Hongchuan Zhao
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View article: Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the <i>mAAP</i> gene in silkworm and its role in antiviral defense against BmCPV
Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the <i>mAAP</i> gene in silkworm and its role in antiviral defense against BmCPV Open
A novel circular RNA, circRNA_1193, which originates from the membrane alanyl aminopeptidase-like gene in silkworms, was explored for its potential function and regulatory mechanism. We validated the presence of circRNA_1193 in Bombyx mori…
View article: Aging‐Associated Liver Sinusoidal Endothelial Cells Dysfunction Aggravates the Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease
Aging‐Associated Liver Sinusoidal Endothelial Cells Dysfunction Aggravates the Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Aging increases the susceptibility to metabolic dysfunction–associated steatotic liver disease (MASLD). Liver sinusoidal endothelial cells (LSECs) help in maintaining hepatic homeostasis, but the contribution of age‐associated LSECs dysfun…
View article: Preoperative Serum Glycan Levels Reflect Progression of Patients With Hepatocellular Carcinoma
Preoperative Serum Glycan Levels Reflect Progression of Patients With Hepatocellular Carcinoma Open
Background Abnormal glycosylation is associated with tumors. The clinical value of serum glycans in assessing progression of hepatocellular carcinoma (HCC) patients remains a challenge. Methods A study dynamically comparing levels of fifte…
View article: Corrosion and tensile testing study of high temperature and high pressure well injection and production integrated string
Corrosion and tensile testing study of high temperature and high pressure well injection and production integrated string Open
In this study, corrosion experiments were conducted on three commonly used materials for integrated strings (L80, 2205, P110) using the hanging strip corrosion method at high temperature and high pressure. Subsequently, high temperature te…
View article: Numerical simulation study on the mechanical characteristics of downhole heat fluid generators in heavy oil thermal recovery wells
Numerical simulation study on the mechanical characteristics of downhole heat fluid generators in heavy oil thermal recovery wells Open
In this study, we conducted temperature, pressure, and stress deformation calculations for the tubing of a specific heavy oil thermal recovery well. Subsequently, we used the axial force on the tubing at the depth of the thermal fluid gene…
View article: Construction and validation of a immune-related prognostic gene DHRS1 in hepatocellular carcinoma based on bioinformatic analysis
Construction and validation of a immune-related prognostic gene DHRS1 in hepatocellular carcinoma based on bioinformatic analysis Open
A member of the short-chain dehydrogenase/reductase superfamily (DHRS1, SDR19C1) is a member of the short-chain dehydrogenase/reductase superfamily and a potential predictor of hepatocellular carcinoma (HCC). However, the role of DHRS1 in …
View article: Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma
Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma Open
Let-7c-5p has been proved to suppress HCC by down-regulating immune-related CDCA8, which will help understand the pathogenesis of HCC and develop drugs for its treatment.
View article: High level of tumor marker CA19-9 returned to normal after cholecystectomy in calculous cholecystitis patients
High level of tumor marker CA19-9 returned to normal after cholecystectomy in calculous cholecystitis patients Open
Serum CA19-9 is proved to be associated with calculous cholecystitis for the first time, so that clinicians should consider calculous cholecystitis associated CA19-9 elevation in the clinic practice besides other CA19-9 related diseases.
View article: Application of RNA processing factors for predicting clinical outcomes in colon cancer
Application of RNA processing factors for predicting clinical outcomes in colon cancer Open
Background: Colon cancer is the fifth most common cause of cancer-related death worldwide, and despite significant advances in related treatment, the prognosis of colon cancer patients remains poor. Objective: This study performs systemati…
View article: Liver Transplantation in Acute-on-Chronic Liver Failure: Excellent Outcome and Difficult Posttransplant Course
Liver Transplantation in Acute-on-Chronic Liver Failure: Excellent Outcome and Difficult Posttransplant Course Open
Background Acute-on-chronic liver failure (ACLF) patients have high mortality in a short period of time. This study aimed to compare the prognosis of transplanted ACLF patients to that of nontransplanted ACLF patients and decompensated cir…
View article: Recent Advances in Liver Engineering With Decellularized Scaffold
Recent Advances in Liver Engineering With Decellularized Scaffold Open
Liver transplantation is currently the only effective treatment for patients with end-stage liver disease; however, donor liver scarcity is a notable concern. As a result, extensive endeavors have been made to diversify the source of donor…
View article: Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling
Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling Open
The long noncoding RNA growth-arrest specific 5 (GAS5) is a suppressor of many cancers. However, the role and mechanism of action of GAS5 in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain unclear. Here, the expressio…
View article: Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma
Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma Open
Objective Altered metabolites are important for the tumourigenicity of hepatocellular carcinoma (HCC). We performed integrative metabolomics analysis of the metabolites changes in portal venous blood and in comparison with the metabolites …
View article: Propensity score matching study of 325 patients with spontaneous rupture of hepatocellular carcinoma
Propensity score matching study of 325 patients with spontaneous rupture of hepatocellular carcinoma Open
BACKGROUND: This study aims to find out the possible optimal therapy and assess the prognosis properly for patient with spontaneous rupture of hepatocellular carcinoma (HCC). METHODS: Propensity score matching (PSM) analysis was used to st…
View article: Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis
Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis Open
Objectives: Serum biomarkers are valuable for clinical decision-making for patients with hepatocellular carcinoma (HCC), among which the most promising are AFP, AFP-L3, DCP, DKK-1, and GP73; however, the efficacy of using combined biomarke…
View article: Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis
Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis Open
Objectives: Serum biomarkers are valuable for clinical decision-making for patients with hepatocellular carcinoma (HCC), among which the most promising are AFP, AFP-L3, DCP, DKK-1, and GP73; however, the efficacy of using combined biomarke…
View article: Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product
Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product Open
There is great interest in developing small molecules agents capable of reversing tumor immune escape to restore the body’s immune system. As an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO-1) is considered a promising targ…
View article: Using a Commonly Down-Regulated Cytomegalovirus (CMV) Promoter for High-Level Expression of Ectopic Gene in a Human B Lymphoma Cell Line
Using a Commonly Down-Regulated Cytomegalovirus (CMV) Promoter for High-Level Expression of Ectopic Gene in a Human B Lymphoma Cell Line Open
BACKGROUND Vectors are widely used to drive gene expression using a promoter. However, not all promoters are able to drive ectopic gene expression efficiently, including CMV promoter. Here, we report our data using CMV promoter for high-le…
View article: BiClamp® vessel-sealing device for open hepatic resection of malignant and benign liver tumours: a single-institution experience
BiClamp® vessel-sealing device for open hepatic resection of malignant and benign liver tumours: a single-institution experience Open
This trial was retrospectively registered and the detail information was as followed. Registration number: ChiCTR-ORC-17011873 (Chinese Clinical Trial Registry). Registration Date: 2017-07-05.
View article: One-layer versus two-layer duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy: study protocol for a randomized controlled trial
One-layer versus two-layer duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy: study protocol for a randomized controlled trial Open
Clinical Trials.gov: NCT02511951 . Registered on 29 July 2015.