Holger Fleckenstein
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View article: Focusing of X-ray free-electron laser pulses using multilayer Laue lenses
Focusing of X-ray free-electron laser pulses using multilayer Laue lenses Open
Achieving the highest possible intensities of pulses at X-ray free-electron laser (XFEL) facilities entails focusing the X-ray beam to the smallest possible dimensions. Multilayer Laue lenses are volume diffractive optics that hold promise…
View article: Convergent-beam attosecond x-ray crystallography
Convergent-beam attosecond x-ray crystallography Open
Sub-ångström spatial resolution of electron density coupled with sub-femtosecond to few-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some ot…
View article: Convergent-beam attosecond X-ray crystallography
Convergent-beam attosecond X-ray crystallography Open
Sub-angstrom spatial resolution of electron density coupled with sub-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some other ultrafast pertu…
View article: Fast and efficient hard X-ray projection imaging below 10 nm resolution
Fast and efficient hard X-ray projection imaging below 10 nm resolution Open
High-resolution X-ray imaging of noncrystalline objects is often achieved through the approach of scanning coherent diffractive imaging known as ptychography. The imaging resolution is usually limited by the scattering properties of the sa…
View article: X-ray focusing below 3 nm with aberration-corrected multilayer Laue lenses
X-ray focusing below 3 nm with aberration-corrected multilayer Laue lenses Open
Multilayer Laue lenses are volume diffractive optical elements for hard X-rays with the potential to focus beams to sizes as small as 1 nm. This ability is limited by the precision of the manufacturing process, whereby systematic errors th…
View article: Hard X-ray projection imaging below 5 nm resolution
Hard X-ray projection imaging below 5 nm resolution Open
High-resolution X-ray imaging of non-crystalline objects is often achieved through the approach of scanning coherent diffractive imaging known as ptychography. The imaging resolution is usually limited by the scattering properties of the s…
View article: New aerodynamic lens injector for single particle diffractive imaging
New aerodynamic lens injector for single particle diffractive imaging Open
Contains fulltext : 312063.pdf (Publisher’s version ) (Open Access)
View article: Dose-efficient scanning Compton X-ray microscopy
Dose-efficient scanning Compton X-ray microscopy Open
The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure, induced by the necessarily high energy of short-wavelength radiation. Imaging the inelastically scattered X-ra…
View article: Imaging via Correlation of X-Ray Fluorescence Photons
Imaging via Correlation of X-Ray Fluorescence Photons Open
We demonstrate that x-ray fluorescence emission, which cannot maintain a stationary interference pattern, can be used to obtain images of structures by recording photon-photon correlations in the manner of the stellar intensity interferome…
View article: Dose-efficient Scanning Compton X-ray Microscopy
Dose-efficient Scanning Compton X-ray Microscopy Open
The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure, induced by the necessarily high energy of short-wavelength radiation. Imaging the inelastically scattered X-ra…
View article: Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive
Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive Open
Serial crystallography at conventional synchrotron light sources (SSX) offers the possibility to routinely collect data at room temperature using micrometre-sized crystals of biological macromolecules. However, SSX data collection is not y…
View article: Convergent beam X-ray diffraction using multilayer Laue lenses – an exploration following in John's footsteps
Convergent beam X-ray diffraction using multilayer Laue lenses – an exploration following in John's footsteps Open
View article: Precise wavefront characterization of x-ray optical elements using a laboratory source
Precise wavefront characterization of x-ray optical elements using a laboratory source Open
Improvements in x-ray optics critically depend on the measurement of their optical performance. The knowledge of wavefront aberrations, for example, can be used to improve the fabrication of optical elements or to design phase correctors t…
View article: Robust ptychographic X-ray speckle tracking with multilayer Laue lenses
Robust ptychographic X-ray speckle tracking with multilayer Laue lenses Open
In recent years, X-ray speckle tracking techniques have emerged as viable tools for wavefront metrology and sample imaging applications, and have been actively developed for use at synchrotron light sources. Speckle techniques can recover …
View article: Ptychographic X-ray speckle tracking (PXST) scan of the Siemens star test sample
Ptychographic X-ray speckle tracking (PXST) scan of the Siemens star test sample Open
The PXST scan of the Siemens star test sample measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and numerical apertures of 0.014 and…
View article: Ptychographic X-ray speckle tracking (PXST) scan of the nanoporous gold sample
Ptychographic X-ray speckle tracking (PXST) scan of the nanoporous gold sample Open
The PXST scan of a 2.5 micron-thick piece of nanoporous gold measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and numerical apertur…
View article: Ptychographic X-ray spackle tracking (PXST) scan of the biomineralized shell of a marine planktonic diatom
Ptychographic X-ray spackle tracking (PXST) scan of the biomineralized shell of a marine planktonic diatom Open
The PXST scan of the biomineralized shell of a marine planktonic diatom sample measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and…
View article: Ptychographic X-ray speckle tracking (PXST) scan of the nanoporous gold sample
Ptychographic X-ray speckle tracking (PXST) scan of the nanoporous gold sample Open
The PXST scan of a 2.5 micron-thick piece of nanoporous gold measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and numerical apertur…
View article: Ptychographic X-ray spackle tracking (PXST) scan of the biomineralized shell of a marine planktonic diatom
Ptychographic X-ray spackle tracking (PXST) scan of the biomineralized shell of a marine planktonic diatom Open
The PXST scan of the biomineralized shell of a marine planktonic diatom sample measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and…
View article: Ptychographic X-ray speckle tracking (PXST) scan of the Siemens star test sample
Ptychographic X-ray speckle tracking (PXST) scan of the Siemens star test sample Open
The PXST scan of the Siemens star test sample measured at P11 beamtime of the PETRA III synchrotron radiation facility. The beam was focused with a pair of MLLs with focal lengths of 1.25 mm and 1.15 mm and numerical apertures of 0.014 and…
View article: On the use of multilayer Laue lenses with X-ray Free Electron Lasers
On the use of multilayer Laue lenses with X-ray Free Electron Lasers Open
Multilayer Laue lenses were used for the first time to focus x-rays from an X-ray Free Electron Laser (XFEL). In an experiment, which was performed at the European XFEL, we demonstrated focusing to a spot size of a few tens of nanometers. …
View article: On the use of multilayer Laue lenses with X-ray free electron lasers
On the use of multilayer Laue lenses with X-ray free electron lasers Open
We report on the use of multilayer Laue lenses to focus the intense X-ray Free Electron Laser (XFEL) beam at the European XFEL to a spot size of a few tens of nanometers. We present the procedure to align and characterize these lenses and …
View article: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease Open
A large-scale screen to target SARS-CoV-2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is initially expressed as two large polyproteins. Its main protease, M pro , is essential to yield functional viral proteins,…
View article: New aerodynamic lens injector for single particle diffractive imaging
New aerodynamic lens injector for single particle diffractive imaging Open
An aerodynamic lens injector was developed specifically for the needs of single-particle diffractive imaging experiments at free-electron lasers. Its design allows for quick changes of injector geometries and focusing properties in order t…
View article: Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding Open
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading. In a s…
View article: Segmented flow generator for serial crystallography at the European X-ray free electron laser
Segmented flow generator for serial crystallography at the European X-ray free electron laser Open
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal sus…
View article: Ptychographic X-ray speckle tracking with multi-layer Laue lens systems
Ptychographic X-ray speckle tracking with multi-layer Laue lens systems Open
The ever-increasing brightness of synchrotron radiation sources demands improved X-ray optics to utilize their capability for imaging and probing biological cells, nano-devices and functional matter on the nanometre scale with chemical sen…
View article: Time-Resolved XUV Opacity Measurements of Warm Dense Aluminum
Time-Resolved XUV Opacity Measurements of Warm Dense Aluminum Open
The free-free opacity in plasmas is fundamental to our understanding of energy transport in stellar interiors and for inertial confinement fusion research. However, theoretical predictions in the challenging dense plasma regime are conflic…
View article: Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease Open
Here we present the crystal structure of SARS-CoV-2 main protease (M pro ) covalently bound to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of M pro with HEAT (2-(((4-hydroxyphenethyl)amino)methyl)-3,4-dihydronapht…
View article: Author Correction: Coherent diffractive imaging of microtubules using an X-ray laser
Author Correction: Coherent diffractive imaging of microtubules using an X-ray laser Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.