Holger Schmidt
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View article: Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health
Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health Open
Organoids are three-dimensional tissue cultures intended to replicate in vivo organs such that their function can be analyzed for applications in drug discovery, diagnostics, and research. This requires the ability to assess organoid healt…
View article: Universal Nanopore Sensor for Amplification-Free and Label-Free Detection of Molecular Biomarkers
Universal Nanopore Sensor for Amplification-Free and Label-Free Detection of Molecular Biomarkers Open
Molecular diagnostics of biomarkers derived from tissues and bodily fluids are developing into a cornerstone of medical testing and potentially the foundation of a personalized medicine approach. Therefore, there is a need for universal bi…
View article: Engineering strong magnon–phonon coupling in single CoFe nanomagnets
Engineering strong magnon–phonon coupling in single CoFe nanomagnets Open
Hybrid magnonic systems are promising platforms for quantum technologies, leveraging coherent coupling between magnons and phonons. Here, we demonstrate strong magnon–phonon coupling in CoFe nanomagnets, a material with high magnetostricti…
View article: Multi-mode interference waveguide spectrometer with optimized performance
Multi-mode interference waveguide spectrometer with optimized performance Open
Chip-scale integrated imaging spectrometers show significant potential for high-performance spectral analysis due to advancements in fabrication and computational techniques. Many practical applications, such as astronomy and molecular spe…
View article: Multi-mode interference waveguide chip-scale spectrometer (invited)
Multi-mode interference waveguide chip-scale spectrometer (invited) Open
Spectral analysis of light is one of the oldest and most versatile scientific methods and the basis of countless techniques and instruments. Miniaturized spectrometers have recently seen great advances, but challenges remain before they ar…
View article: Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems
Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems Open
Particle trapping and enrichment into confined volumes can be useful in particle processing and analysis. This review is an evaluation of the methods used to trap and enrich particles into constrained volumes in microfluidic and nanofluidi…
View article: Air Core ARROW Waveguides Fabricated in a Membrane-Covered Trench
Air Core ARROW Waveguides Fabricated in a Membrane-Covered Trench Open
We report the design, fabrication, and characterization of hollow-core anti-resonant reflecting optical waveguides (ARROWs) fabricated in a membrane-covered trench. These structures are built on silicon wafers using standard microfabricati…
View article: Label-free and amplification-free viral RNA quantification from primate biofluids using a trapping-assisted optofluidic nanopore platform
Label-free and amplification-free viral RNA quantification from primate biofluids using a trapping-assisted optofluidic nanopore platform Open
Viral outbreaks can cause widespread disruption, creating the need for diagnostic tools that provide high performance and sample versatility at the point of use with moderate complexity. Current gold standards such as PCR and rapid antigen…
View article: Nano/microfluidic device for high-throughput passive trapping of nanoparticles
Nano/microfluidic device for high-throughput passive trapping of nanoparticles Open
We present a design and a fabrication method for devices designed for rapid collection of nanoparticles in a fluid. The design uses nanofluidic channels as a passive size-based barrier trap to isolate particles near a central point in the …
View article: Dual optofluidic distributed feedback dye lasers for multiplexed biosensing applications
Dual optofluidic distributed feedback dye lasers for multiplexed biosensing applications Open
Integrated optofluidic devices have become subjects of high interest for rapid biosensor devices due to their unique ability to combine the fluidic processing of small volumes of microfluidics with the analysis capabilities of photonic str…
View article: The PROGRESSUS project - Highly efficient and trustworthy electronics, components and systems for the next generation energy supply infrastructure
The PROGRESSUS project - Highly efficient and trustworthy electronics, components and systems for the next generation energy supply infrastructure Open
High-power requirements of ultra-fast charging stations and the uptake of many low-power charging stations give rise to special challenges when designing smart charging infrastructure. In support of Europe's 2030 climate targets, the EU-fu…
View article: Adaptive time modulation technique for multiplexed on-chip particle detection across scales
Adaptive time modulation technique for multiplexed on-chip particle detection across scales Open
Integrated optofluidic biosensors have demonstrated ultrasensitivity down to single particle detection and attomolar target concentrations. However, a wide dynamic range is highly desirable in practice and can usually only be achieved by u…
View article: Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students
Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students Open
Despite many interventions, science education remains highly inequitable throughout the world. Among all life sciences fields, Bioinformatics and Computational Biology suffer from the strongest underrepresentation of racial and gender mino…
View article: Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors
Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors Open
Optofluidic biosensors have become an important medical diagnostic tool because they allow for rapid, high-sensitivity testing of small samples compared to standard lab testing. For these devices, the practicality of use in a medical setti…
View article: Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel Open
We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping …
View article: All-in-One Optofluidic Chip for Molecular Biosensing Assays
All-in-One Optofluidic Chip for Molecular Biosensing Assays Open
Integrated biosensor platforms have become subjects of high interest for consolidated assay preparation and analysis to reduce sample-to-answer response times. By compactly combining as many biosensor processes and functions as possible in…
View article: Optofluidic Particle Manipulation Platform with Nanomembrane
Optofluidic Particle Manipulation Platform with Nanomembrane Open
We demonstrate a method for fabricating and utilizing an optofluidic particle manipulator on a silicon chip that features a 300 nm thick silicon dioxide membrane as part of a microfluidic channel. The fabrication method is based on etching…
View article: FPGA Integrated Optofluidic Biosensor for Real-Time Single Biomarker Analysis
FPGA Integrated Optofluidic Biosensor for Real-Time Single Biomarker Analysis Open
Integrated optofluidic biosensors can fill the need for sensitive, amplification-free, multiplex single molecule detection which is relevant for containing the spread of infectious diseases such as COVID-19. Here, we demonstrate a rapid sa…
View article: First Experimental Results of the Fast Atmospheric Self-coherent Camera Technique on the Santa cruz Extreme Adaptive optics Laboratory Testbed: Demonstration of High Speed Focal Plane Wavefront Control of Residual Atmospheric Speckles
First Experimental Results of the Fast Atmospheric Self-coherent Camera Technique on the Santa cruz Extreme Adaptive optics Laboratory Testbed: Demonstration of High Speed Focal Plane Wavefront Control of Residual Atmospheric Speckles Open
Current and future high contrast imaging instruments aim to detect exoplanets at closer orbital separations, lower masses, and/or older ages than their predecessors, with the eventual goal of directly detecting terrestrial-mass habitable-z…
View article: First Experimental Results of the Fast Atmospheric Self-coherent Camera\n Technique on the Santa cruz Extreme Adaptive optics Laboratory Testbed:\n Demonstration of High Speed Focal Plane Wavefront Control of Residual\n Atmospheric Speckles
First Experimental Results of the Fast Atmospheric Self-coherent Camera\n Technique on the Santa cruz Extreme Adaptive optics Laboratory Testbed:\n Demonstration of High Speed Focal Plane Wavefront Control of Residual\n Atmospheric Speckles Open
Current and future high contrast imaging instruments aim to detect exoplanets\nat closer orbital separations, lower masses, and/or older ages than their\npredecessors, with the eventual goal of directly detecting terrestrial-mass\nhabitabl…
View article: Performance Comparison of Flow-Through Optofluidic Biosensor Designs
Performance Comparison of Flow-Through Optofluidic Biosensor Designs Open
Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), a…
View article: Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip
Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip Open
Nucleic acids and proteins are the two most important target types used in molecular diagnostics. In many instances, simultaneous sensitive and accurate detection of both biomarkers from the same sample would be desirable, but standard det…
View article: Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay
Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay Open
Significance This work introduces an ultrasensitive single protein capture and detection technique based on a bright fluorescent reporter probe that is sensed on a photonic chip with integrated microfluidics. We perform differentiated dete…
View article: Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection
Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection Open
Optofluidic sensors have enabled single molecule sensing using planar, waveguide dependent multi-spot fluorescence excitation. Here, we demonstrate a new approach to single-particle fluorescence sensing using free-space, top-down illuminat…
View article: Optofluidic Flow-Through Biosensor Sensitivity – Model and Experiment
Optofluidic Flow-Through Biosensor Sensitivity – Model and Experiment Open
We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biolo…