Khê Hoang‐Xuan
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View article: P14.07.B CAR T-CELL THERAPY IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS: A MULTICENTER RETROSPECTIVE STUDY FROM THE LOC NETWORK
P14.07.B CAR T-CELL THERAPY IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS: A MULTICENTER RETROSPECTIVE STUDY FROM THE LOC NETWORK Open
BACKGROUND The use of CAR T-cell therapy has been delayed in primary central nervous system lymphomas (PCNSL) due to the fear of unacceptable neurotoxicity. However, several recent small series (<30 patients) have shown promising result…
View article: P14.29.B QUANTITATIVE BRAIN MRI ANALYSIS IN NEURODEGENERATIVE LANGERHANS CELL HISTIOCYTOSIS
P14.29.B QUANTITATIVE BRAIN MRI ANALYSIS IN NEURODEGENERATIVE LANGERHANS CELL HISTIOCYTOSIS Open
BACKGROUND Neurodegenerative Langerhans Cell Histiocytosis (ND-LCH) is a severe central nervous system involvement complicating LCH. ND-LCH is characterized by a cerebellar ataxia, pyramidal signs, pseudobulbar palsy, cognitive impairment,…
View article: P14.05.B CAR T-CELL THERAPY DOES NOT LEAD TO MEDIUM-TERM NEUROCOGNITIVE DETERIORATION IN PATIENTS WITH CENTRAL NERVOUS SYSTEM LYMPHOMAS. A LOC NETWORK STUDY
P14.05.B CAR T-CELL THERAPY DOES NOT LEAD TO MEDIUM-TERM NEUROCOGNITIVE DETERIORATION IN PATIENTS WITH CENTRAL NERVOUS SYSTEM LYMPHOMAS. A LOC NETWORK STUDY Open
BACKGROUND Several recent studies have shown promising efficacy of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in central nervous system (CNS) lymphomas. Data regarding neurotoxicity were reassuring, with rates of severe acute…
View article: Automatic Segmentation of Primary Central Nervous System Lymphoma at Clinical Routine Postcontrast T1-weighted MRI
Automatic Segmentation of Primary Central Nervous System Lymphoma at Clinical Routine Postcontrast T1-weighted MRI Open
The trained deep learning model accurately segmented primary central nervous system lymphoma with high generalizability across eight centers, offering an open-source tool that may enhance quantitative imaging evaluation in brain lymphoma.
View article: Tandem combination of <scp>ASCT</scp> and <scp>CAR</scp> T‐cell therapy in highly refractory <scp>CNS</scp> lymphomas
Tandem combination of <span>ASCT</span> and <span>CAR</span> T‐cell therapy in highly refractory <span>CNS</span> lymphomas Open
International audience
View article: IUC24025-78 Early results of moderate hypofractionated radiotherapy implementation for localized prostate cancer patients in Vietnam
IUC24025-78 Early results of moderate hypofractionated radiotherapy implementation for localized prostate cancer patients in Vietnam Open
Background To evaluate the early outcomes of moderately hypofractionated radiotherapy in patients with localized prostate cancer. Methods A prospective, single-institution study was conducted on 41 prostate cancer patients with stage T1-3b…
View article: Preliminary evidence of CAR T‐cell therapy activity in vitreoretinal lymphomas: An LOC network study
Preliminary evidence of CAR T‐cell therapy activity in vitreoretinal lymphomas: An LOC network study Open
View article: Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study
Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study Open
Our analysis revealed that elevated CTI levels were significantly associated with CVD incidence and mortality. CTI may emerge as a unique predictive marker for CVD risk.
View article: The role of immune mechanisms in hypertension and advances in immunomodulatory research
The role of immune mechanisms in hypertension and advances in immunomodulatory research Open
Hypertension is one of the major risk factors for cardiovascular diseases and end-organ damage worldwide. Traditionally, it has been linked to factors such as genetics, diet, and lifestyle. However, increasing research indicates that the i…
View article: Quantitative Brain <scp>MRI</scp> Analysis in Neurodegenerative Langerhans Cell Histiocytosis
Quantitative Brain <span>MRI</span> Analysis in Neurodegenerative Langerhans Cell Histiocytosis Open
Background Neurodegenerative Langerhans Cell Histiocytosis (ND‐LCH) is a severe central nervous system involvement complicating LCH. ND‐LCH is characterized by a cerebellar ataxia, pyramidal signs, pseudobulbar palsy, cognitive impairment,…
View article: 336 | CAR T‐CELL THERAPY IS HIGHLY EFFECTIVE IN VITREORETINAL LYMPHOMAS. A LOC NETWORK STUDY
336 | CAR T‐CELL THERAPY IS HIGHLY EFFECTIVE IN VITREORETINAL LYMPHOMAS. A LOC NETWORK STUDY Open
View article: Elevated TyG index outperforms TyG-BMI in predicting delirium among non-diabetic sepsis patients
Elevated TyG index outperforms TyG-BMI in predicting delirium among non-diabetic sepsis patients Open
Background The Triglyceride Glucose (TyG) index and TyG-Body Mass Index (TyG-BMI), recognized as validated surrogate markers of insulin resistance (IR), have demonstrated prognostic utility in various metabolic disorders. However, their po…
View article: Clinical significance of urine-based automated detection of GSTP1 methylation for the diagnosis of suspected prostate cancer patients
Clinical significance of urine-based automated detection of GSTP1 methylation for the diagnosis of suspected prostate cancer patients Open
Automated detection of urinary GSTP1 methylation significantly enhanced PCa diagnostic value, outperforming PSA in sensitivity, specificity, and accuracy. Combining urinary GSTP1 methylation with PSA notably improved accuracy, especially i…
View article: Comparing foundation models and nnU-Net for segmentation of primary brain lymphoma on clinical routine post-contrast T1-weighted MRI
Comparing foundation models and nnU-Net for segmentation of primary brain lymphoma on clinical routine post-contrast T1-weighted MRI Open
International audience
View article: ICE polychemotherapy is an efficient salvage treatment in primary central nervous system lymphoma: an LOC network study
ICE polychemotherapy is an efficient salvage treatment in primary central nervous system lymphoma: an LOC network study Open
International audience
View article: Unveiling the Clinical and Imaging Signatures of Intravascular Lymphoma of the Central Nervous System: A Multicentric Cohort Study
Unveiling the Clinical and Imaging Signatures of Intravascular Lymphoma of the Central Nervous System: A Multicentric Cohort Study Open
Objective Intravascular lymphoma is a rare subtype of B‐cell lymphoma characterized by a clonal proliferation restricted to the lumen of small vessels. Over 50% of patients exhibit central nervous system (CNS) involvement, but diagnosis is…
View article: High-dose chemotherapy with autologous haematopoietic stem cell transplantation in patients with isolated vitreoretinal lymphoma: a LOC network study
High-dose chemotherapy with autologous haematopoietic stem cell transplantation in patients with isolated vitreoretinal lymphoma: a LOC network study Open
View article: Correction: Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients
Correction: Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients Open
View article: Genetic polymorphism and cluster analyses based on the conserved DNAderived polymorphism markers in the selected Harumanis and non-Harumanismango varieties
Genetic polymorphism and cluster analyses based on the conserved DNAderived polymorphism markers in the selected Harumanis and non-Harumanismango varieties Open
Various mango varieties have been cultivated in Malaysia for decades and the fruit plays a significant impact on trading nationwide. Harumanis is the most outstanding mango variety in terms of taste and quality which led to a premium price…
View article: High-dose chemotherapy with autologous haematopoietic stem cell transplantation in patients with isolated vitreoretinal lymphoma: A LOC network study
High-dose chemotherapy with autologous haematopoietic stem cell transplantation in patients with isolated vitreoretinal lymphoma: A LOC network study Open
Despite its indolent evolution, vitreoretinal lymphoma (VRL) has a poor prognosis due to a major risk of relapse in the central nervous system (CNS) and may necessitate aggressive therapy. However, the use of high-dose chemotherapy with au…
View article: Primary central nervous system lymphomas: EHA–ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Primary central nervous system lymphomas: EHA–ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up Open
View article: Primary central nervous system lymphomas: EHA–ESMO Clinical Practice Guideline for diagnosis, treatment and follow‐up
Primary central nervous system lymphomas: EHA–ESMO Clinical Practice Guideline for diagnosis, treatment and follow‐up Open
Highlights This EHA‐ESMO Clinical Practice Guideline provides key recommendations for managing primary DLBCL of the CNS. The guideline covers clinical, imaging and pathological diagnosis, staging and risk assessment, treatment and follow‐u…
View article: Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review
Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review Open
Background The utility of liquid biopsies is well documented in several extracranial and intracranial (brain/leptomeningeal metastases, gliomas) tumors. Methods The RANO (Response Assessment in Neuro-Oncology) group has set up a multidisci…
View article: CAR T‐cell therapy induces a high rate of prolonged remission in relapsed primary CNS lymphoma: Real‐life results of the LOC network
CAR T‐cell therapy induces a high rate of prolonged remission in relapsed primary CNS lymphoma: Real‐life results of the LOC network Open
The prognosis of relapsed primary central nervous system lymphoma (PCNSL) remains dismal. CAR T‐cells are a major contributor to systemic lymphomas, but their use in PCNSL is limited. From the LOC network database, we retrospectively selec…
View article: Border irregularity loss for automated segmentation of primary brain lymphomas on post-contrast MRI
Border irregularity loss for automated segmentation of primary brain lymphomas on post-contrast MRI Open
International audience
View article: Prognosis of glioblastoma patients improves significantly over time interrogating historical controls
Prognosis of glioblastoma patients improves significantly over time interrogating historical controls Open
View article: Interim FDG-PET improves treatment failure prediction in primary central nervous system lymphoma: An LOC network prospective multicentric study
Interim FDG-PET improves treatment failure prediction in primary central nervous system lymphoma: An LOC network prospective multicentric study Open
Background The purpose of our study was to assess the predictive and prognostic role of 2-18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/MRI during high-dose methotrexate-based chemotherapy (HD-MBC) in de novo primar…
View article: A Delphi study to determine the epidemiology and clinical management of patients treated with HDMTX who develop methotrexate (MTX) delayed elimination in France, Germany, Italy, and the UK
A Delphi study to determine the epidemiology and clinical management of patients treated with HDMTX who develop methotrexate (MTX) delayed elimination in France, Germany, Italy, and the UK Open
Introduction High‐dose methotrexate (HDMTX) is administered for the treatment of some malignancies. Serious complications after the administration of HDMTX are rare, but occasionally MTX may precipitate in the renal tubes causing a delayed…
View article: Artificial intelligence classifies and predicts the outcome of primary CNS and nodal large B-cell lymphomas
Artificial intelligence classifies and predicts the outcome of primary CNS and nodal large B-cell lymphomas Open
Primary Central Nervous System Lymphoma (PCNSL) is a particular extra-nodal subtype of large B-cell lymphoma (LBCL) with dismal prognosis. We propose a novel approach using digital pathology to classify PCNSL, assessing the presence of MYD…
View article: EPCO-52. SUBTYPES AND SURVIVAL ANALYSIS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA WITH RADIOMICS FEATURES
EPCO-52. SUBTYPES AND SURVIVAL ANALYSIS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA WITH RADIOMICS FEATURES Open
Primary Central Nervous System Lymphoma (PCNSL) is a rare and heterogeneous disease with dismal prognosis. Recently, four molecular clusters with clinical relevance have been identified with different potential therapeutic targets in each …