Holly E. Dembinski
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View article: Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant Open
Significance Stress-response transcription factors turn on hundreds of genes, and their activity must be turned off completely and quickly. The inhibitor protein IκBα turns off NFκB by forming a transient ternary complex with the NFκB–DNA …
View article: The Role of IkappaBalpha and DNA binding in NFkappaB Regulation, Dynamics, and Function
The Role of IkappaBalpha and DNA binding in NFkappaB Regulation, Dynamics, and Function Open
Nuclear factor kappa B (NFkappaB) transcription factors are responsible for the regulation of hundreds of target genes, their expression is induced by many classes of stimuli, and NFkappaBs play essential roles in the healthy regulation of…