Honghua Yu
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View article: Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis
Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis Open
Objective To investigate the relationship between leukocyte telomere length (LTL), a biomarker of cellular aging, and both the incidence and severity of age-related cataract (ARC) across cohorts from the UK and China. Methods The multicent…
View article: Optic disc morphometrics as a potential ocular biomarker for depression: evidence from two cross-sectional cohort studies
Optic disc morphometrics as a potential ocular biomarker for depression: evidence from two cross-sectional cohort studies Open
View article: Association of Age-Related Eye Diseases with Comorbidity of Coronary Heart Disease and Depression in a Population-Based Cohort Study
Association of Age-Related Eye Diseases with Comorbidity of Coronary Heart Disease and Depression in a Population-Based Cohort Study Open
The study found that individuals with AREDs had a higher risk of comorbid CHD and depression than of either condition independently. Our findings highlighted the importance of screening for the comorbidity of CHD and depression in the long…
View article: Retinal Photoreceptors and Arterioles Alterations Detected using Adaptive Optics Scanning Laser Ophthalmoscopy in Diabetes and Diabetic Retinopathy
Retinal Photoreceptors and Arterioles Alterations Detected using Adaptive Optics Scanning Laser Ophthalmoscopy in Diabetes and Diabetic Retinopathy Open
Methods: Thirty subjects were recruited in the Guangdong Diabetic Retinopathy Multiple-omics Study (GD-RMOS). Adaptive optics scanning laser ophthalmoscopy (AOSLO) was adopted for image acquisition. An AI-based algorithm conducted quantita…
View article: Association of Income Inequality and Sleep Duration With Cardiovascular Outcomes in China and the UK
Association of Income Inequality and Sleep Duration With Cardiovascular Outcomes in China and the UK Open
Income level and sleep duration independently and jointly affect CVD incidence and mortality. Low income and suboptimal sleep duration are detrimental to cardiovascular health, highlighting the need for public health strategies to address …
View article: Prediction of the risk of developing diabetic retinopathy based on blood molecules and retinal features
Prediction of the risk of developing diabetic retinopathy based on blood molecules and retinal features Open
Background:Diabetic retinopathy (DR) has rapidly become the leading blinding eye disease threatening the working population. We aimed to explore molecular biomarkers and retinal features and build prediction models of DR. Methods: Particip…
View article: Underlying brain and genetic mechanisms linking historic phone use patterns, visual decline, and dementia risk in middle‐aged and older adults
Underlying brain and genetic mechanisms linking historic phone use patterns, visual decline, and dementia risk in middle‐aged and older adults Open
BACKGROUND This study aimed to investigate associations between historic phone use, visual decline, and risk of dementia, as well as underlying biological mechanisms. METHODS A total of 494,359 participants from UK Biobank were included in…
View article: Cross-national differences in the association between estimated cardiorespiratory fitness and depressive symptoms among older adults: findings from three nationwide cohort studies
Cross-national differences in the association between estimated cardiorespiratory fitness and depressive symptoms among older adults: findings from three nationwide cohort studies Open
A higher level of eCRF was associated with reduced depressive symptoms risk in the US (HRS) and England (ELSA) older adults but with increased risk in China (CHARLS), emphasizing the need for nation-specific public health strategies.
View article: A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium Open
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually dec…
View article: Association of wearable device-measured physical activity with full-course diabetic retinopathy and retinal traits: insights from the middle-aged and older adult cohort
Association of wearable device-measured physical activity with full-course diabetic retinopathy and retinal traits: insights from the middle-aged and older adult cohort Open
View article: A cross population study of retinal aging biomarkers with longitudinal pre-training and label distribution learning
A cross population study of retinal aging biomarkers with longitudinal pre-training and label distribution learning Open
View article: Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records
Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records Open
View article: Correction: Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults
Correction: Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults Open
View article: Oculomics: Current concepts and evidence
Oculomics: Current concepts and evidence Open
The eye provides novel insights into general health, as well as pathogenesis and development of systemic diseases. In the past decade, growing evidence has demonstrated that the eye's structure and function mirror multiple systemic health …
View article: Association Between Visual Acuity and Incident Atherosclerotic Cardiovascular Disease: A Longitudinal Test of Mediators
Association Between Visual Acuity and Incident Atherosclerotic Cardiovascular Disease: A Longitudinal Test of Mediators Open
Background: Little is known about the prospective relationship between visual acuity (VA) and atherosclerotic cardiovascular disease (ASCVD) events and the extent to which this association is mediated via potential mediators. This study ai…
View article: Application of Wearable Devices in Diabetes Management
Application of Wearable Devices in Diabetes Management Open
Review Application of Wearable Devices in Diabetes Management Zijing Du 1,2,†, Feifan Zhang 1,†, Yifei Ge 1, Yijiang Liu 3, Honghua Yu 2, Yong Wang 4, Rinkoo Dalan 1,5, and Xiaotao Shen 1,3,* 1 Lee Kong Chian School of Medicine, Nanyang Te…
View article: High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study
High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study Open
Aims Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in …
View article: Evaluating lipid-lowering drug targets for full-course diabetic retinopathy
Evaluating lipid-lowering drug targets for full-course diabetic retinopathy Open
Background Implementing lipid control in patients with diabetes is regarded as a potential strategy for halting the advancement of diabetic retinopathy (DR). This study seeks to use Mendelian randomisation (MR) to assess the causal relatio…
View article: Retinal oculomics and risk of incident aortic aneurysm and aortic adverse events: a population-based cohort study
Retinal oculomics and risk of incident aortic aneurysm and aortic adverse events: a population-based cohort study Open
Background: The asymptomatic onset and extremely high mortality rate of aortic aneurysm (AA) highlight the urgency of early detection and timely intervention. The alteration of retinal vascular features (RVFs) can reflect the systemic vasc…
View article: Genomic determinants of biological age estimated by deep learning applied to retinal images
Genomic determinants of biological age estimated by deep learning applied to retinal images Open
View article: Advancing visual neuroscience: expanding boundaries from bench to bedside
Advancing visual neuroscience: expanding boundaries from bench to bedside Open
View article: Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021
Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 Open
View article: Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity‐related morbidities
Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity‐related morbidities Open
This study aims to investigate the association between metabolomic aging acceleration and body mass index (BMI) phenotypes with mortality and obesity‐related morbidities (ORMs). 85,458 participants were included from the UK Biobank. Metabo…
View article: Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes
Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes Open
View article: Association of childhood-adulthood body size trajectories with risk of micro- and macrovascular complications among individuals with type 2 diabetes: a prospective study
Association of childhood-adulthood body size trajectories with risk of micro- and macrovascular complications among individuals with type 2 diabetes: a prospective study Open
A persistent high body size trajectory from childhood to adulthood is associated with the greatest risk of both micro- and macrovascular complications in individuals with T2D, whereas those who were plumper in childhood but achieved a norm…
View article: Associations of Metabolically Healthy Obesity and Retinal Age Gap
Associations of Metabolically Healthy Obesity and Retinal Age Gap Open
Retinal age gap provides a simple tool for identifying early health risks for MHOW and MHO individuals.
View article: In Utero/Childhood/ Adolescence Exposure to Tobacco Smoke and Elderly-Onset Cataract: A Large Prospective Cohort Study
In Utero/Childhood/ Adolescence Exposure to Tobacco Smoke and Elderly-Onset Cataract: A Large Prospective Cohort Study Open
This study identified cataract-associated risks and suggested interventions like banning youth smoking to reduce future cataract incidence.
View article: Network-based hub biomarker discovery for glaucoma
Network-based hub biomarker discovery for glaucoma Open
Objective Glaucoma is an optic neuropathy and the leading cause of irreversible blindness worldwide. However, the early detection of glaucoma remains challenging, as chronic forms of glaucoma remain largely asymptomatic until considerable …
View article: GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma
GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma Open
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms. However, GWASs of traits affecting primary open angle glaucoma through mechanisms independen…
View article: Predicting vision-threatening diabetic retinopathy in patients with type 2 diabetes mellitus: Systematic review, meta-analysis, and prospective validation study
Predicting vision-threatening diabetic retinopathy in patients with type 2 diabetes mellitus: Systematic review, meta-analysis, and prospective validation study Open
The risk prediction model of VTDR has high discrimination and calibration performance based on validation cohorts. Given its demonstrated effectiveness, there is significant potential to expand the utilisation of this model within clinical…