Honghao Li
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View article: Castleman disease coexisting with papillary thyroid carcinoma: A case report
Castleman disease coexisting with papillary thyroid carcinoma: A case report Open
Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology characterized by lymph node enlargement. CD cannot be confirmed by preoperative puncture cytology, and definitive diagnosis depends on postoperative histopat…
View article: <i>Lactobacillus kefiranofaciens</i> and <i>Lactobacillus kefiri</i> are the key species in kefir for reversing oxytetracycline-induced intestinal damage in zebrafish
<i>Lactobacillus kefiranofaciens</i> and <i>Lactobacillus kefiri</i> are the key species in kefir for reversing oxytetracycline-induced intestinal damage in zebrafish Open
Increased accumulation of oxytetracycline (OTC) in environmental water bodies could potentially lead to its accumulation in human body, thereby damaging human intestinal tract. Dietary interventions could be helpful for recovery of intesti…
View article: iNP_ESM: Neuropeptide Identification Based on Evolutionary Scale Modeling and Unified Representation Embedding Features
iNP_ESM: Neuropeptide Identification Based on Evolutionary Scale Modeling and Unified Representation Embedding Features Open
Neuropeptides are biomolecules with crucial physiological functions. Accurate identification of neuropeptides is essential for understanding nervous system regulatory mechanisms. However, traditional analysis methods are expensive and labo…
View article: Mechanism of activation of β-1,3-glucan synthase by Rho1
Mechanism of activation of β-1,3-glucan synthase by Rho1 Open
The β-1,3 glucan synthase (GS) is essential for the biosynthesis of β-1,3 glucan, a well-conserved structural component of fungal cell wall. The GS holoenzyme is a multi-enzyme complex consisting of the glycosyltransferase FKS and the esse…
View article: Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast
Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast Open
Natural sugar substitutes are safe, stable, and nearly calorie-free. Thus, they are gradually replacing the traditional high-calorie and artificial sweeteners in the food industry. Currently, the majority of natural sugar substitutes are e…
View article: More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study
More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study Open
Adjustment for prognostic covariates increases the statistical power of randomized trials. The factors influencing the increase of power are well-known for trials with continuous outcomes. Here, we study which factors influence power and s…
View article: Engineering ligand stabilized aquaporin reporters for magnetic resonance imaging
Engineering ligand stabilized aquaporin reporters for magnetic resonance imaging Open
Imaging transgene expression in live tissues requires reporters that are detectable with deeply penetrant modalities, such as magnetic resonance imaging (MRI). Here, we show that LSAqp1, a water channel engineered from aquaporin-1, can be …
View article: Stratification of ovarian cancer patients from the prospect of drug target-related transcription factor protein activity: the prognostic and genomic landscape analyses
Stratification of ovarian cancer patients from the prospect of drug target-related transcription factor protein activity: the prognostic and genomic landscape analyses Open
The expression and activity of transcription factors, which directly mediate gene transcription, are strictly regulated to control numerous normal cellular processes. In cancer, transcription factor activity is often dysregulated, resultin…
View article: Effects of specific doses of E-beam irradiation which inactivated SARS-CoV-2 on the nutrition and quality of Atlantic salmon
Effects of specific doses of E-beam irradiation which inactivated SARS-CoV-2 on the nutrition and quality of Atlantic salmon Open
The contamination of Atlantic salmon with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impeded the development of the cold-chain food industry and posed possible risks to the population. Electron beam (E-beam) irradiati…
View article: Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and Phytophthora infestans
Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and Phytophthora infestans Open
Late blight is one of the main biological stresses limiting the potato yield; however, the biochemical mechanisms underlying the infection process of Phytophthora infestans remain unrevealed. In this study, the late blight-resistant potato…
View article: Dual RNA Sequencing Reveals the Genome-Wide Expression Profiles During the Compatible and Incompatible Interactions Between Solanum tuberosum and Phytophthora infestans
Dual RNA Sequencing Reveals the Genome-Wide Expression Profiles During the Compatible and Incompatible Interactions Between Solanum tuberosum and Phytophthora infestans Open
Late blight, caused by Phytophthora infestans ( P. infestans ), is a devastating plant disease. P. infestans genome encodes hundreds of effectors, complicating the interaction between the pathogen and its host and making it difficult to un…
View article: Adult Onset Alexander Disease Presenting as Psychogenic Polydipsia Induced Recurrent Hyponatremia as the Initial Symptom: A Case Report.
Adult Onset Alexander Disease Presenting as Psychogenic Polydipsia Induced Recurrent Hyponatremia as the Initial Symptom: A Case Report. Open
BackgroundAlexander disease (AxD, OMIM 203450) is a rare and generally fatal disorder of the central nervous system associated with heterozygous mutations in glial fibrillary acidic protein (GFAP) gene. Neuroradiological and clinical featu…
View article: Sex Differences In The Association Between Hemoglobin A1c And Cerebral White Matter Lesions In The General Japanese Population
Sex Differences In The Association Between Hemoglobin A1c And Cerebral White Matter Lesions In The General Japanese Population Open
The influence of diabetes and associated sex differences on cerebral white matter lesions (WMLs) is unclear. We used data from a cross-sectional study uploaded to the DATADRYAD website by Shinkawa et al. to investigate differences in the a…
View article: β-catenin/LEF-1 Transcription Complex is Responsible for the Transcriptional Activation of LINC01278
β-catenin/LEF-1 Transcription Complex is Responsible for the Transcriptional Activation of LINC01278 Open
Background: Our previous study shows that LINC01278 inhibits the development of papillary thyroid carcinoma (PTC) by regulating miR-376c-3p/DNM3 axis. However, the regulation mechanism of LINC01278 expression in PTC cells is still unclear.…
View article: Lysine-Specific Demethylase 1 Affects the Progression of Papillary Thyroid Carcinoma via HIF1α and microRNA-146a
Lysine-Specific Demethylase 1 Affects the Progression of Papillary Thyroid Carcinoma via HIF1α and microRNA-146a Open
Context Lysine-specific demethylase 1 (LSD1) stabilizes hypoxia-inducible factor 1α (HIF1α) to advance tumor progression, while HIF1α functions as a transcription factor to increase the expression of microRNA-146a (miR-146a). Objective We …
View article: Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma.
Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma. Open
The circRNA hsa_circ_0007694 is down-regulated in PTC and is therefore a potential therapeutic target.
View article: Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition)
Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition) Open
As a treatment option for cancer, thermal ablation has satisfactory effects on many types of solid tumors (such as liver and renal cancers). However, its clinical applications for the treatment of thyroid nodules and metastatic cervical ly…
View article: Long non‐coding RNA TNRC6C‐AS1 promotes methylation of STK4 to inhibit thyroid carcinoma cell apoptosis and autophagy via Hippo signalling pathway
Long non‐coding RNA TNRC6C‐AS1 promotes methylation of STK4 to inhibit thyroid carcinoma cell apoptosis and autophagy via Hippo signalling pathway Open
The role of long non‐coding RNAs (lncRNAs) in thyroid carcinoma (TC), the most frequent endocrine malignancy, has been extensively examined. This study investigated effect of interaction among lncRNA TNRC6C‐AS1, serine/threonine‐protein ki…
View article: Electrostatic shape control of a charged molecular membrane from ribbon to scroll
Electrostatic shape control of a charged molecular membrane from ribbon to scroll Open
Bilayers of amphiphiles can organize into spherical vesicles, nanotubes, planar, undulating, and helical nanoribbons, and scroll-like cochleates. These bilayer-related architectures interconvert under suitable conditions. Here, a charged, …
View article: <p>Linc01278 inhibits the development of papillary thyroid carcinoma by regulating miR-376c-3p/DNM3 axis</p>
Linc01278 inhibits the development of papillary thyroid carcinoma by regulating miR-376c-3p/DNM3 axis Open
Overall, we found that linc01278 can act as a competing endogenous RNA (ceRNA) to sponge miR-376c-3p, thereby positively regulating DNM3 expression and ultimately acting as a tumor suppressor gene in PTC progression.
View article: Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma
Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma Open
Papillary thyroid carcinoma (PTC) is a type of cancer with one of the fastest increasing incidences worldwide. However, the therapeutic choices for PTC patients are limited and it is critical to further understand the molecular pathology u…
View article: MicroRNA-125b Affects Vascular Smooth Muscle Cell Function by Targeting Serum Response Factor
MicroRNA-125b Affects Vascular Smooth Muscle Cell Function by Targeting Serum Response Factor Open
Background/Aims: Increasing evidence links microRNAs to the pathogenesis of peripheral vascular disease. We recently found microRNA-125b (miR-125b) to be one of the most significantly down‑regulated microRNAs in human arteries with arterio…
View article: Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma
Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma Open
Rho-associated protein kinase 1 (ROCK1), a serine/threonine kinase, has previously been shown to be over-expressed in various types of human malignant tumors and to play an important role in cancer development and progression. Although ROC…