Holger Neb
YOU?
Author Swipe
View article: Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data
Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data Open
Purpose Sepsis is a leading cause of morbidity and mortality, yet its documentation and coding in administrative health data remain unreliable. Accurate coding is essential for epidemiological surveillance, quality assurance, and reimburse…
View article: Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions
Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions Open
Introduction Critically ill patients suffer from a wide variety of clinical events, most of them leading to pro-inflammatory states such as sepsis or simply as consequence of major surgery. Many of these patients develop forms of acute kid…
View article: Identification of CRTH2 as a New PPARγ-Target Gene in T Cells Suggested CRTH2 Dependent Conversion of Th2 Cells as Therapeutic Concept in COVID-19 Infection
Identification of CRTH2 as a New PPARγ-Target Gene in T Cells Suggested CRTH2 Dependent Conversion of Th2 Cells as Therapeutic Concept in COVID-19 Infection Open
These mechanistic data suggest an involvement of PPARγ in Th2 differentiation and T cell depletion in COVID-19 patients.
View article: Predicting Survival for Veno-Arterial ECMO Using Conditional Inference Trees—A Multicenter Study
Predicting Survival for Veno-Arterial ECMO Using Conditional Inference Trees—A Multicenter Study Open
Background: Despite increasing use and understanding of the process, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy is still associated with considerable mortality. Personalized and quick survival predictions using mac…
View article: Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry
Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry Open
Background Blood transfusions are common medical procedures and every age group requires detailed insights and treatment bundles. The aim of this study was to examine the association of anaemia, co-morbidities, complications, in-hospital m…
View article: Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study Open
Background A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the major complications of critical COVID-19. Immunoglobulin M (IgM)-enriched immunoglobulins seem especially ca…
View article: Plasma RIPK3 And HMGB1 Predict Severe COVID-19 Progression In ICU Patients: A Single-Center Cohort Study
Plasma RIPK3 And HMGB1 Predict Severe COVID-19 Progression In ICU Patients: A Single-Center Cohort Study Open
Background: Severe progression of coronavirus disease 2019 (COVID‑19) causes respiratory failure and critical illness. Recently, these pathologies have been associated with necroptosis, a receptor‑interacting serine/threonine‑protein kinas…
View article: Pre-existing T cell memory as a risk factor for severe COVID-19 in the elderly
Pre-existing T cell memory as a risk factor for severe COVID-19 in the elderly Open
Summary Coronavirus disease 2019 (COVID-19) displays high clinical variability but the parameters that determine disease severity are still unclear. Pre-existing T cell memory has been hypothesized as a protective mechanism but conclusive …
View article: Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience
Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience Open
Critical care treatment of severely affected COVID-19 patients remains extremely challenging. To date, no experimental intervention has shown a significant benefit in this state of disease. Intravenous application of angiotensin II (ATII) …
View article: In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients
In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients Open
Background The potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demonstrated when using i…
View article: Multimodal Patient Blood Management Program Based on a Three-pillar Strategy
Multimodal Patient Blood Management Program Based on a Three-pillar Strategy Open
Objectives: To determine whether a multidisciplinary, multimodal Patient Blood Management (PBM) program for patients undergoing surgery is effective in reducing perioperative complication rate, and thereby is effective in improving clinica…