Holger Wille
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View article: Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs
Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs Open
Copolymers formed by non-alternating distributions of styrene and maleic acid monomers directly solubilize intact membranes into ∼10 nm discs. However, these copolymers are inherently polydisperse in terms of polymer structure, difficult t…
View article: Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions
Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions Open
These results, taken together, suggest that native PLGA nanoparticles can not only attenuate temperature-dependent tau aggregation but also promote disassembly of preformed aggregates, which increased with a rise of temperature. Given the …
View article: A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.
A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases. Open
Decades after their initial observation in prion-infected brain tissues, the identities of virus-like dense particles, varicose tubules, and oval bodies containing parallel bands and fibrils have remained elusive. Our recent work revealed …
View article: Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders
Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders Open
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein. Developing effectiv…
View article: Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson’s disease
Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson’s disease Open
The pathological misfolding and aggregation of soluble α-synuclein into toxic oligomers and insoluble amyloid fibrils causes Parkinson’s disease, a progressive age-related neurodegenerative disease for which there is no cure. HET-s is a so…
View article: Protein thermal sensing regulates physiological amyloid aggregation
Protein thermal sensing regulates physiological amyloid aggregation Open
To survive, cells must respond to changing environmental conditions. One way that eukaryotic cells react to harsh stimuli is by forming physiological, RNA-seeded subnuclear condensates, termed amyloid bodies (A-bodies). The molecular const…
View article: SERS probing of fungal HET-s fibrils formed at neutral and acidic pH conditions
SERS probing of fungal HET-s fibrils formed at neutral and acidic pH conditions Open
Advances in precision medical diagnostics require accurate and sensitive characterization of pathogens. In particular, health conditions associated with protein misfolding require an identification of proteinaceous amyloid fibrils or their…
View article: In Vitro and In Vivo Evidence towards Fibronectin’s Protective Effects against Prion Infection
In Vitro and In Vivo Evidence towards Fibronectin’s Protective Effects against Prion Infection Open
A distinctive signature of the prion diseases is the accumulation of the pathogenic isoform of the prion protein, PrPSc, in the central nervous system of prion-affected humans and animals. PrPSc is also found in peripheral tissues, raising…
View article: Propagation of PrPSc in mice reveals impact of aggregate composition on prion disease pathogenesis
Propagation of PrPSc in mice reveals impact of aggregate composition on prion disease pathogenesis Open
Infectious prions consist of PrP Sc , a misfolded, aggregation-prone isoform of the host’s prion protein. PrP Sc assemblies encode distinct biochemical and biological properties. They harbor a specific profile of PrP Sc species, from small…
View article: Fibronectin: a natural barrier against prion infection
Fibronectin: a natural barrier against prion infection Open
A distinctive signature of the prion diseases is the accumulation of the pathogenic isoform of the prion protein, PrP Sc , in the central nervous system of prion-affected humans and animals. PrP Sc is also found in peripheral tissues, rais…
View article: Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson’s disease and related disorders
Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson’s disease and related disorders Open
Background Synucleinopathies, including Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies, are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. Developing effective vacc…
View article: Issue Information
Issue Information Open
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View article: Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation Open
The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we cros…
View article: Somatostatin slows Aβ plaque deposition in aged <i>APP<sup>NL-F/NL-F</sup></i> mice by blocking Aβ aggregation in a neprilysin-independent manner
Somatostatin slows Aβ plaque deposition in aged <i>APP<sup>NL-F/NL-F</sup></i> mice by blocking Aβ aggregation in a neprilysin-independent manner Open
The molecular underpinnings that govern the endoproteolytic release of the amyloid beta peptide (Aβ) from the amyloid precursor protein (APP) are now quite well understood. The same cannot be said for the events that precipitate the aggreg…
View article: Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology Open
Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play a critical role in the development of Alzheimer's disease (AD) pathology. Aβ-containing neuronal exosomes, which represent a novel form of intercellular commun…
View article: Biosynthesis of Silver Nanoparticles Using Stenocereus queretaroensis Fruit Peel Extract: Study of Antimicrobial Activity
Biosynthesis of Silver Nanoparticles Using Stenocereus queretaroensis Fruit Peel Extract: Study of Antimicrobial Activity Open
The synthesis and application of nanomaterials as antioxidants and cytotoxic agents has increased in recent years. Biological methods go beyond the chemical and physical synthesis that is expensive and not friendly to the environment. Food…
View article: New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene
New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene Open
Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the prion protein gene can result in extended survival of CWD-infected animals. However, the impact of polymorphisms on cellular prion protein (PrP C ) an…
View article: Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm
Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm Open
Prion diseases are transmissible neurodegenerative disorders that affect mammals, including humans. The central molecular event is the conversion of cellular prion glycoprotein, PrP C , into a plethora of assemblies, PrP Sc , associated wi…
View article: The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models Open
Bovine spongiform encephalopathy (BSE) is a prion disease of cattle that is caused by the misfolding of the cellular prion protein (PrP C ) into an infectious conformation (PrP Sc ). PrP C is a predominantly α-helical membrane protein that…
View article: Aggregation of Aβ40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations
Aggregation of Aβ40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations Open
Alzheimer’s disease is associated with the formation of toxic aggregates of amyloid beta (Aβ) peptides. Despite tremendous efforts, our understanding of the molecular mechanisms of aggregation, as well as cofactors that might influence it,…
View article: Multisite interactions of prions with membranes and native nanodiscs
Multisite interactions of prions with membranes and native nanodiscs Open
Although prions are known as protein-only infectious particles, they exhibit lipid specificities, cofactor dependencies and membrane-dependent activities. Such membrane interactions play key roles in how prions are processed, presented and…
View article: Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy Open
Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood,…
View article: Author response: Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
Author response: Seizures are a druggable mechanistic link between TBI and subsequent tauopathy Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Traumatic brain injury (TBI) …