Honggui Yu
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View article: Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition
Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition Open
Naringenin (NAR), a natural flavonoid, exerts anti-inflammatory and antioxidant pharmacology. However, the pharmacological mechanisms through which NAR prevents and treats intervertebral disc degeneration (IDD) remain unclear. We utilized …
View article: Ferrostatin-1 facilitated neurological functional rehabilitation of spinal cord injury mice by inhibiting ferroptosis
Ferrostatin-1 facilitated neurological functional rehabilitation of spinal cord injury mice by inhibiting ferroptosis Open
View article: Ferrostatin-1 facilitated neurological functional rehabilitation of spinal cord injury mice by inhibiting ferroptosis
Ferrostatin-1 facilitated neurological functional rehabilitation of spinal cord injury mice by inhibiting ferroptosis Open
Background To seek the potential therapy for spinal cord injury, Ferrostatin-1, the first ferroptosis inhibitor, was indicated in spinal cord injury mice, to identify the therapeutic effect. (2)Methods: spinal cord injury model was establi…
View article: Posterior Approach With Osteotomized Debridement Versus Combined Anterior and Posterior Approach in Treating Thoracolumbar Tuberculosis: A Retrospective Cohort Study
Posterior Approach With Osteotomized Debridement Versus Combined Anterior and Posterior Approach in Treating Thoracolumbar Tuberculosis: A Retrospective Cohort Study Open
Study Design Retrospective cohort. Objectives To compare outcomes of posterior osteotomized debridement (OD) with combined anterior and posterior approach (AP) in treating thoracolumbar tuberculosis (TB). Methods This study reviewed 178 pa…
View article: Bone marrow mesenchymal stem cell-derived exosomal LINC00847 inhibits the proliferation, migration, and invasion of Ewing sarcoma
Bone marrow mesenchymal stem cell-derived exosomal LINC00847 inhibits the proliferation, migration, and invasion of Ewing sarcoma Open
These findings suggest that BMSCs-derived exosomal lncRNAs may be used for the personalized treatment of tumors, providing a novel theoretical framework for treating ES.
View article: Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28
Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28 Open
Cancer stem cells (CSCs) have been documented to be closely related with tumor metastasis and recurrence, and the same important role were identified in Ewing Sarcoma (ES). In our previous study, we found that let-7a expression was repress…
View article: LncRNA FOXP4-AS1 Promotes Progression of Ewing Sarcoma and Is Associated With Immune Infiltrates
LncRNA FOXP4-AS1 Promotes Progression of Ewing Sarcoma and Is Associated With Immune Infiltrates Open
Ewing sarcoma (ES) is a highly malignant primary bone tumor with poor prognosis. Studies have shown that abnormal expression of lncRNA influences the prognosis of tumor patients. Herein, we established that FOXP4-AS1 was up-regulated in ES…
View article: Let-7a Suppresses Ewing Sarcoma CSCs’ Malignant Phenotype via Forming a Positive Feedback Circuit with STAT3 and lin28
Let-7a Suppresses Ewing Sarcoma CSCs’ Malignant Phenotype via Forming a Positive Feedback Circuit with STAT3 and lin28 Open
BackgroundCancer stem cells (CSCs) have been documented to be closely related with tumor metastasis and recurrence, and the same important role were identified in Ewing Sarcoma (ES). In our previous study, we found that let-7a was represse…
View article: Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28
Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28 Open
Background：Cancer stem cells (CSCs) have been documented to be closely related with tumor metastasis and recurrence, and the same important role were identified in Ewing Sarcoma (ES). In our previous study, we found that let-7a was repress…
View article: The three-dimensional printed template guided technique for S2 alar iliac screw placement and a comparison with freehand technique
The three-dimensional printed template guided technique for S2 alar iliac screw placement and a comparison with freehand technique Open
Purpose: Sacropelvic fixation continues to present challenges when involved in the adult spinal deformity correction. The S2 alar iliac (S2AI) fixation is commonly used in sacropelvic fixation. Several techniques, including intraoperative …
View article: The three-dimensional printed template guided technique for S2AI screw placement and a comparison with freehand technique
The three-dimensional printed template guided technique for S2AI screw placement and a comparison with freehand technique Open
Background Sacropelvic fixation continues to present challenges when involved in the adult spinal deformity correction. The S2 alar iliac (S2AI) fixation is commonly used in sacropelvic fixation. Several techniques, including intraoperativ…
View article: A comparative study of laminoplasty with short segment transpedicular screw fixation versus laminoplasty with anterior fusion in treating extensional cervical spinal cord injury without radio graphic abnormality in adults
A comparative study of laminoplasty with short segment transpedicular screw fixation versus laminoplasty with anterior fusion in treating extensional cervical spinal cord injury without radio graphic abnormality in adults Open
Background: Cervical spinal cord injury(CSCI) without major fracture or dislocation is often described as cervical SCI without radiographic abnormality (SCIWORA). Majority of this injury could be without radiographic abnormality but with d…
View article: MicroRNA‑30a regulates chondrogenic differentiation of human bone marrow‑derived mesenchymal stem cells through targeting Sox9
MicroRNA‑30a regulates chondrogenic differentiation of human bone marrow‑derived mesenchymal stem cells through targeting Sox9 Open
Cartilage injury is difficult to repair since the cartilage tissue lacks self-restoration ability. Improved formation of chondrocytes differentiated from the mesenchymal stem cells (MSC) by genetic regulation is a potentially promising the…