Holger Wigström
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View article: How do NMDA and AMPA receptors share a common regulatory mechanism that underlies the NMDAR-dependent LTP and LTD?
How do NMDA and AMPA receptors share a common regulatory mechanism that underlies the NMDAR-dependent LTP and LTD? Open
NMDA receptor (NMDAR)-dependent AMPA receptor (AMPAR)-mediated synaptic plasticity, encompassing long-term potentiation (LTP) and depression (LTD), is considered a cellular mechanism for learning and memory. However, the intertwined regula…
View article: Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice Open
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced…
View article: Complex Control of Striatal Neurotransmission by Nicotinic Acetylcholine Receptors via Excitatory Inputs onto Medium Spiny Neurons
Complex Control of Striatal Neurotransmission by Nicotinic Acetylcholine Receptors via Excitatory Inputs onto Medium Spiny Neurons Open
The prevalence of nicotine dependence is higher than that for any other substance abuse disorder; still, the underlying mechanisms are not fully established. To this end, we studied acute effects by nicotine on neurotransmission in the dor…