Holger Lill
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View article: Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions
Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions Open
Functional reintegration into lipid environments represents a major challenge for in vitro investigation of integral membrane proteins (IMPs). Here, we report a new approach, termed LMNG Auto-insertion Reintegration (LAiR), for rein…
View article: Cytochrome <scp><i>bd</i>‐I</scp> from <i>Escherichia coli</i> is catalytically active in the absence of the <scp>CydH</scp> subunit
Cytochrome <span><i>bd</i>‐I</span> from <i>Escherichia coli</i> is catalytically active in the absence of the <span>CydH</span> subunit Open
Cytochrome bd ‐I from Escherichia coli is a terminal oxidase in the respiratory chain that plays an important role under stress conditions. Cytochrome bd ‐I was thought to consist of the major subunits CydA and CydB plus the small CydX sub…
View article: Autoinsertion (LAiR): rapid functional reconstitution of integral membrane proteins into lipid bilayers
Autoinsertion (LAiR): rapid functional reconstitution of integral membrane proteins into lipid bilayers Open
Functional investigation of purified integral membrane proteins (IMPs) is hampered by the need to insert these hydrophobic proteins from the detergent-solubilized state into liposomal membranes. Here we report reintegration of IMPs into a …
View article: Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203
Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203 Open
For the design of next-generation tuberculosis chemotherapy, insight into bacterial defence against drugs is required. Currently, targeting respiration has attracted strong attention for combatting drug-resistant mycobacteria. Q203 (telace…
View article: Cardiolipin enhances the enzymatic activity of cytochrome bd and cytochrome bo3 solubilized in dodecyl-maltoside
Cardiolipin enhances the enzymatic activity of cytochrome bd and cytochrome bo3 solubilized in dodecyl-maltoside Open
View article: Rapid diffusion of large TatA complexes detected using single particle tracking microscopy
Rapid diffusion of large TatA complexes detected using single particle tracking microscopy Open
The twin-arginine translocation (Tat) system transports folded proteins across the cytoplasmic membrane of most bacteria and archaea. TatA, which contains a single membrane-spanning helix, is believed to be responsible for the actual trans…
View article: The carboxy-terminal insert in the Q-loop is needed for functionality of Escherichia coli cytochrome bd-I
The carboxy-terminal insert in the Q-loop is needed for functionality of Escherichia coli cytochrome bd-I Open
View article: Ionophoric effects of the antitubercular drug bedaquiline
Ionophoric effects of the antitubercular drug bedaquiline Open
Significance Antibiotics generally target one of five essential cellular functions in bacteria, but many of these targets are now compromised through rapidly spreading antibiotic resistance. Bedaquiline (BDQ), a new FDA-approved antituberc…
View article: The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd
The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd Open
View article: A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection
A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection Open
Cytochrome bd is a component of the oxidative phosphorylation pathway in many Gram-positive and Gram-negative bacteria. Next to its role as a terminal oxidase in the respiratory chain this enzyme plays an important role as a survival facto…
View article: Cytochrome bd as survival factor in mycobacteria
Cytochrome bd as survival factor in mycobacteria Open
View article: MreB-Dependent Organization of the E. coli Cytoplasmic Membrane Controls Membrane Protein Diffusion
MreB-Dependent Organization of the E. coli Cytoplasmic Membrane Controls Membrane Protein Diffusion Open
View article: Synthesis, characterization and biological activity of fluorescently labeled bedaquiline analogues
Synthesis, characterization and biological activity of fluorescently labeled bedaquiline analogues Open
Labeling the tuberculosis drug bedaquiline with a fluorescent alkynyl-BODIPY moiety does not disrupt its antibacterial properties.
View article: https://www.omicsonline.org/open-access/biodegradable-nanocapsules-containing-a-nanobiotechnological-complex-for-the-invitro-suppression-of-a-melanoma-cell-line-b16f10-JNCR-1000102.php?aid=76290
https://www.omicsonline.org/open-access/biodegradable-nanocapsules-containing-a-nanobiotechnological-complex-for-the-invitro-suppression-of-a-melanoma-cell-line-b16f10-JNCR-1000102.php?aid=76290 Open
Objectives: Development of a novel method for loading drugs into spherical mesoporous silicate nanoparticles (MSNs), and further modification for the loaded MSNs to produce smart drug delivery system. Methods: MSNs have been prepared and l…
View article: The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress Open