Holger Hoffmann
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View article: LABOR DURATION IS DEFINED BY THE TIME OF DAY OF LABOR INDUCTION
LABOR DURATION IS DEFINED BY THE TIME OF DAY OF LABOR INDUCTION Open
BACKGROUND Spontaneous labor and birth peak during the late evening and early morning hours, indicating an endogenous rhythm in labor onset and birth. We hypothesize that the time-of-day of labor induction will define labor duration and th…
View article: Re-assessment of monoclonal antibodies against diclofenac for their application in the analysis of environmental waters
Re-assessment of monoclonal antibodies against diclofenac for their application in the analysis of environmental waters Open
A formerly developed antibody against diclofenac was re-assessed for its application in an indirect competitive ELISA to determine the pharmaceutical in wastewater. A series of matrix influences and cross-reactivities have been investigate…
View article: Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity
Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity Open
During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus clearance capacity of the downstream process has to be demonstrated. The protein A chromatography step typically achieves less than 4 log10 and is…
View article: Climate and soil input data aggregation effects in crop models
Climate and soil input data aggregation effects in crop models Open
This dataset contains interpolated and aggregated soil and climate data of the region of North Rhine-Westphalia (Germany). The data is provided for grids of 1, 10, 25, 50 and 100 km resolutions. These data grids represent spatial aggregati…
View article: Assoziation, Erwartungen und Barrieren eines Exoskeletteinsatzes in kleinen mittelständischen Unternehmen
Assoziation, Erwartungen und Barrieren eines Exoskeletteinsatzes in kleinen mittelständischen Unternehmen Open
Zusammenfassung Hintergrund Arbeitsbedingte Muskel-Skelett-Erkrankungen (MSE) führen in der herstellenden Industrie zu Krankheitstagen und haben erhebliche wirtschaftliche Folgen für die Unternehmen und die Volkswirtschaft. Exoskelette kön…
View article: Assimilation of Sentinel-2 Estimated LAI into a Crop Model: Influence of Timing and Frequency of Acquisitions on Simulation of Water Stress and Biomass Production of Winter Wheat
Assimilation of Sentinel-2 Estimated LAI into a Crop Model: Influence of Timing and Frequency of Acquisitions on Simulation of Water Stress and Biomass Production of Winter Wheat Open
The Sentinel-2 (S2) Toolbox permits for the automated retrieval of leaf area index (LAI). LAI assimilation into crop simulation models could aid to improve the prediction accuracy for biomass at field level. We investigated if the combined…
View article: The uulmMAC Database—A Multimodal Affective Corpus for Affective Computing in Human-Computer Interaction
The uulmMAC Database—A Multimodal Affective Corpus for Affective Computing in Human-Computer Interaction Open
In this paper, we present a multimodal dataset for affective computing research acquired in a human-computer interaction (HCI) setting. An experimental mobile and interactive scenario was designed and implemented based on a gamified generi…
View article: New Approaches for the Assimilation of LAI Measurements into a Crop Model Ensemble to Improve Wheat Biomass Estimations
New Approaches for the Assimilation of LAI Measurements into a Crop Model Ensemble to Improve Wheat Biomass Estimations Open
The assimilation of LAI measurements, repeatedly taken at sub-field level, into dynamic crop simulation models could provide valuable information for precision farming applications. Commonly used updating methods such as the Ensemble Kalma…
View article: How Do Methods Assimilating Sentinel-2-Derived LAI Combined with Two Different Sources of Soil Input Data Affect the Crop Model-Based Estimation of Wheat Biomass at Sub-Field Level?
How Do Methods Assimilating Sentinel-2-Derived LAI Combined with Two Different Sources of Soil Input Data Affect the Crop Model-Based Estimation of Wheat Biomass at Sub-Field Level? Open
The combination of Sentinel-2 derived information about sub-field heterogeneity of crop canopy leaf area index (LAI) and SoilGrids-derived information about local soil properties might help to improve the prediction accuracy of crop simula…
View article: Our Future in the Anthropocene Biosphere: Global sustainability and resilient societies
Our Future in the Anthropocene Biosphere: Global sustainability and resilient societies Open
View article: Familiennachzug zu subsidiär Schutzberechtigten unter besonderer Berücksichtigung des Kindeswohls
Familiennachzug zu subsidiär Schutzberechtigten unter besonderer Berücksichtigung des Kindeswohls Open
View article: Management and spatial resolution effects on yield and water balance at regional scale in crop models
Management and spatial resolution effects on yield and water balance at regional scale in crop models Open
View article: The effectiveness of supported employment programs: Meta-regression analysis of the global secular trend, 1990 - 2015
The effectiveness of supported employment programs: Meta-regression analysis of the global secular trend, 1990 - 2015 Open
Importance: Supported employment programs aim to re-integrate unemployed people with mental illness into the competitive labour market. While it is known that short-term economic developments like the 2008 recession may have negative conse…
View article: Effects of input data aggregation on simulated crop yields in temperate and Mediterranean climates
Effects of input data aggregation on simulated crop yields in temperate and Mediterranean climates Open
View article: Implications of crop model ensemble size and composition for estimates of adaptation effects and agreement of recommendations
Implications of crop model ensemble size and composition for estimates of adaptation effects and agreement of recommendations Open
View article: Supported Employment und die Schweiz
Supported Employment und die Schweiz Open
Introducing “supported employment” (SE) for the vocational reintegration of people with severe mental illness in a free market economy led to a paradigm shift in the USA and in Europe. Even though SE is in Switzerland generally the first …
View article: Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR
Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR Open
Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that en…
View article: Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR
Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR Open
Hepcidin-25 was identified as the main iron regulator in the human body by binding to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompas…
View article: Improved LC-MS/MS method for the quantification of hepcidin-25 in clinical samples
Improved LC-MS/MS method for the quantification of hepcidin-25 in clinical samples Open
View article: The Impact of Sex Differences on Odor Identification and Facial Affect Recognition in Patients with Schizophrenia Spectrum Disorders
The Impact of Sex Differences on Odor Identification and Facial Affect Recognition in Patients with Schizophrenia Spectrum Disorders Open
Background: Social interactive functions such as facial emotion recognition and smell identification have been shown to differ between women and men. However, little is known about how these differences are mirrored in patients with schizo…
View article: Key functional soil types explain data aggregation effects on simulated yield, soil carbon, drainage and nitrogen leaching at a regional scale
Key functional soil types explain data aggregation effects on simulated yield, soil carbon, drainage and nitrogen leaching at a regional scale Open
The effects of aggregating soil data (DAE) by areal majority of soil mapping units was explored for regional simulations with the soil-vegetation model CoupModel for a region in Germany (North Rhine-Westphalia). DAE were analysed for wheat…
View article: Testosterone and Its Influence on Emotion Recognition in Young, Healthy Males
Testosterone and Its Influence on Emotion Recognition in Young, Healthy Males Open
Emotions are an integral part of our everyday lives and our social interactions. An ability to recognize emotions in the faces of others is essential in order to understand these emotional facets of interaction with others. Although Ekman …
View article: Contribution of crop model structure, parameters and climate projections to uncertainty in climate change impact assessments
Contribution of crop model structure, parameters and climate projections to uncertainty in climate change impact assessments Open
Climate change impact assessments are plagued with uncertainties from many sources, such as climate projections or the inadequacies in structure and parameters of the impact model. Previous studies tried to account for the uncertainty from…
View article: Social exclusion of people with severe mental illness in Switzerland: results from the Swiss Health Survey
Social exclusion of people with severe mental illness in Switzerland: results from the Swiss Health Survey Open
Aims. People with severe mental illness (SMI) have a high risk of living socially excluded from the mainstream society. Policy initiatives and health systems aim to improve the social situation of people who suffer from mental health disab…
View article: Classifying multi-model wheat yield impact response surfaces showing sensitivity to temperature and precipitation change
Classifying multi-model wheat yield impact response surfaces showing sensitivity to temperature and precipitation change Open
View article: The implication of input data aggregation on up-scaling soil organic carbon changes
The implication of input data aggregation on up-scaling soil organic carbon changes Open
In up-scaling studies, model input data aggregation is a common method to cope with deficient data availability and limit the computational effort. We analyzed model errors due to soil data aggregation for modeled SOC trends. For a region …
View article: Performance of process-based models for simulation of grain N in crop rotations across Europe
Performance of process-based models for simulation of grain N in crop rotations across Europe Open
The accurate estimation of crop grain nitrogen (N; N in grain yield) is crucial for optimizing agricultural N management, especially in crop rotations. In the present study, 12 process-based models were applied to simulate the grain N of i…
View article: Effects of Sustained Competitive Employment on Psychiatric Hospitalizations and Quality of Life
Effects of Sustained Competitive Employment on Psychiatric Hospitalizations and Quality of Life Open
The rehabilitative and therapeutic dimensions of functional health conditions are interrelated in the long term. The achievement of sustained competitive employment may be a key factor in improving social and psychiatric outcomes for peopl…
View article: Adaptation response surfaces for managing wheat under perturbed climate and CO2 in a Mediterranean environment
Adaptation response surfaces for managing wheat under perturbed climate and CO2 in a Mediterranean environment Open
View article: Hydrodynamic simulations of moonlet induced propellers in Saturn's\n rings: Application to Bleriot
Hydrodynamic simulations of moonlet induced propellers in Saturn's\n rings: Application to Bleriot Open
One of the biggest successes of the Cassini mission is the detection of small\nmoons (moonlets) embedded in Saturn's rings which cause S-shaped density\nstructures in their close vicinity, called propellers (Spahn and Sremcevic\n2000; Tisc…