Hongmei Yang
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View article: Potential of Traditional Chinese Medicine Brucea javanica in Cancer Treatment: A Review of Chemical Constituents, Pharmacology, and Clinical Applications
Potential of Traditional Chinese Medicine Brucea javanica in Cancer Treatment: A Review of Chemical Constituents, Pharmacology, and Clinical Applications Open
Brucea javanica (BJ), a key representative of traditional Chinese herbal medicine, is derived from the dried mature fruit of Brucea javanica (L.) Merr., a plant in the Simaroubaceae family. Its pharmacological activity is largely attribute…
View article: A pilot study on the application of ISOBAR combined with case teaching method in pediatric resident nurses’ clinical handover
A pilot study on the application of ISOBAR combined with case teaching method in pediatric resident nurses’ clinical handover Open
Not applicable, as the study is not a trial.
View article: Safety Design of Rotary Drilling Rig Mast Based on Multi-Condition Analysis
Safety Design of Rotary Drilling Rig Mast Based on Multi-Condition Analysis Open
To achieve both safety and a lightweight design for rotary drilling rig masts, this study proposes an optimization method incorporating safety evaluation constraints. The method employs the limit state method to validate the mast structure…
View article: Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice
Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice Open
Black ginseng (BG) is of great interest for its anti-cancer property. Its detailed mechanism, however, is still lacking. This study aims to evaluate the effectiveness of ginsenosides 20R-Rg3 and Rg5 enriched BG (Rg3/Rg5-BG), innovatively p…
View article: Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline
Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline Open
Objective Type 2 diabetes mellitus (T2DM) over time predisposes to inflammatory responses and abnormalities in functional brain networks that damage learning, memory, or executive function. The hippocampus is a key region often reporting c…
View article: Ginsenoside Rd reduces cell proliferation of non-small cell lung cancer cells by p53-mitochondrial apoptotic pathway
Ginsenoside Rd reduces cell proliferation of non-small cell lung cancer cells by p53-mitochondrial apoptotic pathway Open
View article: Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA
Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA Open
Circulating tumor cells (CTCs) shed from primary tumors must overcome the cytotoxicity of immune cells, particularly natural killer (NK) cells, to cause metastasis. The tumor microenvironment (TME) protects tumor cells from the cytotoxicit…
View article: Correction to: Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways
Correction to: Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways Open
View article: Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons
Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons Open
In Alzheimer's disease (AD), dysfunctional mitochondrial metabolism is associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, compar…
View article: Editorial: Free radicals and antioxidants in diseases associated with immune dysfunction, inflammatory process, and aberrant metabolism
Editorial: Free radicals and antioxidants in diseases associated with immune dysfunction, inflammatory process, and aberrant metabolism Open
EDITORIAL article Front. Endocrinol., 16 January 2024Sec. Molecular and Structural Endocrinology Volume 15 - 2024 | https://doi.org/10.3389/fendo.2024.1363854
View article: Metabolic bypass rescues aberrant S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
Metabolic bypass rescues aberrant S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons Open
SUMMARY In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism is associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here…
View article: An Empirical Investigation into the Determinants of Student Participation in Virtual Reality-Based Practical Training Programs at Yellow River Conservancy Technical Institute
An Empirical Investigation into the Determinants of Student Participation in Virtual Reality-Based Practical Training Programs at Yellow River Conservancy Technical Institute Open
This study aims to explore the factors influencing student engagement in virtual reality training projects at Yellow River Conservancy Technical Institute. In vocational education and practical teaching, internship and practical training a…
View article: S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons Open
View article: Application of nanodrugs in the treatment of cardiovascular diseases
Application of nanodrugs in the treatment of cardiovascular diseases Open
Cardiovascular disease is still a disease with high incidence rate and mortality. Although advanced technology continues to increase our understanding of cardiovascular disease, its diagnosis and treatment still have limitations. As an eme…
View article: Advances in the Use of Nanomaterials in TumourTherapy: Challenges and Prospects
Advances in the Use of Nanomaterials in TumourTherapy: Challenges and Prospects Open
Nanomaterials have shown great potential in anti-tumor applications and are currently the focus of research. This review article aims to provide a comprehensive overview of the challenges encountered in oncology treatment and how nanomater…
View article: Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects
Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects Open
Nanomaterials have shown great potential in anti-tumor applications and are currently the focus of research. This review article aims to provide a comprehensive overview of the challenges encountered in oncology treatment and how nanomater…
View article: Place-bound memory and people-bound memory affecting destination loyalty in the food tourism industry
Place-bound memory and people-bound memory affecting destination loyalty in the food tourism industry Open
It is significant to promote food tourism behavior. This paper aims to build a comprehensive behavior model of tourists suitable for food tourism to promote such tourism in Chongqing city, China. The paper deals with the place-bound and pe…
View article: Interaction of isoquinoline alkaloids with pyrimidine motif triplex DNA by mass spectrometry and spectroscopies reveals diverse mechanisms
Interaction of isoquinoline alkaloids with pyrimidine motif triplex DNA by mass spectrometry and spectroscopies reveals diverse mechanisms Open
View article: Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway
Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway Open
These results demonstrated that SZP improved intestinal flora disorder and inhibited the TLR4/NF-κB/NLRP3 pathway to alleviate DN.
View article: <scp>BASP1</scp> promotes high glucose‐induced endothelial apoptosis in diabetes <i>via</i> activation of <scp>EGFR</scp> signaling
<span>BASP1</span> promotes high glucose‐induced endothelial apoptosis in diabetes <i>via</i> activation of <span>EGFR</span> signaling Open
Aims Diabetes mellitus is a common chronic disease of glucose metabolism. Endothelial dysfunction is an early event in diabetes complicated by cardiovascular disease. This study aimed to reveal the expression of BASP1 and its biological ro…
View article: PFOS Induces Lipometabolism Change, Immune Defense, and Endocrine Disorders in Black-Spotted Frogs: Application of Transcriptome Profiling
PFOS Induces Lipometabolism Change, Immune Defense, and Endocrine Disorders in Black-Spotted Frogs: Application of Transcriptome Profiling Open
Amphibian population declines are closely linked to increasingly serious environmental pollution. Field investigations revealed that perfluorooctane sulfonic acid (PFOS) distribution was detected in 100% of amphibians. In the present study…
View article: Synthesis of New Sulfur-free and Phosphorus-free Ether-ester and Study on Its Properties As Ashless Friction Modifier
Synthesis of New Sulfur-free and Phosphorus-free Ether-ester and Study on Its Properties As Ashless Friction Modifier Open
b ( a 昆明理工大学 材料科学与工程学院 云南昆明 650093) ( b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032) ( c 上海理工大学 材料与化学学院 上海 200093) 摘要 伴随机械设备的升级换代和"双碳"政策的推行实施, 长换油周期、清洁环保的高品质润滑油需求与日俱增, 而 新型添加剂和基础油以及二者之间配伍规律的研究始终贯穿于高性能润滑油的研发.摩擦改进剂作为提升低粘化油品 耐久性润滑保护及燃油经济性至关重要的一类添加…
View article: Knowledge map of digital tourism: A bibliometric approach using CiteSpace
Knowledge map of digital tourism: A bibliometric approach using CiteSpace Open
Digital tourism is an essential product of the digital economy, which is significant in promoting sustainable tourism. The study aims to analyze the current research status of digital tourism with the CiteSpace tool. One thousand thirteen …
View article: Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3
Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3 Open
Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer’s disease (AD). To identify SNO proteins in AD brains, we used triar…
View article: The Perspectives of Students on the Lecturers’ Creativity: A Qualitative Analysis of the Data From Private Higher Educational Institutions in China
The Perspectives of Students on the Lecturers’ Creativity: A Qualitative Analysis of the Data From Private Higher Educational Institutions in China Open
Private higher educational institutions (PHEIs) have always been an essential part of the education industry, and lecturers are a necessary driving force for development. However, there are few studies on lectures’ creativity in PHEIs. Thi…
View article: Effect of Bacillus velezensis Treatment on the Preservation Effect of Muskmelon and Protective Enzyme Activity
Effect of Bacillus velezensis Treatment on the Preservation Effect of Muskmelon and Protective Enzyme Activity Open
In order to explore the effects of antagonistic bacterium treatment on the preservation effect and protective enzyme activity of muskmelon, this study selected Xizhoumi 25 melon as the research object, and inoculated the melon surface with…
View article: Teaching Applied Piano Singing While Playing Based on Xindi Applied Piano Pedagogy: Taking Fujian Vocational College of Art as an Example
Teaching Applied Piano Singing While Playing Based on Xindi Applied Piano Pedagogy: Taking Fujian Vocational College of Art as an Example Open
As known to all, China has witnessed remarkable development in addition to its effective implementation of the “double reduction” policy. Under such circumstance, the piano has drawn more interest and parental affection as a vital course t…
View article: Research on the Teaching Quality Management of “Xindi Applied Piano Pedagogy”
Research on the Teaching Quality Management of “Xindi Applied Piano Pedagogy” Open
Xindi Applied Piano Pedagogy (XAPP) is one of the key achievements of Chinese music education reform in recent years, reflecting the booming of piano education in China. Twenty years after its establishment, the pedagogy has been widely ac…
View article: Perspectives on Open Educational Resources by University Students in Jiangxi Province of China: An Interview Analysis With UTAUT2 Model Framework
Perspectives on Open Educational Resources by University Students in Jiangxi Province of China: An Interview Analysis With UTAUT2 Model Framework Open
Open educational resources (OER) have become crucial for university students to explore as a shared digital resource. Although some accomplishments have been made in the research on OER adoption domestically and globally, there are three p…
View article: Distinctive carbohydrate profiles of black ginseng revealed by IM-MS combined with PMP labeling and multivariate data analysis
Distinctive carbohydrate profiles of black ginseng revealed by IM-MS combined with PMP labeling and multivariate data analysis Open