers for the next pandemic Open

Sylvain Gautier, Mia-Marie Hammarlin, Edit Paulik, Ilaria Montagni, Judith E. Mueller , et al. · 2024

Vaccine hesitancy (VH) is an issue for healthcare students, influenced by safety concerns and misinformation. The need for better communication training and understanding sociocultural factors in VH was highlighted in a European University…

Urinary schistosomiasis: The Corsican file Open

Fabien Saint, J.R. Boissier, P Arnaud, Anne Totet, Aurélien Dinh , et al. · 2024

Effectiveness of temocillin in treatment of non-urinary tract infections caused by ESBL-producing Enterobacterales and risk factors for failure Open

Christel Mamona Kilu, Camille Menvielle, Aldo Cataldi, Antoine Hamon, Clara Duran , et al. · 2024

Objectives To describe the real-life use of temocillin for non-urinary tract infections, to assess its effectiveness in infections caused by ESBL-producing Enterobacterales, and to identify risk factors for treatment failure. Method Retros…

Prosthetic Joint Infections due to <i>Candida</i> Species: A Multicenter International Study Open

Aurélien Dinh, Martin McNally, Emma D’Anglejan, Christel Mamona Kilu, J. Lourtet , et al. · 2024

Background Prosthetic joint infection (PJI) caused by Candida spp is a severe complication of arthroplasty. We investigated the outcomes of Candida PJI. Methods This was a retrospective observational multinational study including patients …

Syphilis should not be overlooked in any individual, irrespective of their condition Open

Oriane Cellier, Juliette Jourdan, Lotfi Dahmane, Véronique Perronne, Aurélien Dinh , et al. · 2024

Introduction: Syphilis remains a significant challenge in public health, largely because of its diverse clinical manifestations, often resulting in underdiagnosis especially among patients with neurogenic disability. Case description: We p…

What Place Is There for Long-Acting Antibiotics in the Management of Gram-Positive Infections? A Qualitative Cross-Sectional Study Open

Aurélien Dinh, Guillaume Béraud, Johan Courjon, Yann Le Goff, N. Ettahar , et al. · 2024

Objectives. To identify the current practices with long half-life lipoglycopeptides (LGPs) and potential use/position of oritavancin. Results. Despite their indication being limited to skin and soft tissue infections (SSTIs), long half-lif…

Bacterial diversity and specific taxa are associated with decolonization of carbapenemase-producing enterobacterales after fecal microbiota transplantation Open

Benjamin Davido, Andrea R. Watson, Pierre de Truchis, Gianluca Galazzo, Aurélien Dinh , et al. · 2024

Should we, and how to, optimize cefiderocol administration during severe nosocomial pneumonia due to carbapenem-resistant Acinetobacter baumanii? A viewpoint Open

Julien Massol, Aurélien Dinh, Katy Jeannot, Clara Duran, Frédérique Bouchand , et al. · 2024

Further research is needed to determine the optimal cefiderocol dosage and administration (mono vs. dual therapy, continuous vs. intermittent infusion), in severe Acinetobacter baumannii nosocomial pneumonia.

Prosthetic Joint Infections Caused by Mycobacterium tuberculosis Complex—An ESGIAI–ESGMYC Multicenter, Retrospective Study and Literature Review Open

Álvaro Auñón, Llanos Salar‐Vidal, Ignacio Mahíllo, FABIANA RODRIGUES DE ALMEIDA, Pedro Pereira , et al. · 2024

Purpose: While tuberculosis remains a significant global health concern, prosthetic joint infections (PJIs) caused by members of the Mycobacterium tuberculosis complex are exceptionally rare. Our objective is to perform a retrospective sea…

Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicentre prospective cohort study Open

Léa Poussier, Alexandra Mailles, Pierre Tattevin, J.‐P. Stahl, Pierre Fillâtre , et al. · 2024

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