Explanipedia

Stable self-assembled oral metformin-bridged nanocochleates against hepatocellular carcinoma Open

Mohamed G. El-Melegy, Amal H. El‐Kamel, Radwa A. Mehanna, Ahmed Gaballah, Hoda M. Eltaher · 2024

Despite its established anti-diabetic activity, Metformin hydrochloride (MET) has been repurposed for the management of hepatocellular carcinoma (HCC). Owing to MET high aqueous solubility and poor oral permeability, a novel nanoplatform i…

A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro Open

Sara Wong, Alexander D. Brown, Abigail B. Abrahams, An Nisaa Nurzak, Hoda M. Eltaher , et al. · 2024

Background/Objectives: Peptide-based treatments represent an expanding area and require innovative approaches to enhance bioavailability. Combination with cell-penetrating peptides (CPPs) is an attractive strategy to improve non-invasive d…

Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment Open

Heba A Fayyaz, Magda A. El-Massik, Mohammed Bahey-El-Din, Amany Abdel Bary, Ossama Y. Abdallah , et al. · 2023

Invasive pulmonary aspergillosis (IPA) is the most devastating Aspergillus-related lung disease. Voriconazole (VRZ) is the first-line treatment against IPA. Despite availability in oral and parenteral dosage forms, risks of systemic toxici…

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing Open

Walaa Metwally, Salma E. El-Habashy, Lobna S. El‐Hosseiny, Marwa M. Essawy, Hoda M. Eltaher , et al. · 2023

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic…

3D PRINTING AND CHARACTERIZATION OF POROUS CHITOSAN BASED NANOCOMPOSITE SCAFFOLDS FOR BONE REGENERATION (IN VITRO and IN VIVO STUDY) Open

Doaa Abo Dahab, Seham Hanafy, Hanaa Aly, Hoda M. Eltaher, Mohamed M. Abdul-Monem · 2023

INTRODUCTION:Bone regeneration still is a challenging task for the maxillofacial surgeon.Autografts and allografts were two extensively used procedures for bone repair in the past.Tissue engineering is a promising method for employing biom…

Orally-delivered insulin-peptide nanocomplexes enhance transcytosis from cellular depots and improve diabetic blood glucose control Open

Sahrish Rehmani, C. McLaughlin, Hoda M. Eltaher, R. Charlotte Moffett, Peter R. Flatt , et al. · 2023

Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities Open

Walaa Metwally, Salma E. El-Habashy, Nefertiti El-Nikhely, Hoda E. Mahmoud, Hoda M. Eltaher , et al. · 2023

Biomedical applications of bio-degradable green composites Open

Labiba K. El‐Khordagui, Hoda M. Eltaher, Somiraa S. Said · 2023

Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings Open

Hoda M. Eltaher, Lia A. Blokpoel Ferreras, Aveen R. Jalal, James E. Dixon · 2022

Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells Open

Nessrin Saleh, Hoda E. Mahmoud, Hoda M. Eltaher, Maged Helmy, Labiba K. El‐Khordagui , et al. · 2022

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal Open

Mohamed G. El-Melegy, Hoda M. Eltaher, Ahmed Gaballah, Amal H. El‐Kamel · 2021

3D printed bioinspired scaffolds integrating doxycycline nanoparticles: Customizable implants for in vivo osteoregeneration Open

Salma E. El-Habashy, Amal H. El‐Kamel, Marwa M. Essawy, Elsayeda-Zeinab A. Abdelfattah, Hoda M. Eltaher · 2021

Prodigiosin-functionalized Lactobacillus acidophilus ghost: A bioinspired combination against colorectal cancer cells Open

Nessrin Saleh, Hoda E. Mahmoud, Hoda M. Eltaher, Maged W. Helmy, Labiba K. El‐Khordagui , et al. · 2021

Lactobacillus acidophilus ghosts (LAGs) with the unique safety of a probiotic, inherent tropism for colon cells and multiple bioactivities offer great promise as drug carrier for colon targeting. We report herein on a novel bioinspired dru…

Biomaterial-Based Nanocomposite for Osteogenic Repurposing of Doxycycline Open

Salma E. El-Habashy, Hoda M. Eltaher, Ahmed Gaballah, Radwa A. Mehanna, Amal H. El‐Kamel · 2021

Our findings indicate that repurposing low-dose DX in complementary biomaterial-based nanosystems can offer a prominent osteogenic candidate for bone-regeneration purposes.

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair Open

Omar Hamid, Hoda M. Eltaher, Virginie Sottile, Jing Yang · 2020

Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites Open

Hoda M. Eltaher, Fatima E. Abukunna, Laura Ruiz‐Cantu, Zack Stone, Jing Yang , et al. · 2020

Combating necrosis, by supplying nutrients and removing waste, presents the major challenge for engineering large three-dimensional (3D) tissues. Previous elegant work used 3D printing with carbohydrate glass as a cytocompatible sacrificia…

Vancomycin-functionalized Eudragit-based nanofibers: Tunable drug release and wound healing efficacy Open

Lamiaa M. Abdel-Rahman, Hoda M. Eltaher, Kamilia Abdelraouf, Mohammed Bahey-El-Din, Cherine A. Ismail , et al. · 2020

Biomedical applications of composite resorbable fibers Open

Somiraa S. Said, Hoda M. Eltaher, Labiba K. El‐Khordagui · 2019

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate Open

Hoda M. Eltaher, Jing Yang, Kevin M. Shakesheff, James E. Dixon · 2016

Making the practically impossible “Merely difficult”—Cryogenic <span>FIB</span> lift‐out for “Damage free” soft matter imaging Open

Christopher Parmenter, Michael W. Fay, Cheryl Hartfield, Hoda M. Eltaher · 2016

The preparation of thinned lamellae from bulk samples for transmission electron microscopy (TEM) analysis has been possible in the focussed ion beam scanning electron microscope (FIB‐SEM) for over 20 years via the in situ lift‐out method. …

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