Explanipedia

Intrinsic and extrinsic factors affecting the evolution of virulence in the HIV-associated opportunistic human fungal pathogen <i>Cryptococcus neoformans</i>. Open

Yuanyuan Wang, Yiwu Yu, Jihong Liu, Linghua Li, Xiaohong Chen , et al. · 2025

The fungus Cryptococcus neoformans is considered the leading cause of mortality in immunocompromised patients. While extensive research has unveiled the molecular epidemiology of C. neoformans, the influence of genetic and en…

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366 Open

Xuemei Liu, De‐cheng Deng, Jian Meng, Haitang Hu, Quankun Zhuang , et al. · 2025

Introduction JP-1366 (zastaprazan), a novel potassium-competitive acid blocker (P-CAB), was approved in South Korea in 2024 for treating erosive gastroesophageal reflux disease (GERD). This mass balance study characterized the pharmacokine…

Impact of energy metabolism pathways in promoting phytoremediation of cadmium contamination by Bacillus amyloliquefaciens Bam1 Open

Xuefan Jiang, Xiaohong Chen, Hongxia Gao, Jinyan Luo, Lin Zhang , et al. · 2025

Cuproptosis as a regulator in human diseases: From basic mechanisms to clinical relevance Open

Xiaohong Chen, Luanluan Huang, Ruiqi Liu, Nan Ding, Yucheng Li , et al. · 2025

Cuproptosis is a novel, copper-dependent regulated cell death (RCD) pathway identified in 2022. It is distinct from other forms of cell death, such as ferroptosis, due to its unique mechanism involving mitochondrial copper overload, aggreg…

Interdependence of government expenditure among European countries: Productivity spillover and strategic interaction Open

Xiaohong Chen, Haoming Mi, Peng Zhou · 2025

We build an endogenous growth model that distinguishes productive and welfare government expenditures and embeds fiscal externalities. The model yields three testable hypotheses: (i) productive expenditure raises growth (Barro effect); (ii…

Moral conflicts in home-based care: a meta-synthesis of qualitative research Open

Qi Fan He, Xiaohong Chen, Jing Cai, Lei Wang, Fang Wang · 2025

Identification methods for low-amplitude structures in Oilfield A Open

Aihua Guo, Pengfei Lu, Xi Zhang, Xiaohong Chen, Shuhao Jiang , et al. · 2025

During the exploration and development of Oilfield A, the formation dip revealed by drilling data showed certain differences from the structure map predicted by conventional structural interpretation and mapping methods. This indicated tha…

Topical issue on applied physics of superconductors in high-power applications Open

Xiaohong Chen, Lin Fu, Boyang Shen, Junzhi Ye · 2025

Engineered virus-hunter vaccine overcomes HBV immune tolerance Open

Xiaohong Chen, Xue Liu, Tao Xu, Yalin Wang, Peng Wang , et al. · 2025

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying substantial risks of liver fibrosis, cirrhosis and hepatocellular carcinoma. Fewer than 20% of patients receiving nucle…

Vision-language foundation model-driven efficient recognition and home-based management of surgical incisions Open

Chunlin Zhao, Huahui Yi, Zekun Jiang, Mei Yang, Yi Yang , et al. · 2025

Objective: Accurate assessment of surgical incision recovery is crucial for home-based care and rehabilitation of patients. This study aims to develop and evaluate a novel surgical incision recognition method driven by a Vision-Language Fo…

Portable Brain Computer Interface Sleep Monitor Compared with Polysomnography in Macroscopic and Microscopic Sleep Structures Open

Zijian Wang, Chenhao Zhao, Xiaoyu Bao, Junbiao Zhu, Kaixiu Jin , et al. · 2025

Accurate assessment of both macroscopic and microscopic sleep structure is critical for diagnosing sleep disorders and advancing personalized interventions. However, most existing portable sleep-monitoring devices, while validated at the m…

BIOM-51. DETECTION OF PD-L1 IN CEREBROSPINAL FLUID OF LEPTOMENINGEAL METASTASIS FROM SOLID TUMORS BASED ON THINPREP CYTOLOGY Open

Guozi Yang, Zhenyu Pan, Hanran Lei, Yushan Huang, Min Liu , et al. · 2025

BACKGROUND This study assessed the feasibility of PD-L1 detection via ThinPrep cytology and explored its application in cerebrospinal fluid (CSF) from leptomeningeal metastasis (LM) patients. METHODS Six human tumor cell lines (lung, breas…

Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPARγ activation in zebrafish: A comparative study with polymers and oligomers Open

Hongyi Xian, Ruobing Bai, Yujie Feng, Shiyue Tang, Zhiming Li , et al. · 2025

Polylactic acid (PLA), a biodegradable plastic, is increasingly promoted as a sustainable alternative to conventional plastics. However, its degradation under non-composting conditions and associated toxicological impacts remain insufficie…

127 Detection of PD-L1 in cerebrospinal fluid of leptomeningeal metastasis from solid tumors based on ThinPrep cytology Open

Guozi Yang, Zhenyu Pan, Hanran Lei, Yushan Huang, Min Liu , et al. · 2025

583 Intrathecal PD-1 inhibitor combined with pemetrexed for leptomeningeal metastases from solid tumors: preliminary results from a phase I/II study (NCT 06462222) Open

Zhenyu Pan, Guozi Yang, Miao Liu, Yu‐Shan Huang, Min Liu , et al. · 2025

Mechanocatalytic Hydrogen Evolution on Centrosymmetric SnS Nanobelts: A Non-Piezoelectric Pathway Open

Xiaotong Sun, Ming-Yang Chen, Bowen Zhang, Yawei Liu, Qi Liu , et al. · 2025

Harnessing ubiquitous mechanical energy for chemical transformations is a grand challenge, primarily impeded by the crystallographic symmetry constraints of conventional piezocatalysts. Here, this long-standing paradigm is shattered by dem…

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis Open

Wenzhi Cai, Huaxuan Zhao, Panpan Wang, Xiaohong Chen, Yumeng Yang , et al. · 2025

To investigate the potential bidirectional causal relationship between specific blood metabolites and chronic periodontitis using Mendelian randomisation (MR). A two‐sample bidirectional MR analysis was conducted. Data on 1400 blood metabo…

Association between lipid accumulation product and bowel habits and inflammatory bowel disease: a cross-sectional study Open

Bowen Cheng, Yunfeng Huang, Fang Jia-sheng, Xiaohong Chen, Xuejun Zhou · 2025

This cross-sectional study examined the relationship between bowel disorders and the Lipid Accumulation Product (LAP), a novel marker of visceral adiposity and metabolic dysfunction calculated from waist circumference and fasting triglycer…

Gradient refractive index chalcogenide lens for lightweight infrared dual-band imaging systems Open

Yongnian Guan, Kelun Xia, Zhengxiang Gu, Senlin Yan, Xiaohong Chen , et al. · 2025

In this study, we report the development of Ge 15 Se 85−x Te x (GSTx) chalcogenide glass-based gradient refractive index (GRIN) lenses for lightweight dual-band infrared imaging systems. The GSTx glasses exhibit compatible thermal properti…

First detection of ultra-high energy emission from gamma-ray binary LS I +61 303 Open

Zhenfu Cao, F. Aharonian, Y. X. Bai, Yiwang Bao, D. Bastieri , et al. · 2025

We report the first detection of gamma-ray emission up to ultra-high-energy (UHE; $>$100 TeV) emission from the prototypical gamma-ray binary system LS I +61 303 using data from the Large High Altitude Air Shower Observatory (LHAASO). It i…

The co-impact of diabetes and psoriasis on mortality risk for all causes and specific causes Open

Na Liu, Xiaohong Chen · 2025

Diabetes and psoriasis are known to increase the risk of each other, yet their combined impact on long-term mortality remains unclear. This prospective cohort study examined the associations between the coexistence of diabetes and psoriasi…

A full life cycle biological clock based on routine clinical data and its impact in health and diseases Open

Kai Wang, Fei Liu, Wei Wu, Changxi Hu, Xian Shen , et al. · 2025

Aging research has primarily focused on adult aging clocks, leaving a critical gap in understanding a biological clock across the full life cycle, particularly during infancy and childhood. Here we introduce LifeClock, a biological clock m…

Tensile and thermal properties, and microstructural evolution of additive-manufactured CuCrZr alloy at elevated temperature Open

Haofeng Xie, Xiangpeng Tang, Fujia Sun, Rui Zhao, Gangqiang Li , et al. · 2025

The NtBAG5-CaM complex integrates Ca <sup>2+</sup> signals to regulate leaf senescence via the antioxidant system in tobacco Open

Langlang Zhang, Bing Hou, Xiaohong Chen, Xinghui Liu, Wen Xie , et al. · 2025

Leaf yellowing critically impacts tobacco quality and economic value. The Bcl-2-associated athanogene (BAG) gene family regulates plant development and senescence, yet the role of NtBAG5 in tobacco remains poorly understood. Here, we demon…

Classification of quantum-spin-hall topological phase in 2D photonic continuous media using electromagnetic parameters Open

Xin‐Tao He, Shuo-Shi Zhang, Xiaohong Chen, Jian‐Wen Dong · 2025

Refractive index is a fundamental electromagnetic (EM) parameter that can describe photonic continuous media (PCM) traditionally as either transparency or opacity. Recently, topological theory offers a new set of phases to characterize PCM…

Reovirus infection results in rice rhizosphere microbial community reassembly through metabolite-mediated recruitment and exclusion Open

Zhanbiao Li, W. Luo, H. Xie, Cuiping Mo, Bixia Qin , et al. · 2025

The findings indicate that arboviruses can strongly influence the belowground rhizosphere microbial assembly processes by modulating metabolite profiles to selectively recruit or exclude key microbial species. These taxa, in turn, play fun…

Front Cover Open

Wei Bin, Guoxiong Lu, Qunxing Li, Jianglong Zhong, Zhijun Xie , et al. · 2025

The cover image is based on the article Finder‐I for Locating Anterolateral Thigh Perforators in Head and Neck Reconstruction: A Diagnostic Study by Bin Wei et al., https://doi.org/10.1002/hed.28227 . image

Multi-regional feature integration on enhanced CT for lymph node metastasis prediction in gastric cancer: a novel radiomics approach Open

Ang Shi, Huaiqing Zhi, Dongze Wu, Wanda Cai, Yong Chen , et al. · 2025

Local Overidentification and Efficiency Gains in Modern Causal Inference and Data Combination Open

Xiaohong Chen, Haitian Xie · 2025

This paper studies nonparametric local (over-)identification, in the sense of Chen and Santos (2018), and the associated semiparametric efficiency in modern causal frameworks. We develop a unified approach that begins by translating struct…

A nomogram to predict hypoxemia in the post-anesthesia care unit after laparoscopic bariatric surgery Open

Min Wang, Yiting Li, Qianyi Gong, Yifan Xu, Xiaohong Chen , et al. · 2025

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