Hongjuan He
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View article: Effects of Adverse Childhood Experiences on Depression Among Chinese College Students: A Mediated Moderation Model of “Shift-and-Persist” Strategy and Perceived Everyday Discrimination
Effects of Adverse Childhood Experiences on Depression Among Chinese College Students: A Mediated Moderation Model of “Shift-and-Persist” Strategy and Perceived Everyday Discrimination Open
(1) Background: the influence of adverse childhood experiences (ACEs) on depression is well-documented. Identifying protective factors to counteract ACEs’ detrimental effects is vital for public mental health. The efficacy of the “shift-an…
View article: The Suppressing Effect of Self-Presentation on Social Networks on the Relationship Between Interpersonal Distress and Emotional Experience Among Late Adolescents in a Chinese University: The Moderating Role of Internet Addiction Tendency
The Suppressing Effect of Self-Presentation on Social Networks on the Relationship Between Interpersonal Distress and Emotional Experience Among Late Adolescents in a Chinese University: The Moderating Role of Internet Addiction Tendency Open
This study investigates how self-presentation on social networks suppresses the relationship between interpersonal distress and emotional experience among college students. It also examines the moderating role of internet addiction tendenc…
View article: In-vitro and in-vivo Anti-allergic Effect of Astragalus Membranaceus Ethanol Extract against Ragweed-induced Allergic Rhinitis by Down-regulating ERK and STAT3 Expression
In-vitro and in-vivo Anti-allergic Effect of Astragalus Membranaceus Ethanol Extract against Ragweed-induced Allergic Rhinitis by Down-regulating ERK and STAT3 Expression Open
View article: Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver Open
View article: DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression
DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression Open
View article: LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic Heart Development
LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic Heart Development Open
The Dlk1-Dio3 domain is important for normal embryonic growth and development. The heart is the earliest developing and functioning organ of the embryo. In this study, we constructed a transcriptional termination model by inserting termina…
View article: Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature
Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature Open
The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here, we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential for placentation. PolyA signals were inserted into Gtl2 to establ…
View article: N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst
N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst Open
View article: Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice
Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice Open
Meg8-DMR is the first maternal methylated DMR to be discovered in the imprinted Dlk1-Dio3 domain. The deletion of Meg8-DMR enhances the migration and invasion of MLTC-1 depending on the CTCF binding sites. However, the biological function …
View article: Deletion of Meg8-DMR Enhances Migration and Invasion of MLTC-1 Depending on the CTCF Binding Sites
Deletion of Meg8-DMR Enhances Migration and Invasion of MLTC-1 Depending on the CTCF Binding Sites Open
The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains three well-characterized paternally methylated differentially methylated regions (DMRs): IG-DMR, Gtl2-DMR, and Dlk1-DMR. These DMRs control the expression of many genes involve…
View article: Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome
Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome Open
Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in cancer or to germline mutations that are transmitted to the next generation. It is not k…
View article: m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling Open
View article: EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2
EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2 Open
View article: Transcriptomic Analyses Revealed Key Genes Linked To Berberine Selective Suppression Of IgE, But Not IgG In vivo And In vitro
Transcriptomic Analyses Revealed Key Genes Linked To Berberine Selective Suppression Of IgE, But Not IgG In vivo And In vitro Open
View article: A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth
A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth Open
View article: C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes
C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes Open
Musclin is a muscle-secreted cytokine that disrupts glucose uptake and glycogen synthesis in type 2 diabetes. The purpose of this study was to investigate the mechanisms responsible for the regulation of musclin gene expression in response…
View article: C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes
C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes Open
Supplemental Table S1 Quantitative real-time PCR primers.Supplemental Table S2 Sh-RNA interference sequences.Supplemental Table S3 sg RNAs sequences.
View article: Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study
Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study Open
BACKGROUND: Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identi…
View article: Baicalin inhibits breast cancer development via inhibiting IĸB kinase activation in vitro and in vivo
Baicalin inhibits breast cancer development via inhibiting IĸB kinase activation in vitro and in vivo Open
The aim of the present study was to investigate the effect and therapeutic potential of baicalin in breast cancer. Baicalin is used to treat inflammatory diseases. The effects of baicalin were assessed in breast cancer MCF-7 and MDA-MB‑231…
View article: High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database
High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database Open
The aim of this study was to evaluate the role of vimentin expression in the prognosis and progression of CRC. Meta-analysis was conducted to investigate the correlations between vimentin and prognosis and clinicopathological features in C…
View article: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis Open
The main purpose of this study was to perform a meta-analysis to assess the interaction between smoking and nine genes (GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, SULT1A1, hOGG1, XRCC1 and
View article: The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes
The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes Open
Sporadic colorectal cancer (sCRC) is one of the most commonly diagnosed cancers worldwide, but few genetic markers have been identified and used for its early detection. MicroRNAs are diverse cellular regulators in cancer pathogenesis that…
View article: Computational identification of putative lincRNAs in mouse embryonic stem cell
Computational identification of putative lincRNAs in mouse embryonic stem cell Open
View article: Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both <i>in vitro</i> and <i>in vivo</i>
Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both <i>in vitro</i> and <i>in vivo</i> Open
Ras-association domain family protein 6 (RASSF6) is a member of tumor suppressor RASSFs family with a wide range of function from RAS interaction, Hippo signaling involvement to cell cycle and apoptosis regulation. RASSF6 is reported inact…
View article: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct
Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct Open
View article: MiR-1188 at the imprinted<i>Dlk1-Dio3</i>domain acts as a tumor suppressor in hepatoma cells
MiR-1188 at the imprinted<i>Dlk1-Dio3</i>domain acts as a tumor suppressor in hepatoma cells Open
The aberrant expression of microRNAs (miRNAs) has frequently been reported in cancer studies; miRNAs play roles in development, progression, metastasis, and prognosis. Recent studies indicate that the miRNAs within the Dlk1-Dio3 genomic re…