Hongbing Fan
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View article: Screening and Identification of Antioxidant Peptides from Sea Cucumber Gonad Proteins and Their Activation of Superoxide Dismutase
Screening and Identification of Antioxidant Peptides from Sea Cucumber Gonad Proteins and Their Activation of Superoxide Dismutase Open
The gonad is one of the major byproducts of sea cucumber. Four novel antioxidant peptides (NPWGQ, PGHPF, VPYPR and ATGPQGPAGQRGPAGPTGPTGPAG) were isolated and identified from sea cucumber gonad proteins through enzymatic hydrolysis and ant…
View article: Comparison of Alcohol-Induced Hepatoprotective Effects of the High Fischer Ratio Oligopeptides with/Without Half Substitution by Pueraria lobata
Comparison of Alcohol-Induced Hepatoprotective Effects of the High Fischer Ratio Oligopeptides with/Without Half Substitution by Pueraria lobata Open
Long-term excessive intake of alcohol can cause serious damage to the liver, and the study of natural active ingredients with hepatoprotective effects is of great significance for the prevention and treatment of alcoholic liver injury. Thi…
View article: Integrating EEM fluorescence spectroscopy with machine and deep learning models for multi-output prediction of fish freshness
Integrating EEM fluorescence spectroscopy with machine and deep learning models for multi-output prediction of fish freshness Open
View article: Maillard reaction upgrades silver carp hydrolysates into prebiotic with immunomodulatory potential: The synergistic effects on immune function and gut microenvironment
Maillard reaction upgrades silver carp hydrolysates into prebiotic with immunomodulatory potential: The synergistic effects on immune function and gut microenvironment Open
View article: Screening and Identification of Antioxidant Peptides from Sea Cucumber Gonad Proteins and Their Activation of Superoxide Dismutase
Screening and Identification of Antioxidant Peptides from Sea Cucumber Gonad Proteins and Their Activation of Superoxide Dismutase Open
View article: Food-Derived Up-Regulators and Activators of Angiotensin Converting Enzyme 2: A Review
Food-Derived Up-Regulators and Activators of Angiotensin Converting Enzyme 2: A Review Open
Angiotensin-converting enzyme 2 (ACE2) is a key enzyme in the renin-angiotensin system (RAS), also serving as an amino acid transporter and a receptor for certain coronaviruses. Its primary role is to protect the cardiovascular system v…
View article: Effect of simulated gastrointestinal digestion on antioxidant, and anti-inflammatory activities of bioactive peptides generated in sausages fermented with <i>Staphylococcus simulans</i> QB7
Effect of simulated gastrointestinal digestion on antioxidant, and anti-inflammatory activities of bioactive peptides generated in sausages fermented with <i>Staphylococcus simulans</i> QB7 Open
Dry-fermented sausages are a good source of bioactive peptides, whose stability against gastrointestinal (GI) digestion determines their bioaccessibility. This study focused on evaluating the effect of peptide extracts from sausages fermen…
View article: Noninvasive freshness evaluation of bighead carp heads based on fluorescence spectroscopy coupled with long short-term memory network: simulation of cold chains
Noninvasive freshness evaluation of bighead carp heads based on fluorescence spectroscopy coupled with long short-term memory network: simulation of cold chains Open
To swiftly and noninvasively assess the freshness of bighead carp heads within simulated cold chain environments, an excitation-emission matrix fluorescence spectroscopy coupled with a long short-term memory network (EEM-LSTM) model was de…
View article: Ovotransferrin-depleted egg white hydrolysate reduces blood pressure in spontaneously hypertensive rats
Ovotransferrin-depleted egg white hydrolysate reduces blood pressure in spontaneously hypertensive rats Open
Egg whites contain a variety of biologically active proteins and are a good source of bioactive peptides. Egg white hydrolysate prepared by thermoase (EWH) possesses antihypertensive effects. Our recent study showed that egg white proteins…
View article: Peptidomics Study of Plant-Based Meat Analogs as a Source of Bioactive Peptides
Peptidomics Study of Plant-Based Meat Analogs as a Source of Bioactive Peptides Open
The demand for plant-based meat analogs (PBMA) is on the rise as a strategy to sustain the food protein supply while mitigating environmental change. In addition to supplying essential amino acids and energy, food proteins are known source…
View article: Purification of Extracellular Protease from Staphylococcus simulans QB7and Its Ability in Generating Antioxidant and Anti-inflammatory Peptides from Meat Proteins
Purification of Extracellular Protease from Staphylococcus simulans QB7and Its Ability in Generating Antioxidant and Anti-inflammatory Peptides from Meat Proteins Open
Proteases, especially microbial proteases, are widely used in food processing. The purpose of this study was aimed to purify an extracellular protease produced by the strain Staphylococcus simulans QB7 and to evaluate its ability in hydrol…
View article: Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNFα-Induced Oxidative Stress and Inflammation via Modulating TNFα Receptors and SIRT1
Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNFα-Induced Oxidative Stress and Inflammation via Modulating TNFα Receptors and SIRT1 Open
Soybean is a rich source of high-quality proteins and an excellent food source of bioactive peptides. A tripeptide, Leu–Ser–Trp (LSW), was previously identified from soybean as an angiotensin-converting enzyme inhibitory peptide. In the pr…
View article: Conventional use and sustainable valorization of spent egg-laying hens as functional foods and biomaterials: A review
Conventional use and sustainable valorization of spent egg-laying hens as functional foods and biomaterials: A review Open
Spent hen are egg-laying hens reaching the end of their laying cycles; billions of spent hens are produced globally each year. Differences in people’s attitudes towards spent hen as foods lead to their different fates among countries. Whil…
View article: Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells
Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells Open
Spent hens are egg-laying hens reaching the end of their egg-laying cycles, being a major byproduct of the egg industry. Recent studies have been focusing on finding new value-added uses for spent hens. We have previously identified four b…
View article: Developing Antihypertensive Peptides from Spent Laying Hen Muscle Proteins
Developing Antihypertensive Peptides from Spent Laying Hen Muscle Proteins Open
Hypertension is the leading cause of global morbidity and mortality, afflicting > 20% of adults worldwide (~1 in 4 in Canada). Pharmaceutical drugs are the primary treatment for hypertension, but are generally associated with side effects.…
View article: Spent Hen Protein Hydrolysate with Good Gastrointestinal Stability and Permeability in Caco-2 Cells Shows Antihypertensive Activity in SHR
Spent Hen Protein Hydrolysate with Good Gastrointestinal Stability and Permeability in Caco-2 Cells Shows Antihypertensive Activity in SHR Open
Spent hens are a major byproduct of the egg industry but are rich in muscle proteins that can be enzymatically transformed into bioactive peptides. The present study aimed to develop a spent hen muscle protein hydrolysate (SPH) with antihy…
View article: Identification of angiotensin converting enzyme 2 (ACE2) up-regulating peptides from pea protein hydrolysate
Identification of angiotensin converting enzyme 2 (ACE2) up-regulating peptides from pea protein hydrolysate Open
View article: Egg White–Derived Antihypertensive Peptide IRW (Ile‐Arg‐Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1‐7)/Mas Receptor Axis
Egg White–Derived Antihypertensive Peptide IRW (Ile‐Arg‐Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1‐7)/Mas Receptor Axis Open
Scope It is found in the previous study that egg‐white‐derived antihypertensive peptide Ile‐Arg‐Trp (IRW) upregulated angiotensin converting enzyme 2 (ACE2) in spontaneously hypertensive rats (SHRs). The objective of this study is to evalu…