Holger Babbe
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View article: Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation Open
The salt-inducible kinases (SIK) 1–3 are key regulators of pro- versus anti-inflammatory cytokine responses during innate immune activation. The lack of highly SIK-family or SIK isoform-selective inhibitors suitable for repeat, oral dosing…