Hongmei Zhao
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View article: Challenges and breakthroughs: current landscape and future prospects of CAR-T cell therapy clinical trials for solid tumors
Challenges and breakthroughs: current landscape and future prospects of CAR-T cell therapy clinical trials for solid tumors Open
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated significant efficacy in the treatment of hematological malignancies; however, its application in the solid tumor setting remains challenging. Given that solid tumors account…
View article: Epidemiological Investigation and Phylogenetic Analysis of Bovine Respiratory Disease Complex in Northern China
Epidemiological Investigation and Phylogenetic Analysis of Bovine Respiratory Disease Complex in Northern China Open
Bovine respiratory disease complex (BRDC), a multifactorial syndrome driven by viral and bacterial co‐infections, poses significant challenges to cattle health in northern China. We performed a large‐scale epidemiological and phylogenetic …
View article: Diagnosing habitat degradation of submerged plants in urban lakes: An integrated analysis of underwater light limitation, lake optics, and DOM chemo-diversity
Diagnosing habitat degradation of submerged plants in urban lakes: An integrated analysis of underwater light limitation, lake optics, and DOM chemo-diversity Open
Urban lakes are vital socio-economic and ecological assets, yet their aesthetically pleasant clear water states often degrade along with losses of submerged plants. Restoration failures are frequently due to ambiguous linkages between stre…
View article: PTX3 as a diagnostic and prognostic biomarker in lung adenocarcinoma: a comprehensive analysis
PTX3 as a diagnostic and prognostic biomarker in lung adenocarcinoma: a comprehensive analysis Open
PTX3 emerges as a dual biomarker for LUAD diagnosis and prognosis, with mechanistic ties to TME remodeling and therapeutic resistance, highlighting its potential for clinical translation.
View article: Bronchial stenosis requires vigilance against tracheal mucormycosis: a case report
Bronchial stenosis requires vigilance against tracheal mucormycosis: a case report Open
This report highlights the importance of differentiating the etiology of dyspnea and tracheal stenosis. While acknowledging that tracheal stenosis can significantly cause respiratory distress, we emphasize the need to consider tracheal muc…
View article: Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients
Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients Open
These findings not only deepen our structural understanding of various intestinal polyp subtypes but also offer valuable insights that may inform the diagnosis of patients with these conditions.
View article: Major Causative Bacteria of Dairy Cow Mastitis in the Inner Mongolia Autonomous Region, China, 2015–2024: An Epidemiologic Survey and Analysis
Major Causative Bacteria of Dairy Cow Mastitis in the Inner Mongolia Autonomous Region, China, 2015–2024: An Epidemiologic Survey and Analysis Open
In this study, we sought to evaluate the prevalence of bacterial pathogens of mastitis in dairy cattle in the Inner Mongolia Autonomous Region, China. The study was conducted from 2015 to 2024 using a total of 12,053 clinical mastitis (CM)…
View article: Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea
Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea Open
The risk prediction nomogram model of pyrotinib-induced severe diarrhea constructed in this study may identify high risk populations earlier so that clinicians can make appropriate decisions in time.
View article: Genetic stability of wild Rubus sachalinensis Léveillé cultivated using tissue culture and rapid propagation techniques examined with the ISSR-PCR system
Genetic stability of wild Rubus sachalinensis Léveillé cultivated using tissue culture and rapid propagation techniques examined with the ISSR-PCR system Open
View article: Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol
Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol Open
Introduction Lymphoedema is a distressing and long-term complication for breast cancer survivors. However, the reported incidence of lymphoedema varies, and its risk factors remain underexplored. Currently, a well-established risk predicti…
View article: Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients
Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients Open
Background Histologically, our understanding of intestinal polyps remains limited in scope, particularly regardingthe diverse subtypes observed in pediatric patients. To enhance our comprehension, three different polyp subtypes including s…
View article: Preoperative inter-arm differences and normative-based thresholds for lymphedema in Chinese breast cancer patients: Insights from a large cohort study
Preoperative inter-arm differences and normative-based thresholds for lymphedema in Chinese breast cancer patients: Insights from a large cohort study Open
View article: Omadacycline in the treatment of scrub typhus: Three case reports
Omadacycline in the treatment of scrub typhus: Three case reports Open
BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi (O. tsutsugamushi) . Omadacycline, a novel tetracyclin…
View article: Study protocol for evaluating the efficacy of early pulmonary rehabilitation combined with an internet-based patient management model in patients with COPD: a practical, multicentre, randomised controlled study from China
Study protocol for evaluating the efficacy of early pulmonary rehabilitation combined with an internet-based patient management model in patients with COPD: a practical, multicentre, randomised controlled study from China Open
Background COPD, a preventable and treatable disease, is characterised by persistent respiratory symptoms and airflow limitations, with high incidence, disability, mortality and disease burden. Currently, drug treatments mainly include bro…
View article: Visible-Light Photochromic Properties of an Inorganic-Organic Phosphomolybdic Acid/Polythiophene Hybrid Thin Film
Visible-Light Photochromic Properties of an Inorganic-Organic Phosphomolybdic Acid/Polythiophene Hybrid Thin Film Open
A visible-light photochromic hybrid film was synthesized based on combining phosphomolybdic acid (PMoA) with the polythiophene (PTh) matrix. The microstructure and photochromic properties of the materials were analyzed through atomic force…
View article: Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children
Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children Open
Background The understanding of the heterogeneous cellular microenvironment of colonic polyps in paediatric patients with solitary juvenile polyps (SJPs), polyposis syndrome (PJS) and Peutz–Jeghers syndrome (PJS) remains limited. Methods W…
View article: Isolation and identification of type 1d CP bovine viral diarrhea virus from Inner Mongolia, China
Isolation and identification of type 1d CP bovine viral diarrhea virus from Inner Mongolia, China Open
Background In recent years, outbreaks of respiratory and gastrointestinal diseases in cattle is associated with bovine viral diarrhea virus (BVDV). BVDV infection is a persistent global issue, particularly concerning for calves health. Com…
View article: Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic or surgical resection of esophageal carcinoma: a systematic review and meta-analysis
Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic or surgical resection of esophageal carcinoma: a systematic review and meta-analysis Open
Background early-stage esophageal carcinoma (EC) patients lack typical clinical signs and symptoms and are often diagnosed and treated at a late stage, leading to a poor prognosis and a high incidence of metachronous esophageal squamous ce…
View article: [Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease].
[Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease]. Open
Vitamin D can not only regulate calcium and phosphorus metabolism, but also exert an immunoregulatory effect. Vitamin D deficiency is common in patients with Crohn's disease (CD). Studies have shown that vitamin D is associated with CD and…
View article: [Nutritional status and its influencing factors in children with newly diagnosed inflammatory bowel disease].
[Nutritional status and its influencing factors in children with newly diagnosed inflammatory bowel disease]. Open
Children with newly diagnosed IBD have poor nutritional status, and the rates of anemia, emaciation, and growth retardation are high. Diagnostic delay is associated with malnutrition in children with IBD.
View article: Fluorene Thiophene α-Cyanostilbene Hexacatenar-Generating LCs with Hexagonal Columnar Phases and Gels with Helical Morphologies as Well as a Light-Emitting LC Display
Fluorene Thiophene α-Cyanostilbene Hexacatenar-Generating LCs with Hexagonal Columnar Phases and Gels with Helical Morphologies as Well as a Light-Emitting LC Display Open
Two series of novel synthesized hexacatenars, O/n and M/n, containing two thiophene-cyanostilbene units interconnected by central fluorene units (fluorenone or dicyanovinyl fluorene) using a donor–acceptor–acceptor–donor (A–D–A–D–A) rigid …
View article: Developing TCM clinical practice guidelines: A comparison between traditional Chinese medicine and western medicine
Developing TCM clinical practice guidelines: A comparison between traditional Chinese medicine and western medicine Open
Clinical practice guidelines in Traditional Chinese Medicine (CPG-TCM) is the recommendation that aims to provide the best service to users by identifying and summarizing the rules of prevention, diagnosis, treatment, rehabilitation, and r…
View article: Environmental geochemical characteristics of selenium in Northeastern China 1
Environmental geochemical characteristics of selenium in Northeastern China 1 Open
Keshan Disease (KD) is still a serious endemic public health problem in Northeast China. Previous studies have mainly focused on soil selenium content, staple food selenium content, and human selenium level, but there are few systematic st…
View article: Supplementary Methods from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Supplementary Methods from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
PDF file - 179K, Includes HEPA analysis data, Calculation of DP score, and supplementary references
View article: Supplementary Table 4 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Supplementary Table 4 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
PDF file - 98K, The detailed information and RT-PCR validation results for the TSA candidates nominated by HEPA analysis
View article: Supplementary Table 3 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Supplementary Table 3 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
PDF file - 104K, Literature references reporting the clinical applications of known TSAs and the top 100 genes nominated by HEPA analysis
View article: Supplementary Table 2 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Supplementary Table 2 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
PDF file - 41K, The weights for normal adult somatic tissues for the calculation of Depreciatory Penalty score
View article: Data from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Data from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
Tumor-specific antigens (TSA) are central elements in the immune control of cancers. To systematically explore the TSA genome, we developed a computational technology called heterogeneous expression profile analysis (HEPA), which can ident…
View article: Supplementary Table 3 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Supplementary Table 3 from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
PDF file - 104K, Literature references reporting the clinical applications of known TSAs and the top 100 genes nominated by HEPA analysis
View article: Data from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Data from An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer Open
Tumor-specific antigens (TSA) are central elements in the immune control of cancers. To systematically explore the TSA genome, we developed a computational technology called heterogeneous expression profile analysis (HEPA), which can ident…