Kam‐Lun Ellis Hon
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View article: Immune Benefits of Psychosocial Intervention for Atopic Dermatitis in Hong Kong Children
Immune Benefits of Psychosocial Intervention for Atopic Dermatitis in Hong Kong Children Open
Purpose: To evaluate the efficacy of an Integrative Body–Mind–Spirit (IBMS) group intervention in modulating inflammatory cytokine balance and improving clinical outcomes in children with atopic dermatitis. Methods: In a randomized, waitli…
View article: Status Epilepsy Syndromes Made Easy: Pediatric Perspectives
Status Epilepsy Syndromes Made Easy: Pediatric Perspectives Open
Introduction: Refractory Status Epilepsy Syndrome is a heterogeneous group of diseases associated with status epilepsy. Literature and definition have been conflicting and confusing in terms of their nomenclatures. New-onset refractory sta…
View article: Netherton syndrome: effect on ichthyosis linearis circumflexa with dupilumab
Netherton syndrome: effect on ichthyosis linearis circumflexa with dupilumab Open
Our case illustrates promising response to dupilumab in terms of eczema and hair growth, as well as a significant drop in serum IgE level, but ichthyosis linearis circumflexa persists.
View article: The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury
The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury Open
Background There is limited data on applying urinary biomarkers for prediction of kidney outcomes in pediatric acute kidney injury (AKI). Methods We prospectively measured urinary neutrophil gelatinase-associated lipocalin (NGAL), tissue m…
View article: Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial
Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial Open
Background Allergic rhinitis (AR) is a common allergic condition characterized by frequent sneezing, nasal congestion, nasal itching and rhinorrhea. Chinese medicine formula Yu-Ping-Feng Powder with Variation (YPV) is an empirical formula …
View article: Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong
Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong Open
The study highlights the significant changes in respiratory virus epidemiology following the lifting of COVID-19 restrictions. Method: In this single-centre retrospective study, the virological readouts of adenovirus (AdV), influenza virus…
View article: Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs
Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs Open
Background: Invasive fungal infections (IFIs) are important infectious complications amongst critically ill children. The most common fungal infections are due to Candida species. Aspergillus, Zygomycetes and Fusarium are also emerging bec…
View article: Respiratory Viral Infection Patterns in Hospitalised Children before and after COVID-19 in Hong Kong
Respiratory Viral Infection Patterns in Hospitalised Children before and after COVID-19 in Hong Kong Open
In the wake of Hong Kong’s zero-COVID policy, this study comprehensively analyses the epidemiological shift in respiratory viruses among hospitalized pediatric patients. The research leverages a unique natural experiment created by the pol…
View article: Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children
Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children Open
Functional TGFB1 polymorphism is associated with both eczema and allergic rhinitis, suggesting the role of TGF-β1 in allergy susceptibility. IL10 may be associated with increased total IgE levels. Interaction among immune regulatory genes …
View article: OP35 Efficacy of mirikizumab in comparison to ustekinumab in patients with moderate to severe Crohn’s disease: Results from the phase 3 VIVID 1 study
OP35 Efficacy of mirikizumab in comparison to ustekinumab in patients with moderate to severe Crohn’s disease: Results from the phase 3 VIVID 1 study Open
Background The primary objective of the VIVID-1 trial (NCT03926130) was to demonstrate efficacy and safety of mirikizumab (miri), a p19-directed anti-IL-23 antibody, compared to placebo (PBO) in patients (pts) with moderate-to-severe Crohn…
View article: Comparison of paediatric basic life support guidelines endorsed by member councils of Resuscitation Council of Asia
Comparison of paediatric basic life support guidelines endorsed by member councils of Resuscitation Council of Asia Open
This was an overview and mapping of published Asian paediatric resuscitation algorithms. It highlights similarities across paediatric life support guidelines in Asian countries. There were some differences in components of paediatric life …
View article: Traditional Chinese medicine (Lianhua Qingwen) as an add-on to Western medicine for mild to moderate COVID-19 patients: A meta-analysis
Traditional Chinese medicine (Lianhua Qingwen) as an add-on to Western medicine for mild to moderate COVID-19 patients: A meta-analysis Open
Background: Proprietary traditional Chinese medicine (TCM) such as Lianhua Qingwen (LQ) has been promoted to be an over-the-counter product for treating infectious diseases including COVID-19. This meta-analysis aimed to evaluate the effic…
View article: Tinea pedis: an updated review
Tinea pedis: an updated review Open
Topical antifungal therapy (once to twice daily for 1-6 weeks) is the mainstay of treatment for superficial or localized tinea pedis. Examples of topical antifungal agents include allylamines (e.g. terbinafine), azoles (e.g. ketoconazole),…
View article: The pattern and prognostic factors for kidney function progression in children with acute kidney injury and acute kidney disease
The pattern and prognostic factors for kidney function progression in children with acute kidney injury and acute kidney disease Open
Background: There is a paucity of data describing the progression of kidney function from acute kidney injury (AKI) to acute kidney disease (AKD) among children. Methods: A prospective cohort study on pediatric AKI was conducted from 6/202…
View article: The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial
The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial Open
Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effect…
View article: Tinea versicolor: an updated review
Tinea versicolor: an updated review Open
Selection of antifungal agents depends on several factors, including efficacy, safety, local availability, ease of administration, likelihood of compliance and potential drug interactions of the antifungal agent.
View article: Enabling Factors, Barriers, and Perceptions of Pneumococcal Vaccination Strategy Implementation: A Qualitative Study
Enabling Factors, Barriers, and Perceptions of Pneumococcal Vaccination Strategy Implementation: A Qualitative Study Open
Invasive pneumococcal disease (IPD) is a leading cause of disability and mortality worldwide, particularly in the elderly population. With the implementation of the Government Vaccination Programme (GVP) and the Vaccination Subsidy Scheme …
View article: Drugs for paediatric hyperinflammatory syndromes
Drugs for paediatric hyperinflammatory syndromes Open
The incidence of these hyperinflammatory conditions is generally low in comparison to other disease conditions. Except for paediatric inflammatory multisystem syndrome/MIS-C, the mortality is high and the hospital stay is prolonged in affe…
View article: Successful Treatment of Drug-Resistant Seizures Secondary to Ring 20 Mosaicism with Perampanel as an Add-On Antiepileptic Drug
Successful Treatment of Drug-Resistant Seizures Secondary to Ring 20 Mosaicism with Perampanel as an Add-On Antiepileptic Drug Open
We report a girl with drug-resistant seizures, progressive behavioral changes, and cognitive decline. Investigations showed abnormal EEG with frequent high-voltage bifrontotemporal sharp and slow waves, especially during sleep. Seizures we…
View article: Xeroderma pigmentosum: an updated review
Xeroderma pigmentosum: an updated review Open
Although currently there is no cure for xeroderma pigmentosum, increased awareness and early diagnosis of the condition, followed by rigorous sun avoidance and protection and optimal management, can dramatically improve the quality of life…
View article: Paediatrics: how to manage pediculosis capitis
Paediatrics: how to manage pediculosis capitis Open
Many topical pediculicides are effective for the treatment of pediculosis capitis. The use of some of these pediculicides is limited for safety reasons, especially in children younger than 2 years. Resistance to pediculicides, especially t…
View article: Neonatal COVID and Familial Hemophagocytic Lymphohistiocytosis
Neonatal COVID and Familial Hemophagocytic Lymphohistiocytosis Open
Hon, Kam Lun Ellis MBBS, MD, FAAP, FCCM; Leung, Karen Ka Yan MBBS, MSc; Hui, Wun Fung MBChB, MRCPCH; Cheung, Wing Lum MBBS, MRCPCH; Leung, Wing Hang MBBS, PhD Author Information
View article: Hepatitis E Virus Species C Infection in Humans, Hong Kong
Hepatitis E Virus Species C Infection in Humans, Hong Kong Open
Background Hepatitis E virus (HEV) variants belonging to Orthohepevirus species A (HEV-A) are the primary cause of human hepatitis E. However, we previously reported that Orthohepevirus species C genotype 1 (HEV-C1), a divergent HEV varian…
View article: Dermatology: how to manage acne vulgaris
Dermatology: how to manage acne vulgaris Open
Topical retinoids are the drugs of choice for the treatment and maintenance therapy of patients with mild-to-moderate acne vulgaris. Depending on the severity of the acne, topical retinoids may be used alone or in combination with benzoyl …
View article: The role of media messaging in COVID‐19 vaccine hesitancy amongst the student population: Friend or foe
The role of media messaging in COVID‐19 vaccine hesitancy amongst the student population: Friend or foe Open
The authors declare that there are no conflict of interests.
View article: Applying lessons from influenza pandemics to the COVID‐19 pandemic
Applying lessons from influenza pandemics to the COVID‐19 pandemic Open
All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
View article: Treatment with Methylphenidate for Attention Deficit Hyperactivity Disorder (ADHD) and the Risk of All-Cause Poisoning in Children and Adolescents: A Self-Controlled Case Series Study
Treatment with Methylphenidate for Attention Deficit Hyperactivity Disorder (ADHD) and the Risk of All-Cause Poisoning in Children and Adolescents: A Self-Controlled Case Series Study Open
The risk of all-cause poisoning was higher shortly before and after the first MPH prescription and became lower during the subsequent prescription period. Our results do not support an association between the use of MPH and an increased ri…