Hongling Zhao
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View article: The predictive value of triglyceride-glucose index on early neurological functional improvement in non-diabetic patients with acute ischemic stroke undergoing intravenous thrombolysis
The predictive value of triglyceride-glucose index on early neurological functional improvement in non-diabetic patients with acute ischemic stroke undergoing intravenous thrombolysis Open
Objective To explore the predictive role of the triglyceride-glucose index (TyG index) on the early neurological improvement in non-diabetic patients with acute ischemic stroke (AIS) undergoing alteplase intravenous thrombolysis (IV-rtPA).…
View article: Effects of resistance exercise intensity on cerebral blood flow and cerebrovascular reactivity in healthy young males: A pilot study
Effects of resistance exercise intensity on cerebral blood flow and cerebrovascular reactivity in healthy young males: A pilot study Open
Exercise intensity has been shown to elicit different cerebral blood flow velocity (CBFv) responses. This study aimed to compare the acute effects of resistance exercise at different intensities on hemodynamics and cerebrovascular reactivi…
View article: The association between the systemic immune-inflammation index and in-hospital mortality among acute ischemic stroke with atrial fibrillation patients undergoing intravenous thrombolysis
The association between the systemic immune-inflammation index and in-hospital mortality among acute ischemic stroke with atrial fibrillation patients undergoing intravenous thrombolysis Open
Objective This study aimed to explore the relationship between the systemic immune-inflammatory index (SII) and the probability of in-hospital mortality among acute ischemic stroke (AIS) with atrial fibrillation (AF) patients undergoing in…
View article: MRI-based habitat radiomics combined with vision transformer for identifying vulnerable intracranial atherosclerotic plaques and predicting stroke events: a multicenter, retrospective study
MRI-based habitat radiomics combined with vision transformer for identifying vulnerable intracranial atherosclerotic plaques and predicting stroke events: a multicenter, retrospective study Open
This study was supported by the National Natural Science Foundation of China (grant 82204933). Henan Key Laboratory of Neurorestoratology (HNSJXF-2021-004), 2019 Joint Construction Project of Henan Provincial Health Committee and Ministry …
View article: Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report
Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report Open
View article: Standard: Human gastric organoids
Standard: Human gastric organoids Open
View article: Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume
Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume Open
View article: Standard: Human gastric cancer organoids
Standard: Human gastric cancer organoids Open
View article: Anti-GluK2 Antibody-Positive Autoimmune Encephalitis Concurrent with Multiple Myeloma: A Case Report
Anti-GluK2 Antibody-Positive Autoimmune Encephalitis Concurrent with Multiple Myeloma: A Case Report Open
Background It is the first reported instance of GluK2 antibody-associated autoimmune encephalitis with involuntary movement. Case presentation A 60-year-old woman who experienced involuntary movements of her lower limbs and facial muscle f…
View article: Analysis of the relationship between the degree of migraine with right-to-left shunt and changes in white matter lesions and brain structural volume
Analysis of the relationship between the degree of migraine with right-to-left shunt and changes in white matter lesions and brain structural volume Open
Objective To investigate the location of white matter lesions (WMLs) in migraineurs with right-to-left shunt (RLS); the relationships among the severity of WMLs, changes in brain structural volume and RLS shunts; and the relationships amon…
View article: Effects of accumulated exercise on the stiffness and hemodynamics of the common carotid artery
Effects of accumulated exercise on the stiffness and hemodynamics of the common carotid artery Open
Purpose: This research aims to study and compare the effects of moderate-intensity continuous exercise and accumulated exercise with different number of bouts on common carotid arterial stiffness and hemodynamic variables. Methods: Thirty …
View article: Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma
Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma Open
View article: Association between Body Mass Index and Medication-Overuse Headache among Individuals with Migraine: A Cross-Sectional Study
Association between Body Mass Index and Medication-Overuse Headache among Individuals with Migraine: A Cross-Sectional Study Open
Introduction: Medication-overuse headache (MOH) is a secondary chronic headache disorder that occurs in individuals with a pre-existing primary headache disorder, particularly migraine disorder. Obesity is often combined with…
View article: Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China
Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China Open
Background Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misdiagnosis and inadequate treatment of primary headache disorders remain significant challenges, impeding th…
View article: Targeted inhibition of SCF<sup>SKP2</sup>confers anti-tumor activities resulting in a survival benefit in osteosarcoma
Targeted inhibition of SCF<sup>SKP2</sup>confers anti-tumor activities resulting in a survival benefit in osteosarcoma Open
Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged for decades. Although OS is characterized by extensive genomic heterogeneity and instability, RB1 and TP53 have been shown to be the…
View article: SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis
SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis Open
Purpose Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in OS is SKP2 , encoding a substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that SKP2 knoc…
View article: The effects of the coronavirus disease pandemic on intravenous thrombolytic therapy among patients with acute ischemic stroke in Dalian, China
The effects of the coronavirus disease pandemic on intravenous thrombolytic therapy among patients with acute ischemic stroke in Dalian, China Open
Background We investigated the influence of the coronavirus disease 2019 (COVID-19) pandemic on the number of patients with acute ischemic stroke who received intravenous thrombolytic therapy (ITT) in Dalian, China, in 2020. Methods This r…
View article: The Effects of the Coronavirus Disease Pandemicon Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke in Dalian, China
The Effects of the Coronavirus Disease Pandemicon Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke in Dalian, China Open
Objective: We investigated the influence of the coronavirus disease (COVID-19) pandemic on the number of patients with acute ischemic stroke who received intravenous thrombolytic therapy (ITT) in Dalian, China, in 2020. Methods: This retro…
View article: Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition
Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition Open
View article: Are dexmedetomidine and olanzapine suitable to control delirium in critically ill elderly patients? A retrospective cohort study
Are dexmedetomidine and olanzapine suitable to control delirium in critically ill elderly patients? A retrospective cohort study Open
View article: The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma
The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma Open
Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F‐box protein SKP2 is overexpressed in osteosarcoma, acting as a proto‐oncogene; p27 Kip1 …
View article: Association between Deep White Matter Hyperintensities and Right-to-left Shunt in Migraine (CAMBRAIN): A Cross-sectional Multicenter Study
Association between Deep White Matter Hyperintensities and Right-to-left Shunt in Migraine (CAMBRAIN): A Cross-sectional Multicenter Study Open
BackgroundDeep white matter hyperintensities (DWMHs), often identified by hyperintense lesions on T2-weighted magnetic resonance imaging (MRI), were discovered to have a higher prevalence in migraine patients. A right-to-left shunt (RLS), …
View article: Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity
Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity Open
We have defined some of the necessary components to prevent high-fat diet-induced obesity at the molecular and cellular level. Within POMC neurons, the retinoblastoma protein must remain active and prevented from phosphoinactivation by cyc…
View article: Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma
Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma Open
Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity for local recurrence and distant metastasis. In this study, we investigated whether S phase kinase-associated protein (Skp2) plays an oncogeni…
View article: Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in <i>RB1</i> -Deficient Human and Mouse Small-Cell Lung Cancer
Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in <i>RB1</i> -Deficient Human and Mouse Small-Cell Lung Cancer Open
The RB1 tumor suppressor gene is mutated in highly aggressive tumors including small-cell lung cancer (SCLC), where its loss, along with TP53, is required and sufficient for tumorigenesis. While RB1-mutant cells fail to arrest at G1–S in r…
View article: Is Dexmedetomidine or Olanzapine Suitable to Control Delirium in Elder Critical Ill Patients?: A Retrospective Cohort Study
Is Dexmedetomidine or Olanzapine Suitable to Control Delirium in Elder Critical Ill Patients?: A Retrospective Cohort Study Open
View article: Sensitivity of contrast-enhanced transthoracic echocardiography for the detection of residual shunts after percutaneous patent foramen ovale closure
Sensitivity of contrast-enhanced transthoracic echocardiography for the detection of residual shunts after percutaneous patent foramen ovale closure Open
The objective of this study is to investigate the sensitivity of contrast-enhanced transthoracic echocardiography (c-TTE) versus transesophageal echocardiography (TEE) to detect a residual right-to-left shunt (RLS) following a transcathete…
View article: Synthesis, in vitro stability, and antiproliferative effect of <scp>d</scp>‐cysteine modified GnRH‐doxorubicin conjugates
Synthesis, in vitro stability, and antiproliferative effect of <span>d</span>‐cysteine modified GnRH‐doxorubicin conjugates Open
Overexpression of gonadotropin‐releasing hormone (GnRH) receptor in many tumors but not in normal tissues makes it possible to use GnRH analogs as targeting peptides for selective delivery of cytotoxic agents, which may help to enhance the…
View article: What influenced the lesion patterns and hemodynamic characteristics in patients with internal carotid artery stenosis? A retrospective study
What influenced the lesion patterns and hemodynamic characteristics in patients with internal carotid artery stenosis? A retrospective study Open
This study aimed to explore the dynamic changes of lesion patterns and hemodynamic characteristics in patients with internal carotid artery stenosis (ICAS).Patients who had suffered an acute ischemic stroke in the distribution of ipsilater…
View article: Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis
Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis Open
Tumor suppressor pRb represses Skp2, a substrate-recruiting subunit of the SCF(Skp2) ubiquitin ligase. Rb1(+/-) mice incur "two-hit" pituitary tumorigenesis; Skp2(-/-);Rb1(+/-) mice do not. Rb1(-/-) embryos die on embryonic day (E) 14.5-15…