Hobin Lee
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View article: Tracing the global spread of maize (Zea mays L.) through plastome analysis of landraces
Tracing the global spread of maize (Zea mays L.) through plastome analysis of landraces Open
Maize (Zea mays L.) is the most recently domesticated and dispersed worldwide among major cereals. Chloroplast genomes (plastome), with their highly conserved tetrad structure, hold a significant value in phylogenetic research due to their…
View article: Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screening
Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screening Open
USP11 is a promising therapeutic target implicated in Alzheimer's disease and various cancers; however, no specific inhibitors are currently available, with the only known inhibitor being mitoxantrone, which primarily targets topoisomerase…
View article: Discovery of Chemical Scaffolds as Lysophosphatidic Acid Receptor 1 Antagonists: Virtual Screening, <i>In Vitro</i> Validation, and Molecular Dynamics Analysis
Discovery of Chemical Scaffolds as Lysophosphatidic Acid Receptor 1 Antagonists: Virtual Screening, <i>In Vitro</i> Validation, and Molecular Dynamics Analysis Open
Lysophosphatidic acid receptor 1 (LPAR1) is an emerging therapeutic target for numerous human diseases including fibrosis. However, the limited number of available core structures of LPAR1 antagonists has prompted the need for novel chemic…
View article: Cell membrane-derived vesicles for delivery of therapeutic agents
Cell membrane-derived vesicles for delivery of therapeutic agents Open
Cell membranes have recently emerged as a new source of materials for molecular delivery systems. Cell membranes have been extruded or sonicated to make nanoscale vesicles. Unlike synthetic lipid or polymeric nanoparticles, cell membrane-d…
View article: Prohibition of antibiotic growth promoters has affected the genomic profiles of Lactobacillus salivarius inhabiting the swine intestine
Prohibition of antibiotic growth promoters has affected the genomic profiles of Lactobacillus salivarius inhabiting the swine intestine Open
After the introduction of a ban on the use of antibiotic growth promoters (AGPs) for livestock, the feeding environment, including the composition of animal intestinal microbiota, has changed rapidly. We hypothesized that the microbial gen…