ABSTRACT Aging increases the susceptibility to metabolic dysfunction–associated steatotic liver disease (MASLD). Liver sinusoidal endothelial cells (LSECs) help in maintaining hepatic homeostasis, but the contribution of age‐associated LSECs dysfunction to MASLD is not clear. The aim of this study was to investigate the effect of aging‐associated LSECs dysfunction on MASLD. Free fatty acid–treated AML12 cells were co‐cultured with young and etoposide‐induced senescent TSEC cells to evaluate the senescence‐associat…

ABSTRACT A novel circular RNA, circRNA_1193, which originates from the membrane alanyl aminopeptidase-like gene in silkworms, was explored for its potential function and regulatory mechanism. We validated the presence of circRNA_1193 in Bombyx mori cytoplasmic polyhedrosis virus (BmCPV)-infected silkworm ovary cell line (BmN) cells through a combination of reverse transcription polymerase chain reaction, Northern blotting, and in situ hybridization. CircRNA_1193 exhibited tissue-specific expression, being highly e…

ABSTRACT Background Abnormal glycosylation is associated with tumors. The clinical value of serum glycans in assessing progression of hepatocellular carcinoma (HCC) patients remains a challenge. Methods A study dynamically comparing levels of fifteen lectin‐specific glycans between preoperative and postoperative serum of 65 HCC patients was conducted via lectin biochip technology. Multivariable logistic regression analysis was used to address associations between serum glycan levels and clinicopathological charact…

In this study, we conducted temperature, pressure, and stress deformation calculations for the tubing of a specific heavy oil thermal recovery well. Subsequently, we used the axial force on the tubing at the depth of the thermal fluid generator as a boundary condition and incorporated it into numerical simulation software to analyze the thermo-fluid-solid coupled mechanical characteristics of the generator under these operating conditions. Our findings indicate that the cooling water within the generator effective…

In this study, corrosion experiments were conducted on three commonly used materials for integrated strings (L80, 2205, P110) using the hanging strip corrosion method at high temperature and high pressure. Subsequently, high temperature tensile tests were performed on the three materials, and the variations in parameters such as corrosion rate, yield strength, and tensile strength under different experimental temperatures were compared and analyzed. The experimental results indicate that with increasing experiment…