Huilin Xu
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Author Swipe
View article: Long-term symptom burden in a young, ambulatory cohort after the omicron outbreak in China
Long-term symptom burden in a young, ambulatory cohort after the omicron outbreak in China Open
Introduction At the end of 2022, an outbreak of the Omicron BF.7 and BA.5.2 subvariants of SARS-CoV-2 occurred in China. In this prospective cohort study, we investigated the pattern of development of major symptom burden and influencing f…
View article: Development and Validation of a Lifestyle-Based 10-Year Risk Prediction Model of Colorectal Cancer for Early Stratification: Evidence from a Longitudinal Screening Cohort in China
Development and Validation of a Lifestyle-Based 10-Year Risk Prediction Model of Colorectal Cancer for Early Stratification: Evidence from a Longitudinal Screening Cohort in China Open
Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with growing evidence linking risk to lifestyle and dietary factors. However, nutrition-related exposures have rarely been integra…
View article: Mental Health Issues and 24-Hour Movement Guidelines–Based Intervention Strategies for University Students With High-Risk Social Network Addiction: Cross-Sectional Study Using a Machine Learning Approach
Mental Health Issues and 24-Hour Movement Guidelines–Based Intervention Strategies for University Students With High-Risk Social Network Addiction: Cross-Sectional Study Using a Machine Learning Approach Open
Background The exponential growth of digital technologies and the ubiquity of social media platforms have led to unprecedented mental health challenges among college students, highlighting the critical need for effective intervention appro…
View article: Prognostic factors of survival in patients with lung cancer after low-dose computed tomography screening: a multivariate analysis of a lung cancer screening cohort in China
Prognostic factors of survival in patients with lung cancer after low-dose computed tomography screening: a multivariate analysis of a lung cancer screening cohort in China Open
Objective This study aimed to evaluate the prognostic factors influencing the survival of patients with lung cancer identified from a lung cancer screening cohort in the community. Methods A total of 25,310 eligible participants were enrol…
View article: Dynamic Analysis of Submarine-Buried Pipelines Considering Fluid–Structure Interaction
Dynamic Analysis of Submarine-Buried Pipelines Considering Fluid–Structure Interaction Open
Buried pipes are widely used for submarine water transportation, but the complex operating conditions in the seabed pose challenges for the modeling of buried pipes. In order to more accurately capture the dynamic behavior of the buried pi…
View article: A Novel Capacitor Deionization Performance Study Based on Carbon Nanorods/MnO2 Composite Material
A Novel Capacitor Deionization Performance Study Based on Carbon Nanorods/MnO2 Composite Material Open
The Earth abounds in water resources; however, only 0.4% of the freshwater resources are suitable for drinking. The scarcity of freshwater resources has a severe impact on the sustainable development of human society. Desalination is regar…
View article: Network pharmacology and molecular analysis of mechanisms underlying the therapeutic effects of Rhubarb in treating atherosclerosis and abdominal aortic aneurysm
Network pharmacology and molecular analysis of mechanisms underlying the therapeutic effects of Rhubarb in treating atherosclerosis and abdominal aortic aneurysm Open
This study successfully predicted the molecular functions, pharmacological targets, and pathways associated with Rhubarb for treating AS/AAA. In addition, identified potential active ingredients can be used as a source for AS/AAA drug scre…
View article: Temporal trend and attributable risk factors of cardiovascular disease burden for adults 55 years and older in 204 countries/territories from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021
Temporal trend and attributable risk factors of cardiovascular disease burden for adults 55 years and older in 204 countries/territories from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021 Open
Aims The ageing global population and overall population growth have significantly increased the burden of cardiovascular diseases (CVDs). This study aims to examine global temporal trends in the incidence, disability-adjusted life years (…
View article: Synthesis and evaluation of nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid against HIV-1 protease
Synthesis and evaluation of nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid against HIV-1 protease Open
Thirteen nitrogen-containing derivatives of 3,11-dioxo-olean-12-en-30-oic acid were synthesised by introducing various amino acids and nitrogen-containing heterocyclic groups at the 30-carboxyl group, starting from 18β-glycyrrhetinic acid.…
View article: [Effectiveness Evaluation of Low-dose Spiral Computed Tomography
for Lung Cancer Screening in Minhang District of Shanghai].
[Effectiveness Evaluation of Low-dose Spiral Computed Tomography
for Lung Cancer Screening in Minhang District of Shanghai]. Open
The participants of the screening program are at high-risk of lung cancer. LDCT favors the early-detection of lung cancer and improves 5-year survival of the screened cases, indicating a great potential of LDCT in reducing the disease burd…
View article: Age-Dependent Association Between Body Mass Index and All-Cause Mortality Among Patients with Hypertension: A Longitudinal Population-Based Cohort Study in China
Age-Dependent Association Between Body Mass Index and All-Cause Mortality Among Patients with Hypertension: A Longitudinal Population-Based Cohort Study in China Open
The impact of BMI on all-cause mortality in hypertensive patients varies with age, and moderate weight gain may benefit longevity in middle-aged and older patients.
View article: High Stability Dual Beam Interferometer Sensor for Non-contact Photoacoustic Imaging
High Stability Dual Beam Interferometer Sensor for Non-contact Photoacoustic Imaging Open
As a non-contact photoacoustic sensor, the reflector of one arm of dual beam interferometer sensor is usually composed of the upper surface of the ultrasonic coupling liquid coated on the surface of the sample. The vibration of the outside…
View article: Magnifier or refractor? Exploring the impact of geographical indication on people’s perception of the value of cultural ecosystem services based on the SolVES model
Magnifier or refractor? Exploring the impact of geographical indication on people’s perception of the value of cultural ecosystem services based on the SolVES model Open
Purpose/Significance To a certain extent, geographical indication (GI) protects the ecosystem of product origin, but there is still a lack of quantitative evidence on its cultural spillover effect. The mechanism of the impact of geo-certif…
View article: Critical Analysis of China’s Higher Education Cost-sharing Policy under the Background of Universal Higher Education
Critical Analysis of China’s Higher Education Cost-sharing Policy under the Background of Universal Higher Education Open
China's higher education has entered the stage of universal higher education. This has significantly increased the demand for education funding in the higher education sector and has also brought new requirements for higher education cost-…
View article: Is Chinese Spring Festival a key point for glycemic control of patients with type 2 diabetes mellitus in China?
Is Chinese Spring Festival a key point for glycemic control of patients with type 2 diabetes mellitus in China? Open
Objectives This study aims to explore the long-term trend of fasting blood glucose (FBG) among urban patients with type 2 diabetes mellitus (T2DM) and the impacts of the Chinese Spring Festival on their glycemic control in urban China. Met…
View article: Eliminate the hardware: Mobile terminals-oriented food recognition and weight estimation system
Eliminate the hardware: Mobile terminals-oriented food recognition and weight estimation system Open
Food recognition and weight estimation based on image methods have always been hotspots in the field of computer vision and medical nutrition, and have good application prospects in digital nutrition therapy and health detection. With the …
View article: Long‐term fasting glucose variability and risk of cancer in patients with type 2 diabetes mellitus: A retrospective population‐based cohort study in Shanghai
Long‐term fasting glucose variability and risk of cancer in patients with type 2 diabetes mellitus: A retrospective population‐based cohort study in Shanghai Open
Backgrounds Fasting blood glucose (FBG) variability may make an impact on adverse events in patients with diabetes mellitus. However, the association between long‐term changes in FBG and cancer remains unclear. We aimed to investigate this…
View article: Joint association of smoking and physical activity with mortality in elderly hypertensive patients: A Chinese population-based cohort study in 2007–2018
Joint association of smoking and physical activity with mortality in elderly hypertensive patients: A Chinese population-based cohort study in 2007–2018 Open
Background Although associations of physical activity and smoking with mortality have been well-established, the joint impact of physical activity and smoking on premature mortality among elderly hypertensive population was still unclear. …
View article: A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT
A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT Open
The aggregation of mutant HTT (huntingtin; mHTT) is a hallmark of Huntington disease (HD). mHTT aggregates interact and sequester dozens of proteins and affect diverse key cellular functions. Here we report that TFEB (transcription factor …
View article: Risk Prediction of Second Primary Malignancies in Primary Early-Stage Ovarian Cancer Survivors: A SEER-Based National Population-Based Cohort Study
Risk Prediction of Second Primary Malignancies in Primary Early-Stage Ovarian Cancer Survivors: A SEER-Based National Population-Based Cohort Study Open
Purpose This study aimed to characterize the clinical features of early-stage ovarian cancer (OC) survivors with second primary malignancies (SPMs) and provided a prediction tool for individualized risk of developing SPMs. Methods Data wer…
View article: SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease
SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease Open
Huntington disease (HD) manifests a unique macroautophagy/autophagy defect: the presense of cytosolic autophagosomes without substrates or so-called "empty" autophagosomes. It was proposed that mutant HTT (huntingtin; mHTT) disrupts cargo …
View article: Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China
Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China Open
The aim of our study was to examine the association between body mass index (BMI) and the risk of cardiovascular disease (CVD)-specific mortality among Chinese adults with hypertension by sex. This study included 212,394 adult hypertensive…
View article: Association and Time-Varying Effects of Body Mass Index on All-Cause Mortality in Patients With Hypertension
Association and Time-Varying Effects of Body Mass Index on All-Cause Mortality in Patients With Hypertension Open
BackgroundThe relationship between body mass index (BMI) and mortality in hypertension patients remains controversial. This study aimed to evaluate the association and the time-varying effects of different BMI categories on the risk of all…
View article: An unsupervised semi-automated pulmonary nodule segmentation method based on enhanced region growing
An unsupervised semi-automated pulmonary nodule segmentation method based on enhanced region growing Open
Compared with other algorithms, ReGANS can segment the lung nodule image region more quickly and more precisely. The experimental results show that ReGANS can assist medical imaging diagnosis and has good clinical application value. It als…
View article: Cancer risk in Chinese diabetes patients: a retrospective cohort study based on management data
Cancer risk in Chinese diabetes patients: a retrospective cohort study based on management data Open
The excess risk of cancer observed in patients with type 2 diabetes (T2DM) may have been influenced by detection bias. The aim of this study was to examine the real association by evaluating time-varying site-specific cancer risks in newly…