Explanipedia

A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus Open

Hanluo Li, Qi Chen, Yuansheng Wang, Wei Yi, Peipei Guo , et al. · 2025

Replication of Gino, Shu, and Bazerman (2010, Study 2) Open

Sophia Li, Don A. Moore, Kanghong Hu, max bazerman · 2025

We attempted to replicate Study 2 from Gino et al. (2010). The original result finds evidence for an outcome bias, in which influence of chance on outcomes drives observers’ ratings of a decision’s ethicality, especially when the victim is…

(013) Glycated Serum Albumin Decreases Connexin 43 Phosphorylation in the Corpus Cavernosum Open

Yanping Huang, Wei Liu, Ye Liu, Ming Zhang, Kanghong Hu , et al. · 2024

Introduction Glycated serum albumin (GSA) is an early glycosylation product that participates in diabetic vascular complications, including retinopathy, nephropathy, neuropathy, and coronary artery disease. Elevated GSA levels and the asso…

Investigating the Nexus of NLRP3 Inflammasomes and COVID-19 Pathogenesis: Unraveling Molecular Triggers and Therapeutic Strategies Open

Qun He, Da Hu, Fuqiang Zheng, Wenxuan Chen, Kanghong Hu , et al. · 2024

The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases demonstrating a “cytokine storm”, an upsurge of pro-inflammatory cytokine…

Global m6A methylation and gene expression patterns in human microglial HMC3 cells infected with HIV-1 Open

Qian Peng, Jialu Qiao, Weiling Li, Qiang You, Song Hu , et al. · 2023

N6-methyladenosine (m6A) methylation of human immunodeficiency virus type 1 (HIV-1) RNA regulates viral replication, and the m6A of host RNA is affected by HIV-1 infection, but its global pattern and function are still unclear. In this stu…

Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors Open

Rominah Onintsoa Diarimalala, Yanhong Wei, Da Hu, Kanghong Hu · 2023

Corona Virus Disease 2019 (COVID-19) continues to be a burden for human health since its outbreak in Wuhan, China in December 2019. Recently, the emergence of new variants of concerns (VOCs) is challenging for vaccines and drugs efficiency…

Antiviral effects and mechanisms against EV71 of the novel 2-benzoxyl-phenylpyridine derivatives Open

Yanhong Wei, Da Hu, Dong Li, Kanghong Hu, Qian Zhang , et al. · 2023

A series of 2-Benzoxyl-Phenylpyridine derivatives were evaluated for their potential antiviral activities against EV71. The preliminary assays indicated that some of these compounds exhibited excellent antiviral effects on EV71, they could…

EV-A71 Mechanism of Entry: Receptors/Co-Receptors, Related Pathways and Inhibitors Open

Kanghong Hu, Rominah Onintsoa Diarimalala, Chenguang Yao, Hanluo Li, Yanhong Wei · 2023

Enterovirus A71, a non-enveloped single-stranded (+) RNA virus, enters host cells through three stages: attachment, endocytosis and uncoating. In recent years, receptors/co-receptors anchored on the host cell membrane and involved in this …

Legume-Derived Bioactive Peptides in Type 2 Diabetes: Opportunities and Challenges Open

Kanghong Hu, Huizhong Huang, Hanluo Li, Yanhong Wei, Chenguang Yao · 2023

Diabetes mellitus is a complex disorder characterized by insufficient insulin production or insulin resistance, which results in a lifelong dependence on glucose-lowering drugs for almost all patients. During the fight with diabetes, resea…

Identification of CFHR4 associated with poor prognosis of hepatocellular carcinoma Open

Qinglin Ding, Hanluo Li, Zhigao Xu, Kanghong Hu, Qifa Ye · 2022

Background Hepatocellular carcinoma (HCC) is one of the most leading causes of cancer death worldwide. The 5-year survival rate of HCC patients remains low due to the lack of early-stage symptoms. Human complement factor H-related protein …

Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates Open

Longsheng Wang, Chao Guo, Da Hu, Yanxi Zhao, Huihui Liu , et al. · 2022

A class of iodobenzoyldiazenido-functionalized POMs (TBA) 3 [Mo 6 O 18 (=N=NCOAr)] (Ar = Ph- o -I (1) ; Ph- m -I (2) ; Ph- p -I (3) ; Ph-3,4-I 2 (4) ; Ph-2,3,5-I 3 (5) (TBA = tetrabutylammonium) were prepared via the refluxing reaction of …

Lane Line Extraction in Raining Weather Images by Ridge Edge Detection with Improved MSR and Hessian Matrix Open

W. Wang, F. Berholm, Kanghong Hu, Li Jun Zhao, Feng Shang , et al. · 2021

To accurately detect lane lines in road traffic images at raining weather, a edge detection based method is studied, which mainly includes four algorithms. (1) Firstly an image is enhanced by an improved Retinex algorithm; (2) Then, an alg…

Identification of CFHR4 Associated With Poor Prognosis of Hepatocellular Carcinoma Open

Qinglin Ding, Zhigao Xu, Hanluo Li, Kanghong Hu, Qifa Ye · 2021

Background: Hepatocellular carcinoma (HCC) is one of the most leading causes of cancer death worldwide. The 5-year survival rate of HCC patients remains low due to the lack of early-stage symptoms. Human complement factor H-associated prot…

Chondromalacia patellae: current options and emerging cell therapies Open

Weitao Zheng, Hanluo Li, Kanghong Hu, Liming Li, Mingjian Bei · 2021

Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ targeting Inhibitors Open

Rominah Onintsoa Diarimalala, Meichun Hu, Yanhong Wei, Kanghong Hu · 2020

Eukaryotic initiation factor 3e subunit is positively associated with tumorigenesis and development of hepatocellular carcinoma Open

Shan Zhang, Zhongwei Chen, Shi-Min Meng, Qinglin Ding, Zibiao Zhong , et al. · 2020

Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives Open

Yanhong Wei, Haijie Wang, Caili Xi, Li Ni, Dong Li , et al. · 2020

Coxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant cause of morbidity and mortality worldwide, in people of all ages. A…

Inhibition of enterovirus 71 replication and viral 3C protease by quercetin Open

Chenguang Yao, Caili Xi, Kanghong Hu, Wa Gao, Xiaofeng Cai , et al. · 2018

Correction for Pan et al., Later Passages of Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection Open

Xing Pan, Xiaojun Li, Xiaojian Liu, Hui Yuan, Jiafu Li , et al. · 2016

Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide Open

Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai , et al. · 2016

Entry inhibitors are promising novel antivirals against hepatitis B virus (HBV) infection. The existing potential entry inhibitors have targeted the cellular receptor(s). In this study, we aim to develop the first entry inhibitor that inhi…

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide Open

Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu , et al. · 2015

A synthetic peptide octaarginine which mimics human immunodeficiency virus‐1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH…

Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines Open

Zhikui Cheng, Xiaoguang Zhi, Ge Sun, Wei Guo, Yayun Huang , et al. · 2015

Hepatitis B virus (HBV) infection is one of the most serious and prevalent health problems worldwide. Current anti‐HBV medications have a number of drawbacks, such as adverse effects and drug resistance; thus, novel potential anti‐HBV reag…

Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines Open

Zhikui Cheng, Ge Sun, Wei Guo, Yayun Huang, Weihua Sun , et al. · 2015

Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model Open

Danzhen Pan, Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang , et al. · 2015

Hydrodynamic injection (HI) with a replication competent hepatitis B virus (HBV) genome may lead to transient or prolonged HBV replication in mice. However, the prolonged HBV persistence after HI depends on the specific backbone of the vec…

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