Holger Taschenberger
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View article: Ca<sup>2+</sup>-phospholipid–dependent regulation of Munc13-1 is essential for post-tetanic potentiation at mossy fiber synapses and supports working memory
Ca<sup>2+</sup>-phospholipid–dependent regulation of Munc13-1 is essential for post-tetanic potentiation at mossy fiber synapses and supports working memory Open
SUMMARY Hippocampal mossy fiber (hMF) to CA3 pyramidal cell synapses are thought to support the formation of working memory through presynaptic short-term facilitation (STF) and post-tetanic potentiation (PTP). However, the molecular mecha…
View article: Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity
Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity Open
Heterogeneity in synaptic strength and short‐term plasticity (STP) was characterized in post‐hearing rat calyx of Held synapses at near‐physiological external [Ca 2+ ] under control conditions and after experimentally induced synaptic pote…
View article: Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion
Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion Open
The presynaptic SNARE-complex regulator complexin (Cplx) enhances the fusogenicity of primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential-evoked transmitter release. Conversely, though, Cplx loss enhances s…
View article: Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons
Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons Open
Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases the initial synaptic strength but also short-term depression during h…
View article: Erythropoietin re-wires cognition-associated transcriptional networks
Erythropoietin re-wires cognition-associated transcriptional networks Open
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we provide transcriptional hippocam…
View article: Physiology of intracellular calcium buffering
Physiology of intracellular calcium buffering Open
Calcium signaling underlies much of physiology. Almost all the Ca 2+ in the cytoplasm is bound to buffers, with typically only ∼1% being freely ionized at resting levels in most cells. Physiological Ca 2+ buffers include small molecules an…
View article: Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons
Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons Open
Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons LTP increases the initial synaptic strength but also short-term depression during hi…
View article: Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin
Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin Open
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO have remained obscure. Here, we provide encyclopedic transcription…
View article: Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion
Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion Open
Neurotransmitter release is a spatially and temporally tightly regulated process, which requires assembly and disassembly of SNARE complexes to enable the exocytosis of transmitter-loaded synaptic vesicles (SVs) at presynaptic active zones…
View article: Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming Open
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release an…
View article: Author response: Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
Author response: Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Synapses contain a limited number of…
View article: De Novo Missense Variants in <scp> <i>SLC32A1</i> </scp> Cause a Developmental and Epileptic Encephalopathy Due to Impaired <scp>GABAergic</scp> Neurotransmission
De Novo Missense Variants in <span> <i>SLC32A1</i> </span> Cause a Developmental and Epileptic Encephalopathy Due to Impaired <span>GABAergic</span> Neurotransmission Open
Objective Rare inherited missense variants in SLC32A1 , the gene that encodes the vesicular gamma‐aminobutyric acid (GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus. We aimed to clarify if d…
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional state modeling, we demonstrate that a kinetic scheme con…
View article: Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA<sub>A</sub>Rs and cytosolic gephyrin aggregation
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA<sub>A</sub>Rs and cytosolic gephyrin aggregation Open
A bstract The function of GABAergic synapses is critically shaped by cell adhesion proteins that recruit GABA A Rs to synapses and mediate transsynaptic signalling, but the synapse-type-specific function of such synaptic adhesion proteins …
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Please consult the uploaded word file 'figure_4_public.docx' for a description.
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Please consult the uploaded word file 'figure_4_public.docx' for a description.
View article: Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming Open
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release an…
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using non-negative tensor factorization (NTF) and conventional state modelling, we demonstrate that a kinetic sc…
View article: De novo missense variants in <i>SLC32A1</i> cause a neurodevelopmental disorder with epilepsy due to impaired GABAergic neurotransmission
De novo missense variants in <i>SLC32A1</i> cause a neurodevelopmental disorder with epilepsy due to impaired GABAergic neurotransmission Open
We describe four patients with a neurodevelopmental disorder and de novo missense variants in SLC32A1, the gene that encodes the vesicular GABA transporter (VGAT). The main phenotype comprises moderate to severe intellectual disability, ea…
View article: Non-negative Matrix Factorization as a Tool to Distinguish Between Synaptic Vesicles in Different Functional States
Non-negative Matrix Factorization as a Tool to Distinguish Between Synaptic Vesicles in Different Functional States Open
Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before being fusion competent. We present an analysis technique, which decomposes the time course of quantal release during repetitive stimulation as a sum o…
View article: Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices Open
Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic membrane-trafficking events has remained challenging, particularly in functionally distinct syna…
View article: Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release
Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release Open
SNARE-mediated synaptic vesicle (SV) fusion is controlled by multiple regulatory proteins that determine neurotransmitter release efficiency. Complexins are essential SNARE regulators whose mode of action is unclear, as available evidence …
View article: IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses Open
Abnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural…
View article: Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder Open
Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses. They mediate the priming step that renders synaptic vesicles fusion-competent, and their genetic elimination causes a complete block of synaptic t…
View article: Dynamics of volume‐averaged intracellular Ca<sup>2+</sup> in a rat CNS nerve terminal during single and repetitive voltage‐clamp depolarizations
Dynamics of volume‐averaged intracellular Ca<sup>2+</sup> in a rat CNS nerve terminal during single and repetitive voltage‐clamp depolarizations Open
Key points The intracellular concentration of free calcium ions ([Ca 2+ ] i ) in a nerve terminal controls both transmitter release and synaptic plasticity. The rapid triggering of transmitter release depends on the local micro‐ or nanodom…