Hojjat Naderi‐Meshkin
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View article: HDAC11-Driven STAT3 Activation Modulates Epigenetic Regulation, Promoting Pro-Inflammatory Cytokine Production and Endothelial Dysfunction in Diabetes
HDAC11-Driven STAT3 Activation Modulates Epigenetic Regulation, Promoting Pro-Inflammatory Cytokine Production and Endothelial Dysfunction in Diabetes Open
Diabetes mellitus is marked by chronic low-grade inflammation, increasing the risk of infections and vascular complications. In this study, we uncover a novel link between bacterial infection and epigenetic regulation in diabetes. We found…
View article: Unveiling impaired vascular function and cellular heterogeneity in diabetic donor-derived vascular organoids
Unveiling impaired vascular function and cellular heterogeneity in diabetic donor-derived vascular organoids Open
Vascular organoids (VOs), derived from induced pluripotent stem cells (iPSCs), hold promise as in vitro disease models and drug screening platforms. However, their ability to faithfully recapitulate human vascular disease and cellular comp…
View article: Endothelial Cell Dysfunction: Onset, Progression, and Consequences
Endothelial Cell Dysfunction: Onset, Progression, and Consequences Open
Endothelial cell dysfunction is a complex process involving various causes, early and late events, and subsequent consequences. This review provides an overview of each aspect and outlines therapeutic interventions targeting these stages. …
View article: Potential Therapy for Multiple Sclerosis (MS): Investigating the effects of 1,25-dihydroxycholecalciferol on T regulatory cells in Patients with MS
Potential Therapy for Multiple Sclerosis (MS): Investigating the effects of 1,25-dihydroxycholecalciferol on T regulatory cells in Patients with MS Open
The active form of 1,25-dihydroxycholecalciferol and mesenchymal stem cells (MSCs) have immunomodulatory effects on the immune system and could be helpful for regenerative therapeutic application in neurodegenerative diseases. The MSCs wer…
View article: Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies
Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies Open
View article: PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia
PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia Open
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic …
View article: The effects of culture-expanded, non-cryopreserved adipose tissue mesenchymal stem cells (AT-MSCs) on neurological and immunological paradigms in females with secondary progressive multiple sclerosis: a phase I/II clinical trial
The effects of culture-expanded, non-cryopreserved adipose tissue mesenchymal stem cells (AT-MSCs) on neurological and immunological paradigms in females with secondary progressive multiple sclerosis: a phase I/II clinical trial Open
Objective Mesenchymal stem cells (MSCs) due to their immunomodulatory, neurogenerative and self-renewal features have achieved fascinating prospects in regenerative medicine. Adipose tissue is an optimal source of MSCs because of the high …
View article: BS62 ‘Cardiac organoids. A model to investigate the effect of diabetes on cardiac development and function’
BS62 ‘Cardiac organoids. A model to investigate the effect of diabetes on cardiac development and function’ Open
Introduction
Diabetes and associated cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs still represent the leading cause of mortality a…
Diabetes and associated cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs still represent the leading cause of mortality a…
View article: BS16 Blood vessel organoids derived from diabetic patients revealed impaired function based on a subpopulation of endothelial cells
BS16 Blood vessel organoids derived from diabetic patients revealed impaired function based on a subpopulation of endothelial cells Open
Introduction
Impaired function of blood vessels can lead to cardiovascular diseases (CVDs), which is a major cause of death worldwide. The presence of both endothelial cells (ECs) and mural cells is central to the proper function of bl…
Impaired function of blood vessels can lead to cardiovascular diseases (CVDs), which is a major cause of death worldwide. The presence of both endothelial cells (ECs) and mural cells is central to the proper function of bl…
View article: MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer
MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer Open
Background Colorectal cancer (CRC) primary tumours are molecularly classified into four consensus molecular subtypes (CMS1–4). Genetically engineered mouse models aim to faithfully mimic the complexity of human cancers and, when appropriat…
View article: Bioactive glass-collagen/poly (glycolic acid) scaffold nanoparticles exhibit improved biological properties and enhance osteogenic lineage differentiation of mesenchymal stem cells
Bioactive glass-collagen/poly (glycolic acid) scaffold nanoparticles exhibit improved biological properties and enhance osteogenic lineage differentiation of mesenchymal stem cells Open
Today’s using tissue engineering and suitable scaffolds have got attention to increase healing of non-union bone fractures. In this study, we aimed to prepare and characterize scaffolds with functional and mechanical properties suitable fo…
View article: RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction
RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction Open
Vascular diseases account for a significant number of deaths worldwide, with cardiovascular diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden has made the need for an effective treatment strategy a glo…
View article: Impaired Function in Diabetic Patient iPSCs-derived Blood Vessel Organoids Stem from a Subpopulation of Vascular Cells
Impaired Function in Diabetic Patient iPSCs-derived Blood Vessel Organoids Stem from a Subpopulation of Vascular Cells Open
The presence of both endothelial cells (ECs) and mural cells are central to the proper function of blood vessels in health and pathological changes in diseases including diabetes. Although iPSCs-derived vascular organoids (VOs) provide an …
View article: MmCMS: Mouse models’ Consensus Molecular Subtypes of colorectal cancer
MmCMS: Mouse models’ Consensus Molecular Subtypes of colorectal cancer Open
BACKGROUND Colorectal cancer (CRC) primary tumours are molecularly classified into four consensus molecular subtypes (CMS1-4). Genetically engineered mouse models aim to faithfully mimic the complexity of human cancers and, when appropriat…
View article: BS4 The RNA-binding protein quaking-7 is a key regulator of diabetic vasculopathy
BS4 The RNA-binding protein quaking-7 is a key regulator of diabetic vasculopathy Open
Extensive research has repeatedly demonstrated the ability of RNA binding proteins (RBPs) to exhibit control over cellular phenotypes as well as have vital roles in health and disease states. In recent years, RBPs have emerged as critical…
View article: Optimizing Lipofectamine LTX Complex and G-418 Concentration for Improvement of Transfection Efficiency in Human Mesenchymal Stem Cells.
Optimizing Lipofectamine LTX Complex and G-418 Concentration for Improvement of Transfection Efficiency in Human Mesenchymal Stem Cells. Open
Conventional cancer therapies, including surgery, radiotherapy, and chemotherapy, are not tumor site-specific and have cytotoxic and harmful side effects for normal cells. Mesenchymal stem cells (MSCs), due to their tumor-tropism migration…
View article: Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway
Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway Open
Diabetic macular edema (DME) remains a leading cause of vision loss worldwide. DME is commonly treated with intravitreal injections of vascular endothelial growth factor (VEGF) neutralising antibodies. Anti-VEGFs are effective but not all …
View article: Endothelial Cells Derived From Patients With Diabetic Macular Edema Recapitulate Clinical Evaluations of Anti-VEGF Responsiveness Through the Neuronal Pentraxin 2 Pathway
Endothelial Cells Derived From Patients With Diabetic Macular Edema Recapitulate Clinical Evaluations of Anti-VEGF Responsiveness Through the Neuronal Pentraxin 2 Pathway Open
Diabetic macular edema (DME) remains a leading cause of vision loss worldwide. DME is commonly treated with intravitreal injections of vascular endothelial growth factor (VEGF)–neutralizing antibodies. VEGF inhibitors (anti-VEGFs) are effe…
View article: Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway
Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway Open
Diabetic macular edema (DME) remains a leading cause of vision loss worldwide. DME is commonly treated with intravitreal injections of vascular endothelial growth factor (VEGF) neutralising antibodies. Anti-VEGFs are effective but not all …
View article: Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass
Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass Open
View article: The effect of adrenocorticotropic hormone on alpha‐2‐macroglobulin in osteoblasts derived from human mesenchymal stem cells
The effect of adrenocorticotropic hormone on alpha‐2‐macroglobulin in osteoblasts derived from human mesenchymal stem cells Open
Nowadays, alpha‐2‐macroglobulin ( A2M) gene has allocated escalating interest among several genes involved in the pathogenesis of avascular necrosis of the femoral head (ANFH). This molecule could interact with several osteogenic‐related p…
View article: T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis
T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis Open
View article: The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer Open
Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-s…
View article: Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis
Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis Open
View article: <i>In vivo</i> effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury.
<i>In vivo</i> effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury. Open
According to the results concluded from the renoprotective effects of MSC in IRI/AKI, MSCs could be considered as promising therapeutic approach for AKI in clinical applications.
View article: Exosomal lncRNAs and cancer: connecting the missing links
Exosomal lncRNAs and cancer: connecting the missing links Open
Motivation Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related …
View article: Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold
Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold Open
View article: Overexpression of Chemokine Receptors on Neural Stem Cells Pretreated with Valproic acid: Towards Improved Homing
Overexpression of Chemokine Receptors on Neural Stem Cells Pretreated with Valproic acid: Towards Improved Homing Open
Neural stem cells (NSCs) have considerable capacity for self-renewing and also ability for generating neurons in the mammalian brain. However, one of the big challenges is the migration and targeted homing of transplanted NSCs into the inj…
View article: Critical Issues in Successful Production of Skin Substitutes for Wound Healing
Critical Issues in Successful Production of Skin Substitutes for Wound Healing Open
Novel findings on fabrication techniques for bioactive materials, discovering further basic knowledge about wound healing process, and availability of stem cells as alternative candidate for differentiated cells have highly encouraged scie…
View article: Augmented migration of mesenchymal stem cells correlates with the subsidiary CXCR4 variant
Augmented migration of mesenchymal stem cells correlates with the subsidiary CXCR4 variant Open
Use of mesenchymal stem cells (MSCs) has been introduced as a promising tool, for structural and functional recovery of damaged tissues/organs. Studies have indicated that interactions between chemokine receptors and their ligands have a c…