Fujun Yu
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View article: Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis
Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis Open
Liver fibrosis is a chronic disease leading to hepatocellular carcinoma and liver failure, posing a major global health challenge. Hepatic stellate cells (HSCs) differentiate into myofibroblasts, central to fibrosis progression, but curren…
View article: Psoas muscle CT radiomics-based machine learning models to predict response to infliximab in patients with Crohn’s disease
Psoas muscle CT radiomics-based machine learning models to predict response to infliximab in patients with Crohn’s disease Open
Psoas computerized tomography radiomics-based ML models effectively predict the response of patients with CD to IFX therapy, with the eXtreme Gradient Boosting model exhibiting superior performance.
View article: Occult: Optimizing Collaborative Communication across Experts for Accelerated Parallel MoE Training and Inference
Occult: Optimizing Collaborative Communication across Experts for Accelerated Parallel MoE Training and Inference Open
Mixture-of-experts (MoE) architectures could achieve impressive computational efficiency with expert parallelism, which relies heavily on all-to-all communication across devices. Unfortunately, such communication overhead typically constit…
View article: A hybrid machine learning model with attention mechanism and multidimensional multivariate feature coding for essential gene prediction
A hybrid machine learning model with attention mechanism and multidimensional multivariate feature coding for essential gene prediction Open
View article: A Case of Spontaneous Remission of Non‐Hodgkin's Lymphoma in the Lung
A Case of Spontaneous Remission of Non‐Hodgkin's Lymphoma in the Lung Open
A 72‐year‐old male with a lung lesion was diagnosed with non‐Hodgkin's lymphoma through percutaneous needle lung biopsy. The patient's lung tumor disappeared during follow‐up 4 months later without any standard antitumor treatments. This i…
View article: Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer
Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer Open
View article: Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN
Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN Open
View article: Predicting lncRNA-protein interactions using a hybrid deep learning model with dinucleotide-codon fusion feature encoding
Predicting lncRNA-protein interactions using a hybrid deep learning model with dinucleotide-codon fusion feature encoding Open
Long non-coding RNAs (lncRNAs) play crucial roles in numerous biological processes and are involved in complex human diseases through interactions with proteins. Accurate identification of lncRNA-protein interactions (LPI) can help elucida…
View article: Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease
Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease Open
All three nutritional indexes evaluated malnutrition to be an independent risk factor for IBD activity.
View article: L3-SMI as a predictor of overall survival in oesophageal cancer patients receiving PD-1 inhibitors combined with chemotherapy
L3-SMI as a predictor of overall survival in oesophageal cancer patients receiving PD-1 inhibitors combined with chemotherapy Open
Excessive muscle loss rather than muscle loss before and after administration of PD-1 inhibitors combined with chemotherapy is an important prognostic factor for therapeutic outcomes and OS in EC patients.
View article: AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis
AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis Open
AdipoRon has been validated for its ability to reverse liver fibrosis, yet the underlying mechanisms remain to be thoroughly investigated. Collagen, predominantly synthesized and secreted in hepatic stellate cells (HSCs), relies on glycine…
View article: The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma
The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma Open
View article: Combined OLA1 and CLEC3B Gene Is a Prognostic Signature for Hepatocellular Carcinoma and Impact Tumor Progression
Combined OLA1 and CLEC3B Gene Is a Prognostic Signature for Hepatocellular Carcinoma and Impact Tumor Progression Open
Hepatocellular carcinoma (HCC), partly because of its complexity and high heterogeneity, has a poor prognosis and an extremely high mortality rate. In this study, mRNA sequencing expression profiles and relevant clinical data of HCC patien…
View article: 2′-Hydroxycinnamaldehyde mitigates acetaminophen-induced acute liver injury by inhibiting the Warburg effect-mediated pyroptosis via the PKM2-NLRP3 axis
2′-Hydroxycinnamaldehyde mitigates acetaminophen-induced acute liver injury by inhibiting the Warburg effect-mediated pyroptosis via the PKM2-NLRP3 axis Open
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver injury. However, the underlying mechanisms appear to be multifaceted and there are few effective treatments. In this study, we used the 2′-Hydroxycinnamaldehyde…
View article: Identification of breast cancer subgroups and immune characterization based on glutamine metabolism-related genes
Identification of breast cancer subgroups and immune characterization based on glutamine metabolism-related genes Open
View article: Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation Open
Cisplatin (CPT) is one of the standard treatments for hepatocellular carcinoma (HCC). However, its use is limits as a monotherapy due to drug resistance, and the underlying mechanism remains unclear. To solve this problem, we tried using c…
View article: A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma Open
Taken together, the gene pair CSTF2/PDE2A is able to forecast the prognosis of HCC and regulates cell cycle, which is promising as a novel prognostic predictor of HCC.
View article: Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway Open
Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid peroxidation. Endoplasmic reticulum (ER) stress is a systemi…
View article: Awards
Awards Open
View article: Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database
Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database Open
Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with …
View article: A pyroptosis-related gene signature provides an alternative for predicting the prognosis of patients with hepatocellular carcinoma
A pyroptosis-related gene signature provides an alternative for predicting the prognosis of patients with hepatocellular carcinoma Open
View article: ASO Visual Abstract: A Glycolysis-Related Gene Signature Can Predict Survival and Immune Status of Hepatocellular Carcinoma
ASO Visual Abstract: A Glycolysis-Related Gene Signature Can Predict Survival and Immune Status of Hepatocellular Carcinoma Open
View article: Comprehensive Analysis Identified Mutation-Gene Signature Impacts the Prognosis Through Immune Function in Hepatocellular Carcinoma
Comprehensive Analysis Identified Mutation-Gene Signature Impacts the Prognosis Through Immune Function in Hepatocellular Carcinoma Open
Background Hepatocellular carcinoma (HCC) is a life-threatening and refractory malignancy with poor outcome. Genetic mutations are the hallmark of cancer. Thus far, there is no comprehensive prognostic model constructed by mutation-gene tr…
View article: Correction: LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212
Correction: LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212 Open
View article: Establishment and Validation of a Peroxisome-related Gene Signature for Prognostic Prediction and Immune Distinction in Hepatocellular Carcinoma
Establishment and Validation of a Peroxisome-related Gene Signature for Prognostic Prediction and Immune Distinction in Hepatocellular Carcinoma Open
Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Abnormal peroxisomes can promote the development of cancers. This study aimed to construct a prognostic…
View article: Casing Collapse Strength Analysis under Nonuniform Loading Using Experimental and Numerical Approach
Casing Collapse Strength Analysis under Nonuniform Loading Using Experimental and Numerical Approach Open
Multistage fracturing is the main means of shale gas development, and casing deformation frequently occurs during fracturing of shale gas horizontal wells. Fracturing fluid entering the formation will change in situ stress nearby the wellb…
View article: Pyroptosis-related genes IRAK1, NOD2, POP1 and YWHAB impact the prognosis through immune functional pathways in hepatocellular carcinoma
Pyroptosis-related genes IRAK1, NOD2, POP1 and YWHAB impact the prognosis through immune functional pathways in hepatocellular carcinoma Open
Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Pyroptosis can influence the proliferation, invasion and metastasis of tumors. However, the prognostic value o…
View article: A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion relat…
View article: An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma Open
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. As part of the active cross-talk between the tumor and the host, inflammatory response in the tumor or its micr…
View article: A Cell Division Cycle-Related Gene Signature Can Predict Prognosis and Distinguish Immune Status of Hepatocellular Carcinoma
A Cell Division Cycle-Related Gene Signature Can Predict Prognosis and Distinguish Immune Status of Hepatocellular Carcinoma Open