Hoki Fung
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View article: Convergent and Divergent Cerebellar Alterations in 22q11.2 Copy Number Variants
Convergent and Divergent Cerebellar Alterations in 22q11.2 Copy Number Variants Open
Background: Individuals with copy number variants (CNVs) at 22q11.2 are at elevated risk for neurodevelopmental and psychiatric disorders, including autism spectrum disorder and intellectual disability. For psychosis, effects diverge, with…
View article: Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion
Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion Open
22q11.2 deletion (22qDel) and duplication (22qDup) carriers have an increased risk of neurodevelopmental disorders and exhibit altered brain structure, including white matter microstructure. However, the underlying cellular architecture an…
View article: 0130 Frontal Sleep Spindles, IQ, and Sleep Dependent Memory Consolidation in 22q11.2 Deletion Carriers
0130 Frontal Sleep Spindles, IQ, and Sleep Dependent Memory Consolidation in 22q11.2 Deletion Carriers Open
Introduction 22q11.2 deletion (22qDel) is a recurrent copy number variant that greatly increases risk for Schizophrenia and is associated with lower IQ. Recent work by our group has shown diminished sleep dependent memory consolidation (SD…
View article: 0308 Associations Between Actigraph-Derived Sleep Measures and Psychosis-Risk Symptoms in 22q11.2 Deletion Syndrome
0308 Associations Between Actigraph-Derived Sleep Measures and Psychosis-Risk Symptoms in 22q11.2 Deletion Syndrome Open
Introduction 22q11.2 Deletion Syndrome (22q11DS) is a recurrent copy number variant with a wide range of impacts on neurodevelopment. Sleep disturbances are common among 22q11DS, a population at greatly elevated risk for psychosis. Prior s…
View article: Childhood sexual abuse and dissociation: Testing the betrayal trauma theory in two Chinese samples
Childhood sexual abuse and dissociation: Testing the betrayal trauma theory in two Chinese samples Open
Introduction Childhood sexual abuse (CSA) is a major public health concern and is closely associated with dissociative symptoms. According to the betrayal trauma theory, dissociation can be interpreted as a response towards betrayal trauma…
View article: Reliability and validity of a symptom management scale in a sample of Chinese treatment seekers
Reliability and validity of a symptom management scale in a sample of Chinese treatment seekers Open
Introduction The Recovery Assessment Scale-Domains and Stages (RAS-DS) is a recently developed measure that builds on the original Recovery Assessment Scale (RAS). Within the RAS-DS, which measures one’s recovery from mental illness, a spe…
View article: Complex post-traumatic stress disorder and dissociation: Co-occurrence and relationships with depressive symptoms and functional impairments
Complex post-traumatic stress disorder and dissociation: Co-occurrence and relationships with depressive symptoms and functional impairments Open
Introduction Although complex post-traumatic stress disorder (CPTSD) is closely associated with dissociative symptoms, and although dissociation is often conceptualized as a response to trauma, less is known about the co-occurrence of diss…
View article: Online trauma psychoeducation for people with depression and comorbid PTSD symptoms: A pilot randomized controlled trial
Online trauma psychoeducation for people with depression and comorbid PTSD symptoms: A pilot randomized controlled trial Open
Introduction Depression is commonly comorbid with post-traumatic stress disorder (PTSD) symptoms. There is a lack of studies evaluating trauma-informed interventions for people with depression and PTSD symptoms. Objectives We examined whet…
View article: The relationship between complex PTSD and dissociation: A longitudinal study
The relationship between complex PTSD and dissociation: A longitudinal study Open
Introduction Complex post-traumatic stress disorder (C-PTSD) is closely associated with dissociative symptoms. Both of which are common responses to trauma and stress. Yet, not all individuals with C-PTSD experience high levels of dissocia…
View article: A Functional Magnetic Resonance Imaging Investigation of Hot and Cool Executive Functions in Reward and Competition
A Functional Magnetic Resonance Imaging Investigation of Hot and Cool Executive Functions in Reward and Competition Open
Social and environmental influences are important for learning. However, the influence of reward and competition during social learning is less understood. The literature suggests that the ventromedial prefrontal cortex is implicated in ho…
View article: An fMRI Investigation of Hot and Cool Executive Functions in Reward and Competition
An fMRI Investigation of Hot and Cool Executive Functions in Reward and Competition Open
Social and environmental influences are important for learning. However, the influence of reward and competition during social learning is less understood. In this study, we used functional magnetic resonance imaging (fMRI) to determine th…
View article: Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis Open
Background 22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with psychosis and other neurodevelopmental disorders. Adolescents at clinical high risk for psychosis (CHR) have subthreshold psychosis symptoms witho…
View article: Adverse childhood experiences and 8-year trajectories of depressive symptoms in community-dwelling older adults: Results from the English Longitudinal Study of Ageing
Adverse childhood experiences and 8-year trajectories of depressive symptoms in community-dwelling older adults: Results from the English Longitudinal Study of Ageing Open
Introduction The negative impact of adverse childhood experiences (ACEs) on mental health has been well documented. While most of the evidence comes from samples of adolescents and young adults, few studies have investigated whether ACEs c…
View article: Is gaming disorder related to psychological trauma? A scoping review
Is gaming disorder related to psychological trauma? A scoping review Open
Introduction Gaming disorder has become a global concern and it could have a variety of health and social consequences. The trauma model has been applied to the understanding of different types of addictions as behavioral addictions can so…
View article: Effects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11.2 copy number variations
Effects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11.2 copy number variations Open
View article: Effects of Gene Dosage and Development on Subcortical Nuclei Volumes in Individuals with 22q11.2 Copy Number Variations
Effects of Gene Dosage and Development on Subcortical Nuclei Volumes in Individuals with 22q11.2 Copy Number Variations Open
The 22q11.2 locus contains genes critical for brain development. Reciprocal Copy Number Variations (CNVs) at this locus impact risk for neurodevelopmental and psychiatric disorders. Both 22q11.2 deletions (22qDel) and duplications (22qDup)…
View article: Adherence to 24h movement recommendations and health indicators in the ABCD study: Cross-sectional and longitudinal associations with cognition, psychosocial health, BMI and brain structure
Adherence to 24h movement recommendations and health indicators in the ABCD study: Cross-sectional and longitudinal associations with cognition, psychosocial health, BMI and brain structure Open
Adherence to 24h movement guidelines of ≥60min of physical activity, ≤2h of screen time, and 9-11h of sleep has been shown to benefit cognition, physical and psychosocial health in children aged 5-13y. However, these findings are largely b…
View article: Results from TRIO030, a pre-surgical tissue-acquisition study to evaluate molecular alterations in human breast cancer tissue following short-term exposure to the androgen receptor antagonist darolutamide
Results from TRIO030, a pre-surgical tissue-acquisition study to evaluate molecular alterations in human breast cancer tissue following short-term exposure to the androgen receptor antagonist darolutamide Open
View article: Changes in cognitive flexibility and hypothesis search across human life history from childhood to adolescence to adulthood
Changes in cognitive flexibility and hypothesis search across human life history from childhood to adolescence to adulthood Open
How was the evolution of our unique biological life history related to distinctive human developments in cognition and culture? We suggest that the extended human childhood and adolescence allows a balance between exploration and exploitat…