Explanipedia

Synergistic Enhancement of Photoredox Catalysis Beyond the Singlet Bottleneck Through Triplet Charge Recombination and Magnetic Field Effects Open

Ming‐Li Sun, Chenli Chen, L.‐W. Antony Chen, Jiayi Liang, Jie Cheng , et al. · 2025

Organic photosensitizers with redox‐active excited states have revitalized photoredox catalysis, but their efficiency is often hindered by spontaneous back electron transfer (BET), particularly in singlet‐driven pathways. Enhancing triplet…

A Charge Transfer Mediated Sequential Triplet Energy Transfer Model Beyond the Dexter Limit in Organic Photocatalysis Open

Lin Liu, Yibo Shi, Jialong Jie, Xiao Liu, Qian Wang , et al. · 2025

Classical distance-dependent Dexter energy transfer models fail to account for the complex, geometry-sensitive kinetics observed in flexible and dynamically disordered organic photocatalytic systems. To resolve these persistent inconsisten…

Photocatalytic streamlined dual-functional group transfer from cyanopyridine to internal alkynes Open

Xiaogang Tong, Jialong Jie, Yan Liu, Haihan Yu, Mingquan Yuan , et al. · 2025

Hepatoma Metastasis‐Inhibiting Supramolecular Nanoglycocalyx for Enhanced Type I Photodynamic Therapy Open

Yichen Liu, Gai‐li Feng, Jialong Jie, Wei Zhou, Guang‐jian Liu , et al. · 2025

Type I photodynamic therapy (PDT) is well demonstrated to have low oxygen dependency. However, fully suppressing the risk of hypoxia‐induced tumor metastasis during PDT remains a great challenge. In this study, a tetra‐lactosylated amphiph…

Single electron/energy transfer photocatalysis: α-/β-switchable synthesis of 3-deoxy-d-manno-oct-2-ulosonic acid O-glycosides Open

Jingdong Zhang, Jialong Jie, Shuyi Yan, Hui Zhang, Jiameng Chen , et al. · 2025

An acetonitrile/( p -Tol) 2 SO dual mediated photocatalytic IrIII/CuII-catalysed Kdo O -glycosidation was developed to synthesize α-/β-Kdo O -glycosides in good to excellent yields via a dual pathway (SET & EnT) photoactivation and a S N 2…

Enhancing photoredox catalysis by suppressing back electron transfer with the aid of a spin catalyst Open

Zhiqiang Dong, Chenli Chen, Lingfang Chen, Mingli Sun, Jun-Zheng Zhan , et al. · 2025

We report an exceptional role of Gd complex as a spin catalyst in enhancing photoredox reaction by promoting the singlet-to-triplet spin conversion of radical pair intermediates and suppressing back electron transfer.

Response Patterns of Acoustic Wave Characteristics to Reservoir Petrophysical Parameters in Different Bedding Directions: A Case Study of Low- and Middle-Rank Coals in Xinjiang, China Open

Liang Du, Jia Chao, Haichao Wang, Pichen Sun, Yifan Chen , et al. · 2024

The physical properties of coal reservoirs, important parameters for evaluating the production potential of coalbed methane (CBM) resources, can be assessed nondestructively and in real-time using acoustic wave technology. In this study, w…

Alteration of the Expression and Functional Activities of Myosin II Isoforms in Enlarged Hyperplastic Prostates Open

Xiao Wang, Weixiang He, H. Chen, Rui Yang, Hongmei Su , et al. · 2024

Introduction: Benign prostatic hyperplasia (BPH) is a common pathologic process in aging men, and the contraction of the prostatic smooth muscles (SMs) in the stroma plays a vital role in this pathogenesis, leading to lower urinary tract s…

Dual Functionality of 6-Methylthioguanine: Synergistic Effects Enhancing the Photolability of DNA Nucleobases Open

Qian Zhou, Yuxia Hao, Jialong Jie, Shuo Wang, Ye Xia , et al. · 2024

A small chemical modification of the nucleobase structure can significantly enhance the photoactivity of DNA, which may incur DNA damage, thus holding promising applications in photochemotherapy treatment of cancers or pathogens. However, …

Multiphoton tandem photoredox catalysis of [Ir(dFCF3ppy)2(dtbbpy)]+ facilitating radical acylation reactions Open

Zhicong Lin, Qian Zhou, Yan Liu, Chenli Chen, Jialong Jie , et al. · 2024

Rather than a single-photon cycle, a multiphoton tandem photoredox catalysis mechanism is found to be responsible for the [Ir(dFCF 3 ppy) 2 (dtbbpy)]+ photocatalytic α-keto acids radical acylation reactions.

Reducing Hepatotoxicity Mechanism of Radix Wikstroemia Indica byProcessing with “Sweat Soaking Method” Using UPLC-MS/MS and aCocktail Probe Substrate Open

Hongmei Su, Guo Feng, Qin Xu, Wěi Li, Wen Liu , et al. · 2023

Background: Radix Wikstroemia indica is a traditional Chinese medicine (TCM) used as anti-inflammatory and anti-tumor drug. However, it has serious hepatotoxicity, "Sweat soaking method" processed could effectively decrease its hepatotoxic…

H-NMR-based metabolomics study on the effects of raw and processed radix Wikstroemia indica on endogenous metabolites in rat plasma Open

Xueli Song, Guo Feng, Lailai Li, Wei Li, Zengguang Wu , et al. · 2023

Based on metabolomics, to study the mechanism of Radix Wikstroemia indica (RWI) “Sweat soaking method” processing detoxification. The raw drug group and processed products was given raw RWI and processed RWI respectively by gavage. The con…

Exploring the processing-related components from asparagi radix via diversified spectrum-effect relationship Open

Guanglin Zhu, Bing Wang, Guo Feng, An-Xian HUANG, Guo Yin , et al. · 2022

Asparagi radix (AR) is a widely used in traditional Chinese medicines (TCMs). It is well-known for the antiaging effect, but the responsible for effective components from AR remained unknown. Herein, this study aimed to establish a seemly …

A nano-preparation approach to enable the delivery of daphnoretin to potentiate the therapeutical efficacy in hepatocellular cancer Open

Guanglin Zhu, Bing Wang, Guo Feng, Zhirong Zhou, Wei Li , et al. · 2022

Daphnoretin (DAP), isolated from a traditional Chinese medicine Wikstroemia indica (Linn. C. A. Meyer), could induce apoptosis of hepatocellular cancer (HCC) and inhibit tumor growth. However, the application of DAP in cancer therapies was…

Reminiscence therapy-based care program serves as an optional nursing modality in alleviating anxiety and depression, improving quality of life in surgical prostate cancer patients Open

Ting Huang, Hongmei Su, Shi Zhang, Yawen Huang · 2022

CCDC 2034034: Experimental Crystal Structure Determination Open

Peng Lian, L. Zhang, Hongmei Su, J. Chen, L. Chen , et al. · 2022

CCDC 1504577: Experimental Crystal Structure Determination Open

Si‐Hai Wu, Jiang‐Yang Shao, Xiaojuan Dai, Xiuling Cui, Hongmei Su , et al. · 2021

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1504578: Experimental Crystal Structure Determination Open

Si‐Hai Wu, Jiang‐Yang Shao, Xiaojuan Dai, Xiuling Cui, Hongmei Su , et al. · 2021

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1504575: Experimental Crystal Structure Determination Open

Si‐Hai Wu, Jiang‐Yang Shao, Xiaojuan Dai, Xiuling Cui, Hongmei Su , et al. · 2021

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Reactivity and DNA Damage by Independently Generated 2′-Deoxycytidin-N4-yl Radical Open

Haihui Peng, Jialong Jie, Ifor P. Mortimer, Zehan Ma, Hongmei Su , et al. · 2021

Oxidative stress produces a variety of radicals in DNA, including pyrimidine nucleobase radicals. The nitrogen-centered DNA radical 2'-deoxycytidin-N4-yl radical (dC·) plays a role in DNA damage mediated by one electron oxidants, su…

Ultrafast excited state dynamics and light-switching of [Ru(phen)2(dppz)]2+ in G-quadruplex DNA Open

Chunfan Yang, Qian Zhou, Zeqing Jiao, Hongmei Zhao, Chun‐Hua Huang , et al. · 2021

The triplet metal to ligand charge transfer ( 3 MLCT) luminescence of ruthenium (II) polypyridyl complexes offers attractive imaging properties, specifically towards the development of sensitive and structure-specific DNA probes. However, …

Mechanism of transmembrane and coiled‑coil domain 1 in the regulation of proliferation and migration of A549 cells Open

Yang Chen, Yuan Wang, Jian-Qi Bai, Jingru Zhang, Pei-Yan Hu , et al. · 2020

Bioinformatics analyses have shown that transmembrane and coiled-coil domain 1 (TMCO1) may be associated with lung adenocarcinoma. However, to the best of our knowledge, no current research has determined whether TMCO1 is involved in the d…

Independent Generation and Time‐Resolved Detection of 2′‐Deoxyguanosin‐N2‐yl Radicals Open

Liwei Zheng, Xiaojuan Dai, Hongmei Su, Marc M. Greenberg · 2020

Guanine radicals are important reactive intermediates in DNA damage. Hydroxyl radical (HO . ) has long been believed to react with 2′‐deoxyguanosine (dG) generating 2′‐deoxyguanosin‐N1‐yl radical (dG(N1‐H) . ) via addition to the nucleobas…

Elucidating heterogeneous photocatalytic superiority of microporous porphyrin organic cage Open

Chao Liu, Kunhui Liu, Chiming Wang, Heyuan Liu, Hailong Wang , et al. · 2020

Rational design of an “all-in-one” phototheranostic Open

Zi‐Shu Yang, Yuhang Yao, Adam C. Sedgwick, Cuicui Li, Ye Xia , et al. · 2020

We report here porphodilactol derivatives and their corresponding metal complexes as “all-in-one” phototheranostics by controlling the relationship between intersystem crossing (ISC) and photothermal conversion efficiency following photoex…

Sulfur-centered hemi-bond radicals as active intermediates in S-DNA phosphorothioate oxidation Open

Jialong Jie, Ye Xia, Chun‐Hua Huang, Hongmei Zhao, Chunfan Yang , et al. · 2019

Phosphorothioate (PS) modifications naturally appear in bacteria and archaea genome and are widely used as antisense strategy in gene therapy. But the chemical effects of PS introduction as a redox active site into DNA (S-DNA) is still poo…

Photo-induced Electron Transfer between 4-Thiouracil and Tryptophan Open

Qige Qi, Chunfan Yang, Xia Ye, Kunhui Liu, Hongmei Su · 2019

b ( a 中国科学院化学研究所北京分子科学国家实验室北京 100190) ( b 北京师范大学化学学院北京 100875) ( c 中国科学院大学北京 100049) 摘要 RNA 与蛋白质相互作用是生物体进行生命活动的基础, 光活化核苷酸引发的共价交联是研究其相互作用的有效手段.对其机理的研究有助于理解并调控交联的位点及氨基酸, 因此探测关键的中间体来揭示机理很有必要. 本工作选择光活化核苷酸 4-硫代尿嘧啶(4-TU)和色氨酸(TrpH)为模型体系, 通过…

Binding Interactions of Zinc Cationic Porphyrin with Duplex DNA: From B-DNA to Z-DNA Open

Ting‐Xiao Qin, Kunhui Liu, Di Song, Chunfan Yang, Hongmei Zhao , et al. · 2018

Recognition of unusual left-handed Z-DNA by specific binding of small molecules is crucial for understanding biological functions in which this particular structure participates. Recent investigations indicate that zinc cationic porphyrin …

(Salen)Mn(iii)-catalyzed chemoselective acylazidation of olefins Open

Liang Zhang, Shuya Liu, Zhiguo Zhao, Hongmei Su, Jingcheng Hao , et al. · 2018

A (salen)Mn(iii)-catalyzed chemoselective acylazidation of olefins was developed based on strategic application of the distinct reactivity of oxomanganese(v) species.

Photochemical reaction dynamics studies of nucleic acids Open

Chunfan Yang, Kunhui Liu, Hongmei Zhao, Di Song, Hongmei Su · 2017

acid, RNA)两类, 是生物体遗传物质及基因信息表达、存储和传递的载体

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