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View article: Case Report: Primary pulmonary lymphoma with CT negative and PET high metabolism combined with hemophagocytic syndrome
Case Report: Primary pulmonary lymphoma with CT negative and PET high metabolism combined with hemophagocytic syndrome Open
Background Primary pulmonary diffuse large B-cell lymphoma (DLBCL) is usually accompanied by imaging visible lesions. Cases with normal CT morphology and high PET metabolism are extremely rare, especially when combined with hemophagocytic …
View article: Five-year follow-up retrospective review of colorectal cancer patients in Johor Bahru
Five-year follow-up retrospective review of colorectal cancer patients in Johor Bahru Open
Purpose Data on colorectal cancer in Malaysia, particularly from southern regions such as Johor Bahru is underreported. To address this gap, we conducted a retrospective review of colorectal cancer patients treated in Johor Bahru 5 years a…
View article: [Efficacy and safety of venetoclax combined with tyrosine kinase inhibitors and reduced-dose chemotherapy in 13 cases of minimal residual disease-positive and relapsed/refractory Ph(+) acute lymphoblastic leukemia].
[Efficacy and safety of venetoclax combined with tyrosine kinase inhibitors and reduced-dose chemotherapy in 13 cases of minimal residual disease-positive and relapsed/refractory Ph(+) acute lymphoblastic leukemia]. Open
This study sought to evaluate the efficacy and safety of venetoclax (Ven) in combination with tyrosine kinase inhibitors (TKI) and reduced-dose chemotherapy for the treatment of patients with minimal residual disease (MRD) -positive and re…
View article: An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism
An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism Open
View article: Dietary and Lifestyle Strategies for Endometrial Cancer Prevention: Emerging Evidence and Unanswered Questions
Dietary and Lifestyle Strategies for Endometrial Cancer Prevention: Emerging Evidence and Unanswered Questions Open
View article: Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)
Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review) Open
Circular RNAs (circRNAs) have emerged as promising biomarkers and therapeutic targets in gynecological cancer. The present review explored developments in circRNA research in ovarian, endometrial and cervical cancer. circRNA biogenesis, fu…
View article: Exploring the Current State and Research Innovation in Endometrial Cancer Screening
Exploring the Current State and Research Innovation in Endometrial Cancer Screening Open
View article: Advances in auxin synthesis, transport, and signaling in rice: implications for stress resilience and crop improvement
Advances in auxin synthesis, transport, and signaling in rice: implications for stress resilience and crop improvement Open
Auxin, a crucial plant hormone, plays a pivotal role in regulating various aspects of rice growth and development, including cell elongation, root formation, and responses to environmental stimuli. Recent breakthroughs in auxin research ha…
View article: Current research update on group B streptococcal infection related to obstetrics and gynecology
Current research update on group B streptococcal infection related to obstetrics and gynecology Open
Group B streptococcal (GBS) is a Gram-positive bacterium that is commonly found in the gastrointestinal tract and urogenital tract. GBS infestation during pregnancy is a significant contributor to maternal and neonatal morbidity and mortal…
View article: Recent development of oral vaccines (Review)
Recent development of oral vaccines (Review) Open
Oral immunization can elicit an effective immune response and immune tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via the gastrointestinal mucosa offers superior immune effects and…
View article: [Retrospective analysis of the efficacy and safety of Venetoclax-based regimen in the treatment of 12 cases of acute myeloid leukemia with t (8; 21)].
[Retrospective analysis of the efficacy and safety of Venetoclax-based regimen in the treatment of 12 cases of acute myeloid leukemia with t (8; 21)]. Open
View article: [The clinical safety and efficacy of the patients of acute myeloid leukemia with FLT3-ITD positive treated with sorafenib in combination with venetoclax and azactitidine regimen].
[The clinical safety and efficacy of the patients of acute myeloid leukemia with FLT3-ITD positive treated with sorafenib in combination with venetoclax and azactitidine regimen]. Open
View article: Obstructive Sleep Apnea Detection Based on Sleep Sounds via Deep Learning
Obstructive Sleep Apnea Detection Based on Sleep Sounds via Deep Learning Open
Our results showed that a deep learning algorithm based on sleep sounds recorded by a noncontact voice recorder served as a feasible tool for apneic event detection and OSA identification. This technique may hold promise for OSA assessment…
View article: Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia
Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia Open
T cell immune dysfunction is a prominent characteristic of chronic lymphocytic leukemia (CLL) and the main cause of failure for immunotherapy and multi-drug resistance. There remains a lack of specific biomarkers for evaluating T cell immu…
View article: Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s Open
Gartanin, a compound found in mangosteen, has various pharmacological activities, including anticancer, anti-inflammation, and antioxidation.In the present study, we reported differences of gartanin metabolism among species and the effect …
View article: Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology
Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology Open
Based on the research methods of network pharmacology, this study analyzed the improvement effect of berberine (BBR) on premature ovarian failure (POF) and its molecular mechanism. Carry out GO and KEGG enrichment analysis by R language to…
View article: The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemia
The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemia Open
The prognostic effects of the CD20 positivity have been studied extensively in B‐lineage acute lymphocyte leukemia (B‐ALL) patients, but the results remain controversial. The aim of this study is to investigate the different predictive eff…
View article: Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology
Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology Open
Based on the research methods of network pharmacology, this study analyzed the improvement effect of berberine (BBR) on premature ovarian failure (POF) and its molecular mechanism. Carry out GO and KEGG enrichment analysis by R language to…
View article: Is it reasonable to use existing outside soil spray seeding technology to prepare artificial soil under slope aspect and landslide in alpine area？
Is it reasonable to use existing outside soil spray seeding technology to prepare artificial soil under slope aspect and landslide in alpine area？ Open
Knowledge about artificial soil nutrient of cut-slopes associated with slope aspect and landslide attributes is vital for understanding cut-slopes environmental ecosystem and establishing sustainable artificial soil management practices. O…
View article: Gain-of-Function NH787 Ethylmethanesulfonate Mutant of Nagina22 Rice Variety Confers Augmented PUE
Gain-of-Function NH787 Ethylmethanesulfonate Mutant of Nagina22 Rice Variety Confers Augmented PUE Open
Rice ( Oryza sativa L.), a major dietary source, is often cultivated in soils poor in available inorganic orthophosphate (Pi), which is a pivotal nutrient for growth and development. Poor soils are amended by phosphorus (P) fertilizer, whi…
View article: The Predictive Value of the Peripheral Blood Lymphocyte-to-Monocyte Ratio in Patients with Anaplastic Large Cell Lymphoma
The Predictive Value of the Peripheral Blood Lymphocyte-to-Monocyte Ratio in Patients with Anaplastic Large Cell Lymphoma Open
Background To assess the value of the peripheral blood lymphocyte-to-monocyte ratio (LMR) in predicting the early treatment response and prognosis in patients with anaplastic large cell lymphoma (ALCL). Methods The optimal cut-off value fo…
View article: [Combination of interferon alpha-1b, interleukin-2 and thalidomide as maintenance therapy on acute myeloid leukemia patients with negative minimal residual disease].
[Combination of interferon alpha-1b, interleukin-2 and thalidomide as maintenance therapy on acute myeloid leukemia patients with negative minimal residual disease]. Open
View article: Whether CAR-T cell bridging to allo-HSCT increases the incidence of graft-versus-host disease in patients with high-risk chronic lymphocytic leukemia
Whether CAR-T cell bridging to allo-HSCT increases the incidence of graft-versus-host disease in patients with high-risk chronic lymphocytic leukemia Open
Background The TP53 aberration[both del(17p) and TP53 mutations], a high-risk prognostic factor in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), is closely related to drug-resistance, rapid disease prog…
View article: [Safety and efficacy of patients with refractory B-lymphoblastic leukemia treated with anti-CD19 CAR-T cell bridging to allogeneic hematopoietic stem cell transplantation].
[Safety and efficacy of patients with refractory B-lymphoblastic leukemia treated with anti-CD19 CAR-T cell bridging to allogeneic hematopoietic stem cell transplantation]. Open
Objective: To investigate the efficacy and side effects of anti-CD19 CAR-T cell bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT) regimen for refractory B-lymphoblastic leukemia. Methods: 10 patients …
View article: [MicroRNA-145-5p over-expression suppresses proliferation, migration and invasion and promotes apoptosis of human endometrial cancer cells by targeting dual specific phosphatase 6].
[MicroRNA-145-5p over-expression suppresses proliferation, migration and invasion and promotes apoptosis of human endometrial cancer cells by targeting dual specific phosphatase 6]. Open
Overexpression of miR-145-5p inhibits the proliferation, migration and invasion and promotes apoptosis of endometrial cancer cells possibly by negative regulation of DUSP6 expression.
View article: [Clinical observation of 12 patients with refractory/relapsed acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation containing cladribine regimen].
[Clinical observation of 12 patients with refractory/relapsed acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation containing cladribine regimen]. Open
Objective: To investigate the safety and efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) containing cladribine sequential busulfan regimen for refractory/relapsed acute myeloid leukemia (AML) . Methods:…
View article: [Fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation].
[Fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation]. Open
OBJECTIVE: To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Four acute leukemia patients suffere…
View article: Combined inhibition of FGFR and mTOR pathways is effective in suppressing ovarian cancer.
Combined inhibition of FGFR and mTOR pathways is effective in suppressing ovarian cancer. Open
The PI3K/AKT/mTOR signaling pathway is considered as a promising therapeutic target in the treatment of ovarian cancer (OC); however, inhibition of this pathway only exhibited moderate clinical efficacy when tested clinically. Combination …
View article: [The expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia and its prognostic significance].
[The expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia and its prognostic significance]. Open
Objective: To detect the expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia (B-ALL) in newly diagnosed cases, and to investigate the relationship between CRLF2 and the general clinical characteristics, efficacy an…
View article: A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome
A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome Open