Hongmin Wu
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View article: Classification of dark night environment level standards of National Astronomical Observatories, Chinese Academy of Sciences (NAOC), has been released
Classification of dark night environment level standards of National Astronomical Observatories, Chinese Academy of Sciences (NAOC), has been released Open
View article: Full length transcriptomic profiling reveals insights into the white coat phenotype in Waardenburg syndrome mice harboring the Mitf R324del mutation
Full length transcriptomic profiling reveals insights into the white coat phenotype in Waardenburg syndrome mice harboring the Mitf R324del mutation Open
View article: Protocol for CRISPR-mediated deletion of cis-regulatory element in murine Th17 cells for in vivo assessment of effector function
Protocol for CRISPR-mediated deletion of cis-regulatory element in murine Th17 cells for in vivo assessment of effector function Open
Studying the cis-regulatory elements (CREs) of genes in Th17 cells during autoimmune disease progression, such as experimental autoimmune encephalomyelitis (EAE), is often limited by the availability of gene-edited mice. Here, we present a…
View article: Enhance Memory CD8<sup>+</sup>T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness
Enhance Memory CD8<sup>+</sup>T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness Open
Memory CD8 + T cells are pivotal for long-term anti-tumor immunity due to their longevity and rapid response upon encountering tumor cells. Hematopoietic progenitor kinase 1 (HPK1), a member of the Ste20 family of kinases, restricts proxim…
View article: An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study
An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study Open
Current tools for predicting the thrombolysis risk in patients after stroke exhibit limited event prediction in early post-thrombolysis hemorrhagic events. This highlights an unmet medical need to improve the tools for stroke management. W…
View article: Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation
Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation Open
Dilated cardiomyopathy (DCM) is a myocardial disorder resulting in a substantial decline in cardiac function and potentially leading to heart failure. This research combines bioinformatics analysis with empirical validation to explore the …
View article: Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection
Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection Open
T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17 responses remain unclear. Retinoid-related orphan receptor γ t (RORγt) is a master t…
View article: Cancer-associated SF3B1-K700E mutation controls immune responses by regulating T <sub>reg</sub> function via aberrant <i>Anapc13</i> splicing
Cancer-associated SF3B1-K700E mutation controls immune responses by regulating T <sub>reg</sub> function via aberrant <i>Anapc13</i> splicing Open
Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic malignancies, with SF3B1-K700E being the most common one. Here, we show that regulatory T cell (T reg )–specific expression of SF3B1-K70…
View article: Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function
Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function Open
Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of co-activators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in C…
View article: Supplementary Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function
Supplementary Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function Open
All supplementray figures and tables
View article: Supplementary Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function
Supplementary Data from Ncoa2 promotes CD8+ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function Open
All supplementray figures and tables
View article: Nrf2 as a therapy target for Th17-dependent autoimmune disease
Nrf2 as a therapy target for Th17-dependent autoimmune disease Open
Th17 cells are a subset of IL-17-expressing CD4+ T helper cells and play a predominant role in the pathogenesis of autoimmune diseases such as multiple sclerosis and psoriasis. Th17 cells sustain their activation and effector functions pri…
View article: Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy
Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy Open
Steroid receptor coactivator (SRC) family members (SRC1, SRC2 and SRC3) are transcriptional co-regulators. SRCs orchestrate gene transcription by inducing transactivation of nuclear receptors and other transcription factors. Overexpression…
View article: Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function Open
Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of coactivators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in CD…
View article: Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function Open
Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of coactivators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in CD…
View article: Supplementary Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Supplementary Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function Open
All supplementray figures and tables
View article: Supplementary Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Supplementary Data from Ncoa2 Promotes CD8<sup>+</sup> T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function Open
All supplementray figures and tables
View article: Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function Open
Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of coactivators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in CD…
View article: SRC2 controls CD4 <sup>+</sup> T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter <i>Slc7a5</i>
SRC2 controls CD4 <sup>+</sup> T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter <i>Slc7a5</i> Open
T cell activation stimulates substantially increased protein synthesis activity to accumulate sufficient biomass for cell proliferation. The protein synthesis is fueled by the amino acids transported from the environment. Steroid nuclear r…
View article: Decoupling the role of RORγt in the differentiation and effector function of T <sub>H</sub> 17 cells
Decoupling the role of RORγt in the differentiation and effector function of T <sub>H</sub> 17 cells Open
RORγt is known to instruct the differentiation of T helper 17 (T H 17) cells that mediate the pathogenesis of autoimmune diseases. However, it remains unknown whether RORγt plays a distinct role in the differentiation and effector function…
View article: Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T <sub>reg</sub> differentiation via up-regulating Nr4a2
Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T <sub>reg</sub> differentiation via up-regulating Nr4a2 Open
Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (T regs ) critical for establishing immune tolerance, we show here that SRC2…
View article: A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation
A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation Open
NRH ameliorates aminoglycoside-induced ototoxicity by inhibiting HC apoptosis by activating SIRT1 and decreasing ROS. NRH is an effective therapeutic option for aminoglycoside-induced ototoxicity.
View article: Generation of an integration-free induced pluripotent stem cell line (JTUi004-A) from an otosclerosis patient
Generation of an integration-free induced pluripotent stem cell line (JTUi004-A) from an otosclerosis patient Open
Otosclerosis is caused by abnormal bone remodeling in the middle ear, resulting in progressive hearing loss, dizziness, balance problems, and tinnitus. Previous infection, stress fractures of the bony tissue surrounding the inner ear, immu…
View article: Effect of Femoral Nerve Block with Different Concentrations of Chloroprocaine on the Recovery of Joint Function in Rehabilitation Training after Knee Replacement: A Prospective, Double-Blind, Randomized, Controlled Clinical Study
Effect of Femoral Nerve Block with Different Concentrations of Chloroprocaine on the Recovery of Joint Function in Rehabilitation Training after Knee Replacement: A Prospective, Double-Blind, Randomized, Controlled Clinical Study Open
Background: Patients who undergo total knee arthroplasty (TKA) experience severe pain after surgery. Especially active pain in early postoperative rehabilitation training of the knee joint is particularly severe, and it should receive peop…
View article: Maslinic Acid Activates Renal Ampk/sirt1 Signaling Pathway to Protect Against Diabetic Nephropathy in Mice
Maslinic Acid Activates Renal Ampk/sirt1 Signaling Pathway to Protect Against Diabetic Nephropathy in Mice Open
Background Diabetic nephropathy has been a devastating complication. Clinically, there is an urgent need for nephroprotective agents to delay the onset of diabetic nephropathy and ameliorate its symptoms. Maslinic acid is a pentacyclic tri…
View article: Effects of the p16/cyclin D1/CDK4/Rb/E2F1 pathway on aberrant lung fibroblast proliferation in neonatal rats exposed to hyperoxia
Effects of the p16/cyclin D1/CDK4/Rb/E2F1 pathway on aberrant lung fibroblast proliferation in neonatal rats exposed to hyperoxia Open
p16INK4a (p16) inhibits the vital G1 to S phase transition during cell cycle progression through the p16/cyclin D1/CDK4/retinoblastoma(Rb)/E2F1 pathway. Hyperoxia can suppress the G1/S checkpoint and induce…
View article: Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression
Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression Open
Hypergravity conditions may subject the kidney to intrinsic stress and lead to hemodynamic kidney dysfunction. However, the mechanisms underlying this phenomenon remain unclear. Accumulation of unfolded proteins in the endoplasmic reticulu…
View article: UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease
UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease Open
It is widely accepted that genetic polymorphisms impact atorvastatin (ATV) metabolism, clinical efficacy, and adverse events. The objectives of this study were to identify novel genetic variants influencing ATV metabolism and outcomes in C…
View article: Establishment of an iPSC line (JTUi002-A) from a patient with Waardenburg syndrome caused by a SOX10 mutation and carrying a GJB2 mutation
Establishment of an iPSC line (JTUi002-A) from a patient with Waardenburg syndrome caused by a SOX10 mutation and carrying a GJB2 mutation Open
View article: Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study Open
Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health ch…