Safaa A. Ibrahim
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View article: Hadiths on the Apostate Al-Had and Its Understanding Through the Temporal and Spatial Dimension and Its Application
Hadiths on the Apostate Al-Had and Its Understanding Through the Temporal and Spatial Dimension and Its Application Open
The issue of Al-hudud is considered to be one of the important matters. In this respect many texts in Quran and Sunnah have been provided. The good understanding of these texts is urgently needed in order for its understanding to be rectif…
View article: The rhetorical dimension of the sanctity of the Hijab in ancient Iraqi art
The rhetorical dimension of the sanctity of the Hijab in ancient Iraqi art Open
We all know for certain that the hijab plays a role in preserving the safety of society and its correct growth. Through this study, we tried to explain the concept of the hijab in its legitimate form, as in the first chapter, and openness …
View article: The Relationship between Thyroid Disorders and Prolactin level in the Blood of Perimenopausal Women with Abnormal Uterine Bleeding
The Relationship between Thyroid Disorders and Prolactin level in the Blood of Perimenopausal Women with Abnormal Uterine Bleeding Open
Background: Abnormal uterine bleeding (AUB) is a common perimenopausal problem with numerous explanations and causes, thyroid disorders and hyperprolactinemia are part of these causes. This study aimed to find out the relationship between …
View article: A Critical Review of Chloroquine and Hydroxychloroquine as Potential Adjuvant Agents for Treating People with Cancer
A Critical Review of Chloroquine and Hydroxychloroquine as Potential Adjuvant Agents for Treating People with Cancer Open
Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used to treat malaria and autoimmune diseases for more than 70 years; they also have immunomodulatory and anticancer effects, which are linked to autophagy and autophagy-independent m…
View article: Perinatal Outcomes of Pregnancies with Preterm Premature Rupture of Membranes after 34 Weeks of Gestation
Perinatal Outcomes of Pregnancies with Preterm Premature Rupture of Membranes after 34 Weeks of Gestation Open
Background: Preterm premature rupture of the membranes (PPROM) is an important contributor to perinatal mortality and morbidity.Neonatal complications are related primarily to the gestational age at rupture of membranes. Objective:The aim …
View article: Usefulness of Yolk Sac Diameter and Embryonic Heart Rate as Prognostic Factors of Gestational Outcome in Early Singleton Pregnancies
Usefulness of Yolk Sac Diameter and Embryonic Heart Rate as Prognostic Factors of Gestational Outcome in Early Singleton Pregnancies Open
Background: Within the gestational sac, the yolk sac is the first embryonic structure to be seen.The size, shape, and function of the yolk sacs, as well as the heart rates of the developing embryos, all play a role in the evaluation and pr…
View article: Evaluation of Risk Factors and Treatment of Peri-Partum Anemia
Evaluation of Risk Factors and Treatment of Peri-Partum Anemia Open
Iron deficiency anemia (IDA) in pregnancy, i.e., prepartum anemia, is associated with premature birth, low birth weight, and small for gestational age of the newborn and is furthermore closely associated with the occurrence of anemia after…
View article: <i>In vivo</i> anti‐V‐ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses
<i>In vivo</i> anti‐V‐ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses Open
Tumor acidity is the key metabolic feature promoting cancer progression and is modulated by pH regulators on a cancer cell's surface that pump out excess protons/lactic acid for cancer cell survival. Neutralizing tumor acidity improves the…
View article: Comparative study between L-carnitine versus co-enzyme Q10 as an adjuvant therapy to clomiphene resistant pcos women on improving pregnancy rate and prevention of early pregnancy loss
Comparative study between L-carnitine versus co-enzyme Q10 as an adjuvant therapy to clomiphene resistant pcos women on improving pregnancy rate and prevention of early pregnancy loss Open
Aim of the work:Compare the effectiveness of L-carnitine versus Co-enzyme Q10 on improving pregnancy rates and decraese the rate of early pregnancy loss in patients with PCO resistant to clomiphene citrate.Setting and Design: A prospective…
View article: Prevalence of Hepatitis B and C Virus Infection among Pregnant Women in Sharkia Governorate, Egypt
Prevalence of Hepatitis B and C Virus Infection among Pregnant Women in Sharkia Governorate, Egypt Open
Background and study aim: Viral infections is the cause of liver inflammation, cirrhosis and even liver hepatocellular carcinoma (HCC).Despite the availability of HBV vaccine and antiviral treatment for HBV and HCV both remain a major heal…
View article: Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils
Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils Open
Tumors and neutrophils undergo an unexpected interaction, in which products released by tumor cells interact to support neutrophils that in turn support cancer growth, angiogenesis, and metastasis. A key protein that is highly expressed by…
View article: Does folic acid reduce congenital anomalies and adverse pregnancy outcomes in women received long-term low dose Methotrexate?
Does folic acid reduce congenital anomalies and adverse pregnancy outcomes in women received long-term low dose Methotrexate? Open
Background: Methotrexate (MTX) which is folic acid antagonist is used to treat many diseases, including rheumatic, inflammatory, autoimmune disorders or malignancies; it is also used for the medical treatment of ectopic pregnancy and termi…
View article: Interleukin‐22 promotes development of malignant lesions in a mouse model of spontaneous breast cancer
Interleukin‐22 promotes development of malignant lesions in a mouse model of spontaneous breast cancer Open
Interleukin (IL)‐22 is recognized as a tumor‐supporting cytokine and is implicated in the proliferation of multiple epithelial cancers. In breast cancer, the current knowledge of IL‐22 function is based on cell line models and little is kn…
View article: PREDICTION OF PRETERM DELIVERY IN PREGNANT WOMEN WITH THREATENED PRETERM LABOR USING TRANSVAGINAL ULTRASOUND AND NEUTROPHILS TO LYMPHOCYTES RATIO
PREDICTION OF PRETERM DELIVERY IN PREGNANT WOMEN WITH THREATENED PRETERM LABOR USING TRANSVAGINAL ULTRASOUND AND NEUTROPHILS TO LYMPHOCYTES RATIO Open
Background: Preterm labor is defined as regular contractions of the uterus resulting in changes in the cervix that start before 37 weeks of pregnancy.It contributes directly to estimated one million neonatal deaths annually and is a signif…
View article: Abstract 4600: IL-22 is specifically required for malignancy in breast cancer: A potential target to control cancer metastasis
Abstract 4600: IL-22 is specifically required for malignancy in breast cancer: A potential target to control cancer metastasis Open
IL-22 is important for proliferation and progression of various epithelial cancers. However, in breast cancer, the current knowledge of IL-22 function is based on cell line models and lacks information on stage-specific involvement of IL-2…
View article: Abstract 106: Targeting tumor associated pH regulators: Effective therapeutic strategy in ovarian cancer
Abstract 106: Targeting tumor associated pH regulators: Effective therapeutic strategy in ovarian cancer Open
The cancer cell survival relies on the over-expression of pH regulators that pump out excess protons/lactic acid, in turn acidifying the tumor microenvironment (TME) which further promotes immune suppression and metastasis. Targeting the p…
View article: Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway
Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway Open
Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis-R) display enhanced survival mechanisms to cope with therapeutic stress…
View article: Role of Multidetector Computed Tomography (CT) Virtual Hysteroscopy in the Evaluation of Abnormal Uterine Bleeding in Reproductive Age
Role of Multidetector Computed Tomography (CT) Virtual Hysteroscopy in the Evaluation of Abnormal Uterine Bleeding in Reproductive Age Open
Background. Abnormal uterine bleeding (AUB) may be acute or chronic and is defined as bleeding from the uterine corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the absence of pregnancy. It is a widesprea…
View article: Bifurcation analysis and chaos control of a second-order exponential difference equation
Bifurcation analysis and chaos control of a second-order exponential difference equation Open
The aim of this article is to study the local stability of equilibria, investigation related to the parametric conditions for transcritical bifurcation, period-doubling bifurcation and Neimark-Sacker bifurcation of the following second-ord…
View article: Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells Open
The interaction of recruited immune effector cells and cancer cells within tumor microenvironment (TME) shapes the fate of cancer progression and metastasis. Many cancers including breast cancer, express a specific vacuolar ATPase (a2V) on…
View article: Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells
Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells Open
Breast cancer (BC) Is the most widely recognized threatening malignant disease around the whole world.It Is the second most incessant reason for malignant tumor growth related to death among woman at different ages.Inflammatory Breast Canc…
View article: Safety and Efficacy of Laparoscopic Appendectomy in Pregnant Females
Safety and Efficacy of Laparoscopic Appendectomy in Pregnant Females Open
Introduction: Laparoscopic surgery during pregnancy is contraindicated absolutely or relatively through the last decade; however, laparoscopic appendectomy (LA) is still performed in pregnant women.Materials and methods: Thirty-one pregnan…
View article: Mammary epithelium‐specific inactivation of V‐<scp>ATP</scp>ase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer
Mammary epithelium‐specific inactivation of V‐<span>ATP</span>ase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer Open
Extracellular matrix ( ECM ) critically impacts tumor progression and is influenced by both cancer and host tissue cells. While our understanding of cancer cell ECM remodeling is widespread, the importance of host tissue ECM , which provid…
View article: Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells
Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells Open
In ovarian cancer (OVCA), treatment failure due to chemo-resistance is a serious challenge. It is therefore critical to identify new therapies that are effective against resistant tumors and have reduced side effects. We recently identifie…
View article: Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8
Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8 Open
Neutrophils play significant regulatory roles within the tumor microenvironment by directly promoting tumor progression that leads to poor clinical outcomes. Identifying the tumor associated molecules that regulate neutrophil infiltration …