Van T. Hoang
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View article: NEK Family Kinases: Structure, Function, and Role in Disease
NEK Family Kinases: Structure, Function, and Role in Disease Open
The Never-in-Mitosis A-Related Kinase (NEK) family is an important, yet largely understudied, family of protein kinases involved in the regulation of a variety of critical cellular processes. Consequently, dysregulation of NEK function has…
View article: ĐÁNH GIÁ CHẤT LƯỢNG TIÊU BẢN CẮT LẠNH BẰNG MÁY PRESTOCHILL TẠI BỆNH VIỆN E
ĐÁNH GIÁ CHẤT LƯỢNG TIÊU BẢN CẮT LẠNH BẰNG MÁY PRESTOCHILL TẠI BỆNH VIỆN E Open
Mục tiêu: Đánh giá chất lượng tiêu bản cắt lạnh trên máy PrestoCHILL tại Khoa Giải phẫu bệnh, Bệnh viện E. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 97 mẫu sinh thiết cắt lạnh từ tháng 3–7/2025. Kết quả: Tuổi trung bình bện…
View article: NEK Family Kinases: Structure, Function, and Role in Disease
NEK Family Kinases: Structure, Function, and Role in Disease Open
The Never-in-Mitosis A-Related Kinase (NEK) family is an important, yet largely understudied, family of protein kinases involved in the regulation of a variety of critical cellular processes. Consequently, dysregulation of NEK function has…
View article: Oncogenic effects of ECM remodeling in obesity and breast cancer
Oncogenic effects of ECM remodeling in obesity and breast cancer Open
View article: NUAK kinases: Signaling mechanisms and therapeutic applications
NUAK kinases: Signaling mechanisms and therapeutic applications Open
View article: Adipose Stromal Cell Heterogeneity and Trafficking: Implications for Breast Cancer Metastasis and Obesity
Adipose Stromal Cell Heterogeneity and Trafficking: Implications for Breast Cancer Metastasis and Obesity Open
Adipose-derived stem cells (ASCs) have been extensively investigated for regeneration and tissue engineering applications owing to their inherent regenerative ability. However, the effects of various species and depot-specific extraction s…
View article: Modulation of Estrogen Receptor Activity by the Phytoalexin Tuberosin Produced from Elicited Kudzu (<i>Pueraria lobata</i>)
Modulation of Estrogen Receptor Activity by the Phytoalexin Tuberosin Produced from Elicited Kudzu (<i>Pueraria lobata</i>) Open
Kudzu's invasive nature has contributed to its classification as a weed, as it frequently outcompetes native plant species, leading to extensive overgrowth. Efforts to control kudzu have proven challenging, with moderate success using phys…
View article: Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells
Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells Open
View article: Context-Dependent Estrogenic Actions of (+)-Pisatin Produced in Elicited Green or Snow Pea (<i>Pisum sativum</i>)
Context-Dependent Estrogenic Actions of (+)-Pisatin Produced in Elicited Green or Snow Pea (<i>Pisum sativum</i>) Open
Legumes are a predominant source of isoflavones, termed phytoestrogens, that mimic 17β-estradiol (E2). Phytoalexins are inducible isoflavones produced in plants subjected to environmental stressors (e.g., UV, heat, or fungi). This study in…
View article: Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer
Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is a highly invasive breast cancer subtype that is challenging to treat due to inherent heterogeneity and absence of estrogen, progesterone, and human epidermal growth factor 2 receptors. Kinase signali…
View article: ĐỐI CHIẾU TỶ LỆ BỘC LỘ DẤU ẤN VIMENTIN VỚI ĐỘ MÔ HỌC, TYP MÔ HỌC, GIAI ĐOẠN BỆNH SAU PHẪU THUẬT CỦA UNG THƯ BIỂU MÔ TUYẾN DẠ DÀY TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI NĂM 2022-2023
ĐỐI CHIẾU TỶ LỆ BỘC LỘ DẤU ẤN VIMENTIN VỚI ĐỘ MÔ HỌC, TYP MÔ HỌC, GIAI ĐOẠN BỆNH SAU PHẪU THUẬT CỦA UNG THƯ BIỂU MÔ TUYẾN DẠ DÀY TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI NĂM 2022-2023 Open
Mục tiêu: Đối chiếu tỷ lệ bộc lộ dấu ấn Vimentin với độ mô học, typ mô học, giai đoạn bệnh sau phẫu thuật của ung thư biểu mô tuyến dạ dày tại Bệnh viện Đại học Y Hà Nội năm 2022-2023. Đối tượng và phương pháp nghiên cứu: mô tả cắt ngang, …
View article: Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer
Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer Open
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. A defining feature of TNBC is the propensity to metastasize and acquire resistance to cytotoxic agents. Mitogen activ…
View article: NEK5 Activity Regulates the Mesenchymal and Migratory Phenotype in Breast Cancer Cells
NEK5 Activity Regulates the Mesenchymal and Migratory Phenotype in Breast Cancer Cells Open
Purpose: Breast cancer remains a prominent global disease affecting women worldwide despite the emergence of novel therapeutic regimens. Metastasis is responsible for most cancer-related deaths, and acquisition of a mesenchymal and migrato…
View article: Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant‑resistant phenotype in breast cancer cells
Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant‑resistant phenotype in breast cancer cells Open
Chemokine receptor 4 (CXCR4) and its ligand stromal-derived factor 1 (SDF-1) have well-characterized functions in cancer metastasis; however, the specific mechanisms through which CXCR4 promotes a metastatic and drug-resistant phenotype re…
View article: Immunological properties of the chicken egg yolk (IgY) antibodies against Vietnamese cobra Naja Naja venom
Immunological properties of the chicken egg yolk (IgY) antibodies against Vietnamese cobra Naja Naja venom Open
Venomous snake bite is common poisonous accident and important medical problem around the world. The snake anti-venom is only type-specific protection to each venom type that was used to immunize. In this study, the chicken egg yolk (IgY) …
View article: A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways Open
Breast cancer affects women globally; the majority of breast cancer-related mortalities are due to metastasis. Acquisition of a mesenchymal phenotype has been implicated in the progression of breast cancer cells to an invasive, metastatic …
View article: ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer
ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer Open
Conventional mitogen-activated protein kinase (MAPK) family members regulate diverse cellular processes involved in tumor initiation and progression, yet the role of ERK5 in cancer biology is not fully understood. Triple-negative breast ca…
View article: The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells Open
View article: Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer
Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer Open
Epithelial to mesenchymal transition (EMT) is a cellular program that converts non-motile epithelial cells into invasive mesenchymal cells. EMT is implicated in cancer metastasis, chemo-resistance, cancer progression, and generation of can…
View article: Abstract 1879: Novel diphenylamine analogs induce mesenchymal to epithelial transition and enhance the sensitivity of breast cancer cells to conventional chemotherapeutic agents
Abstract 1879: Novel diphenylamine analogs induce mesenchymal to epithelial transition and enhance the sensitivity of breast cancer cells to conventional chemotherapeutic agents Open
Epithelial to mesenchymal transition is an important cellular adaptation that helps cancer cells acquire a spindle-like phenotype from a cuboidal phenotype, degrade the extracellular matrix, invade the neighboring tissues, and metastasize …
View article: Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model Open
View article: Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model
Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model Open
Claudin-low triple negative breast cancer (CL-TNBC) is a clinically aggressive molecular TNBC subtype characterized by a propensity to metastasize, recur and acquire chemoresistance. CL-TNBC has a diverse intra- and extracellular compositi…
View article: Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes Open
Triple negative breast cancers (TNBCs) have high recurrence and metastasis rates. Acquisition of a mesenchymal morphology and phenotype in addition to driving migration is a consequential process that promotes metastasis. Although some kin…
View article: Oncogenic signaling of MEK5-ERK5
Oncogenic signaling of MEK5-ERK5 Open
View article: Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation
Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation Open
Estrogen receptor alpha (ERα) signaling pathways are frequently disrupted in breast cancer and contribute to disease progression. ERα signaling is multifaceted and many ERα regulators have been identified including transcription factors an…
View article: Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1
Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1 Open
Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11), has been identified as a tumor suppressor in many cancers including breast. Low LKB1 expression has been associated with poor prognosis of breast cancer patients, an…