Xiaohong Chen
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View article: Metabolically hijacked Listeria monocytogenes synergizes STING activation and dual cell death for enhanced antitumor immunotherapy
Metabolically hijacked Listeria monocytogenes synergizes STING activation and dual cell death for enhanced antitumor immunotherapy Open
These findings establish metabolic hijacking of bacterial vectors as a paradigm-shifting strategy that integrates direct tumor killing with multimodal immune activation, overcoming key barriers in microbial immunotherapy.
View article: LLM-based cost-aware task scheduling for cloud computing systems
LLM-based cost-aware task scheduling for cloud computing systems Open
Cloud task scheduling faces significant challenges due to resource heterogeneity, conflicting optimization objectives, and dynamic workload fluctuations. Traditional heuristic algorithms often necessitate comprehensive knowledge of environ…
View article: Establishment of a Tissue Culture System for Quercus palustris
Establishment of a Tissue Culture System for Quercus palustris Open
Quercus palustris possesses significant ecological and ornamental value, yet its clonal propagation remains challenging, hindering germplasm utilization. To address this, an efficient tissue culture propagation system was established. This…
View article: Risk Assessment of Roof Water Inrush in Shallow Buried Thick Coal Seam Using FAHP-CV Comprehensive Weighting Method: A Case Study of Guojiawan Coal Mine
Risk Assessment of Roof Water Inrush in Shallow Buried Thick Coal Seam Using FAHP-CV Comprehensive Weighting Method: A Case Study of Guojiawan Coal Mine Open
Roof water inrush is a major hazard threatening coal mine safety. This paper addresses the risk of roof water inrush during mining in the shallow-buried Jurassic coalfield of Northern Shaanxi, taking the Guojiawan Coal Mine as a case study…
View article: Disparities in urban vegetation degradation and heat exposure during drought periods in U.S. cities
Disparities in urban vegetation degradation and heat exposure during drought periods in U.S. cities Open
Policymakers are increasingly recognizing the necessity for the equitable distribution of urban green spaces across sociodemographic groups. Nevertheless, the extant research consistently highlights disparities in this allocation, frequent…
View article: Impact of Non‐Alcoholic Fatty Liver Disease on the <scp>HBsAg</scp> Loss of Patients With Chronic Hepatitis B Treated in Pegylated Interferon Alpha
Impact of Non‐Alcoholic Fatty Liver Disease on the <span>HBsAg</span> Loss of Patients With Chronic Hepatitis B Treated in Pegylated Interferon Alpha Open
Whether combining non‐alcoholic fatty liver disease (NAFLD) affects the efficacy of pegylated interferon alpha (PEG‐IFN‐α) for patients with chronic hepatitis B (CHB) remains unknown; hence, we aimed to conduct a retrospective cohort study…
View article: Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies
Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies Open
Antiphospholipid syndrome (APS) is a systemic autoimmune disease. When pathological pregnancy manifestations—such as recurrent miscarriage, stillbirth, preeclampsia, and preterm birth—predominate, the condition is called obstetric APS (OAP…
View article: Genetic susceptibility to gestational diabetes and its mild modification by bisphenol A and thyroid-stimulating hormone: findings from a South Chinese pregnancy cohort
Genetic susceptibility to gestational diabetes and its mild modification by bisphenol A and thyroid-stimulating hormone: findings from a South Chinese pregnancy cohort Open
Background Gestational diabetes mellitus (GDM) is a multifaceted and complex condition. Genetic factors, maternal exposure to bisphenol A (BPA), and thyroid-stimulating hormone (TSH) levels have been associated with GDM. However, existing …
View article: Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion Open
Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated …
View article: Inhibition of ginsenoside Re on pulmonary fibrosis induced by bleomycin in mice: Involved in modulating the CX3CL1/CX3CR1 axis
Inhibition of ginsenoside Re on pulmonary fibrosis induced by bleomycin in mice: Involved in modulating the CX3CL1/CX3CR1 axis Open
Pulmonary fibrosis (PF) is a common pathological feature of a variety of diffuse, progressive and irreversible pulmonary interstitial diseases, and effective therapeutic agents are currently lacking. Our previous study found that the total…
View article: Origin and adaptive evolutionary trajectory of the 3′ UTR–derived sRNA UhpU in Enterobacteriaceae
Origin and adaptive evolutionary trajectory of the 3′ UTR–derived sRNA UhpU in Enterobacteriaceae Open
Bacterial small RNAs (sRNAs) derived from mRNA 3′ untranslated regions (3′ UTRs) have emerged as important regulators of gene expression, yet their evolutionary origins and functional diversification remain poorly understood compared to th…
View article: Study of Ice Load on Hull Structure Based on Full-Scale Measurements in Bohai Sea
Study of Ice Load on Hull Structure Based on Full-Scale Measurements in Bohai Sea Open
Ice load is a crucial factor when designing structures for polar vessels. Due to the unpredictable nature of sea ice mechanics and the complexity of ship structures, obtaining ice load characteristics through full-scale measurements is con…
View article: Impact of surgery on survival in TNBC with bone metastases only: a propensity score-matched SEER database analysis
Impact of surgery on survival in TNBC with bone metastases only: a propensity score-matched SEER database analysis Open
In TNBC patients with bone metastases only, compared to the non-surgery group, the primary site surgery group shows longer OS and CSS. Surgery combined with systemic treatment is a preferable treatment option.
View article: Body Roundness Index Versus Body Mass Index: Differential Associations With Obstructive Sleep Apnea Syndrome and All‐Cause Mortality in US Adults Aged 20 Years and Older
Body Roundness Index Versus Body Mass Index: Differential Associations With Obstructive Sleep Apnea Syndrome and All‐Cause Mortality in US Adults Aged 20 Years and Older Open
Background Being obese considerably elevates the risk of both obstructive sleep apnea syndrome (OSAS) and mortality. Although body mass index (BMI) is a common measure, it neglects visceral adiposity, a critical factor in the development o…
View article: Cardiac Angiosarcoma With Lung Metastasis Presenting as Granuloma‐Like Lesions: One Case Report and Literature Review
Cardiac Angiosarcoma With Lung Metastasis Presenting as Granuloma‐Like Lesions: One Case Report and Literature Review Open
Metastatic pulmonary angiosarcoma exhibits highly heterogeneous clinical, imaging and pathological features, with an extremely poor prognosis. This case report describes a 30‐year‐old woman who presented with recurrent hemoptysis and multi…
View article: Adaptive Challenges of Past and Future Invasion of <i>Drosophila suzukii</i> : Insights From Novel Genomic Resources and Statistical Methods Combining Individual and Pool Sequencing Data
Adaptive Challenges of Past and Future Invasion of <i>Drosophila suzukii</i> : Insights From Novel Genomic Resources and Statistical Methods Combining Individual and Pool Sequencing Data Open
Global change is accelerating biological invasions, making it crucial to understand how species adapt in new environments to improve management strategies. Genomic data provide valuable insights into adaptation through genotype‐environment…
View article: Comparative Analysis of Environmental and Host-Associated Microbiome in Odorrana schmackeri (Auran: Ranidae): Insights into Tissue-Specific Colonization and Microbial Adaptation
Comparative Analysis of Environmental and Host-Associated Microbiome in Odorrana schmackeri (Auran: Ranidae): Insights into Tissue-Specific Colonization and Microbial Adaptation Open
Amphibian microbial communities are known to be shaped by host physiology and environmental factors, yet the relative roles of sexual dimorphism and tissue specialization remain poorly understood. Using 16S rRNA gene sequencing, we compare…
View article: ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β‑cells
ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β‑cells Open
Lipotoxicity-induced β-cell dysfunction is a critical contributor to the pathogenesis of type 2 diabetes mellitus. The aim of the present study was to investigate the role of endoplasmic reticulum-resident protein 46 (ERp46) in regulating …
Structural pharmacology of SV2A reveals an allosteric modulation mechanism in the major facilitator superfamily Open
The synaptic vesicle glycoprotein 2A (SV2A), a member of the major facilitator superfamily (MFS), is a key target for antiseizure medications and a biomarker for synaptic density imaging. Despite its clinical importance, the mechanisms und…
View article: NSD2 targeting reverses plasticity and drug resistance in prostate cancer
NSD2 targeting reverses plasticity and drug resistance in prostate cancer Open
Lineage plasticity is a cancer hallmark that drives disease progression and treatment resistance1,2. Plasticity is often mediated by epigenetic mechanisms that may be reversible; however, there are few examples of such reversibility. In ca…
View article: A real geographical case study on superconducting cables for high speed railway with electromagnetic and environmental analysis
A real geographical case study on superconducting cables for high speed railway with electromagnetic and environmental analysis Open
High-speed railways offer significant benefits such as high speed and large passenger capacity. However, their overall energy consumption continues to increase with network expansion. High-temperature superconducting (HTS) cables represent…
View article: Effects of Different Forms of Selenium in Human Umbilical Cord Mesenchymal Stem Cells
Effects of Different Forms of Selenium in Human Umbilical Cord Mesenchymal Stem Cells Open
Background: Mesenchymal stem cells (MSCs) have shown positive therapeutic effects on various diseases; however, their functionality can decline during in vitro expansion. Selenium (Se) supplementation has emerged as a strategy for enhancin…
View article: Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway
Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway Open
Background Epimedium brevicornu : Maxim., a traditional Chinese botanical drug, has shown significant therapeutic effects against hepatocellular carcinoma (HCC), with its flavonoid compounds exhibiting anti-HCC activity through various mec…