Honghai Tang
YOU?
Author Swipe
View article: Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness
Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness Open
View article: PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation
PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation Open
Hearing loss is one of the most prevalent sensory disorders, but no commercial biological treatments are currently available. Here, we identify an East Asia-specific founder mutation, the homozygous c.220 C > T mutation in MPZL2, that cont…
View article: PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation
PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation Open
Hearing loss is one of the most prevalent sensory disorders, but no commercial biological treatments are currently available. Here, we identified an East Asia-specific founder mutation, the homozygous c.220C>T mutation in MPZL2, that contr…
View article: PAM-flexible adenine base editing rescues hearing loss in a humanized<i>MPZL2</i>mouse model harboring an East Asian founder mutation
PAM-flexible adenine base editing rescues hearing loss in a humanized<i>MPZL2</i>mouse model harboring an East Asian founder mutation Open
Hearing loss is one of the most prevalent sensory disorders, but no commercial biological treatments are currently available. Here, we identified an East Asia-specific founder mutation, the homozygous c.220C>T mutation in MPZL2 , that cont…
View article: Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results Open
View article: Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model
Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model Open
View article: Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear
Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear Open
Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should furth…
View article: Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primates Open
Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss 9 (DFNB9), one of the most common forms of auditory neuropathy. There is no biological treatment for DFNB9. Here, we designed an OTOF gene therapy agent by dual A…
View article: Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants
Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants Open
View article: Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice
Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice Open
CasRx, a recently discovered member of the type VI CRISPR system with minimum size, offers a new approach for RNA manipulation with high efficiency and specificity in prokaryotes and eukaryotes. However, in vivo studies of functiona…
View article: Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing Open
View article: Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State
Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State Open
CRISPR-Cas9 is a powerful tool for target genome editing in living cells. Significant advances have been made to understand how this system cleaves target DNA. However, due to difficulty in determining active CRISPR-Cas9 structure in DNA c…