Honghong Liu
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View article: Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment
Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment Open
View article: IL-4R+SELL+ Naïve B Cell Expansion correlates with functional cure in PEG-IFNα Treated Chronic Hepatitis B Patients
IL-4R+SELL+ Naïve B Cell Expansion correlates with functional cure in PEG-IFNα Treated Chronic Hepatitis B Patients Open
During chronic hepatitis B (CHB) infection, B cell dysfunction is a key contributor to viral persistence. Pegylated interferon alpha (PEG-IFNα) acts as an effective therapeutic agent for CHB by restoring immune responses directed against H…
View article: Safety and efficacy of 177Lu-FAPI-XT radioligand therapy in patients with advanced sarcoma and other cancer entities: first-in-human, dose-escalation study
Safety and efficacy of 177Lu-FAPI-XT radioligand therapy in patients with advanced sarcoma and other cancer entities: first-in-human, dose-escalation study Open
PURPOSE: This phase I, first-in-human study evaluated the safety, dosimetry, and preliminary efficacy of 177Lu-FAPI-XT, a novel fibroblast activation protein (FAP)-targeted radioligand, in patients with advanced solid tumors r…
View article: Low‐Grade Fetal Adenocarcinoma of the Lung on <scp> <sup>18</sup> F </scp> ‐ <scp>FDG PET</scp> / <scp>CT</scp>
Low‐Grade Fetal Adenocarcinoma of the Lung on <span> <sup>18</sup> F </span> ‐ <span>FDG PET</span> / <span>CT</span> Open
Fetal adenocarcinoma of the lung (FLAC) is extremely rare without specific common symptoms and is difficult to distinguish from other lung cancers just by clinical symptoms and traditional imaging. We reported a case of FLAC that underwent…
View article: Correction to: Non-invasive remote ischemic postconditioning stimulates neurogenesis during the recovery phase after cerebral ischemia
Correction to: Non-invasive remote ischemic postconditioning stimulates neurogenesis during the recovery phase after cerebral ischemia Open
View article: Incompatibility of Model Specifications in GLMs: A Response to the Misclaim of Neuhaus and Jewell (2025)
Incompatibility of Model Specifications in GLMs: A Response to the Misclaim of Neuhaus and Jewell (2025) Open
Summary In our paper (Feng et al., 2024), we identified a critical flaw in the work of Neuhaus and Jewell (1993). Although Neuhaus and Jewell (2025) argue that we misinterpreted their results, we respectfully disagree. In this paper, we pr…
View article: Inconsistency between conditional and marginal analyses
Inconsistency between conditional and marginal analyses Open
Conditional and marginal analyses are widely used in clinical studies. However, the results of these two methods may occasionally contradict each other. For instance, marginal analysis may show that the treatment group outperforms the cont…
View article: Incompatibility of Model Specifications in Generalized Linear Models
Incompatibility of Model Specifications in Generalized Linear Models Open
Summary The choice of regression models can vary depending on a study’s objectives and the characteristics of the dataset. Yet it is crucial to recognize that the properties of conditional expectation impose a natural consistency requireme…
View article: Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis
Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis Open
Our study revealed that ZJP treats CAG by inhibiting the PI3K/Akt signaling pathway. This research provided a scientific basis for the rational use of ZJP in clinical practice.
View article: Feasibility analysis of digital method for measuring supracrestal tissue height crest around implant.
Feasibility analysis of digital method for measuring supracrestal tissue height crest around implant. Open
The digital me-thod is in good agreement with the periodontal probe method in measuring the soft tissue height of the bone cristae around the implant.
View article: Analysis of the Nursing Effect of Anesthesia Care Integration Combined with Preventive Nursing on Older Patients with Lumbar Disc Herniation During the Perioperative Period
Analysis of the Nursing Effect of Anesthesia Care Integration Combined with Preventive Nursing on Older Patients with Lumbar Disc Herniation During the Perioperative Period Open
Anesthesia care integration combined with preventive nursing has a positive effect on older patients with perioperative LDH, and it significantly improves lumbar spine function, reduces pain, shortens recovery time, and benefits physical a…
View article: Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics
Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics Open
Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, and mild cognitive impairment (MCI) is associated with a high risk of developing AD. Hippocampal morphometry analysis is bel…
View article: Altered gut microbiota and microbial metabolism in children with hepatic glycogen storage disease: a case-control study
Altered gut microbiota and microbial metabolism in children with hepatic glycogen storage disease: a case-control study Open
The hepatic GSD patients in this study presented with gut microbiota dysbiosis which correlated with altered BAs metabolism and fecal SCFAs changes. Further studies are needed to investigate the driver of these changes mediated by either t…
View article: [First-Class Nursing Discipline Construction Spearheads the Cultivation of First-Class Talents].
[First-Class Nursing Discipline Construction Spearheads the Cultivation of First-Class Talents]. Open
Cultivating first-class talents is a key task of the Double First-Class Initiative, a national plan to build a number of world-class universities and disciplines in China by the end of 2050. On the basis of reviewing the history of the dev…
View article: Erratum to “A Low-Cost High-Performance Data Augmentation for Deep Learning-Based Skin Lesion Classification”
Erratum to “A Low-Cost High-Performance Data Augmentation for Deep Learning-Based Skin Lesion Classification” Open
[This corrects the article DOI: 10.34133/2022/9765307.].
View article: Additional file 2 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription
Additional file 2 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription Open
Additional file 2: Table S1. The results of differential expression analysis on RNA-seq data. Table S2. The results of ChIP-seq. Table S3. The 105-overlapping-gene and 23-gene lists. Table S4. Clinicopathological characteristics of OSCC ti…
View article: Additional file 1 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription
Additional file 1 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription Open
Additional file 1: Fig. S1. Identification of SMYD3 for diagnosis of OSCC. A–E ROC curve analyses of SMYD3 in TCGA, meta-GEO, TCGA, GSE37991, and GSE30784 datasets. AUC values are shown. Fig. S2. The DNA methylation and genomic mutation pr…
View article: Is China’s Fishing Capacity Management Sufficient? Quantitative Assessment of China’s Efforts toward Fishing Capacity Management and Proposals for Improvement
Is China’s Fishing Capacity Management Sufficient? Quantitative Assessment of China’s Efforts toward Fishing Capacity Management and Proposals for Improvement Open
As the country with the world’s largest fishing capacity, China suffers from the depletion of living marine resources, mainly caused by overexploitation, the effects of which also distinctly influence global sustainable utilization of mari…
View article: Towards Sustainable Development of Fisheries in the Yellow and East China Seas Shared by South Korea and China
Towards Sustainable Development of Fisheries in the Yellow and East China Seas Shared by South Korea and China Open
South Korea and China are located adjacent to Korea’s West and South Seas and China’s Yellow, Bohai, and East China Seas. These seas are semi-closed and are inhabited by many transboundary species. Korea and China signed a Fisheries Agreem…
View article: A Proposed Scheme of Fishing Quota Allocation to Ensure the Sustainable Development of China’s Marine Capture Fisheries
A Proposed Scheme of Fishing Quota Allocation to Ensure the Sustainable Development of China’s Marine Capture Fisheries Open
The sustainable development of marine capture fisheries (MCFs) plays a significant role in food security, economic development, and employment stability. The lack of information on the sustainability of MCFs, along with the inadequate mana…
View article: Dietary Advanced Glycation End Products Shift the Gut Microbiota Composition and Induce Insulin Resistance in Mice
Dietary Advanced Glycation End Products Shift the Gut Microbiota Composition and Induce Insulin Resistance in Mice Open
Jiao Wang,1– 3,* Wei Cai,4,* Jiao Yu,1 Honghong Liu,1 Shasha He,1 Lingyan Zhu,1– 3 Jixiong Xu1– 3 1Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; …
View article: Combined treatment with niclosamide ethanolamine and artemether combination improves type 1 diabetes via the targeting of liver mitochondria
Combined treatment with niclosamide ethanolamine and artemether combination improves type 1 diabetes via the targeting of liver mitochondria Open
Type 1 diabetes (T1D) is characterized by dysregulated blood glucose and liver metabolism. In previous studies, niclosamide ethanolamine salt (NEN) and artemether (Art) displayed significant hypoglycemic effects. However, their combined th…
View article: Artificial Intelligence Applications in Pathological Diagnosis of Gastric Cancer
Artificial Intelligence Applications in Pathological Diagnosis of Gastric Cancer Open
View article: Artemether attenuates renal tubular injury by targeting mitochondria in adriamycin nephropathy mice.
Artemether attenuates renal tubular injury by targeting mitochondria in adriamycin nephropathy mice. Open
Chronic kidney disease (CKD) is complex and current treatment remains limited. As we know, glomerular injury plays a dominant role in kidney disease progression. However, accumulating evidence demonstrated that renal tubules, rather than b…
View article: Towards Sustainable Development of Fisheries in the Yellow and East China Seas Shared by South Korea and China
Towards Sustainable Development of Fisheries in the Yellow and East China Seas Shared by South Korea and China Open
View article: Blood lead level in Chinese adults with and without coronary artery disease.
Blood lead level in Chinese adults with and without coronary artery disease. Open
BLLs were significantly associated with angiographically diagnosed CAD. Furthermore, BLLs showed excellent predictive value for SXscore, especially for complex coronary artery lesions.
View article: Effect of Hydrogen-Rich Water on Gut Microbiota in Mice With High-Fat Diet
Effect of Hydrogen-Rich Water on Gut Microbiota in Mice With High-Fat Diet Open
Objective: To investigate the effects of hydrogen-rich water (HGRW) on the structure and composition of intestinal microflora in mice fed high-fat diets (HFDs). Materials and Methods : C57BL/6 mice were divided into four groups: (1) normal…
View article: Clinical Characteristics Of Carbapenem Resistant Enterobacteriaceae Bloodstream Infection: A Retrospective Study Among Children
Clinical Characteristics Of Carbapenem Resistant Enterobacteriaceae Bloodstream Infection: A Retrospective Study Among Children Open
Purpose : The clinical features and treatment of Carbapenem resistant Enterobacteriaceae（CRE）bacteremia among children were different from the adults. Clinical studies about CRE infection among children was still lack of enough samples. Th…
View article: Cover Image
Cover Image Open
The cover image is based on the Original Article An amiRNA screen uncovers redundant CBF and ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses by Qingqing Xie et al., https://doi.org/10.1111/pce.140…
View article: Association Between Serum Chemokine Cc-motif Ligand 17 and Prognosis of Patients at Risk for Coronary Heart Disease
Association Between Serum Chemokine Cc-motif Ligand 17 and Prognosis of Patients at Risk for Coronary Heart Disease Open
Background It has been reported chemokine CC-motif ligand 17 (CCL17), an inflammatory mediator modulating T cells function to affect formation and stableness of atherosclerotic plaque and is associated with the severity of coronary heart d…