Hongqiang Qin
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View article: In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking
In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking Open
Cyclic peptides represent a very useful modality in modern drug discovery. However, there remain substantial technical challenges in the de novo biosynthesis of complex cyclic peptides particularly in an intracellular manner. Herein, we de…
View article: Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification
Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification Open
Glycosylation changes are closely related to various diseases, including cancer. The quantitative analysis of site-specific glycans at proteomics scale remains challenging due to low glycopeptide spectra interpretation. Here, we present Gl…
View article: Site‐Selectively Accelerating the Generation of β‐Linked Residue Isoaspartate in Proteins
Site‐Selectively Accelerating the Generation of β‐Linked Residue Isoaspartate in Proteins Open
Isoaspartate (isoAsp) is a β‐linked residue in proteins spontaneously generated through Asn deamidation or Asp dehydration and significantly affects protein properties. However, the sluggish and site‐nonselective generation of isoAsp resid…
View article: Site‐Selectively Accelerating the Generation of β‐Linked Residue Isoaspartate in Proteins
Site‐Selectively Accelerating the Generation of β‐Linked Residue Isoaspartate in Proteins Open
Isoaspartate (isoAsp) is a β‐linked residue in proteins spontaneously generated through Asn deamidation or Asp dehydration and significantly affects protein properties. However, the sluggish and site‐nonselective generation of isoAsp resid…
View article: GP-Plotter: Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis
GP-Plotter: Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis Open
Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis. The visualization of fragment ions in mass spectrum provides strong evidence for peptide identification and modific…
View article: Robust Glycoproteomics Platform Reveals a Tetra‐Antennary Site‐Specific Glycan Capping with Sialyl‐Lewis Antigen for Early Detection of Gastric Cancer
Robust Glycoproteomics Platform Reveals a Tetra‐Antennary Site‐Specific Glycan Capping with Sialyl‐Lewis Antigen for Early Detection of Gastric Cancer Open
The lack of efficient biomarkers for the early detection of gastric cancer (GC) contributes to its high mortality rate, so it is crucial to discover novel diagnostic targets for GC. Recent studies have implicated the potential of site‐spec…
View article: The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma
The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma Open
View article: Advances in applications of activity-based chemical probes in the characterization of amino acid reactivities
Advances in applications of activity-based chemical probes in the characterization of amino acid reactivities Open
The discovery of novel drug targets enhances the development of novel drugs, and the discovery of novel target proteins depends on highly accurate high-throughput methods of analyzing drug-protein interactions. Protein expression levels, s…
View article: VLDLR disturbs quiescence of breast cancer stem cells in a ligand-independent function
VLDLR disturbs quiescence of breast cancer stem cells in a ligand-independent function Open
Breast cancer stem cells are responsible for cancer initiation, progression, and drug resistance. However, effective targeting strategies against the cell subpopulation are still limited. Here, we unveil two splice variants of very-low-den…
View article: Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer Open
Immunotherapy has been widely utilized in multiple tumors, however, its efficacy in the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms of RNA binding proteins in regulating…
View article: Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation
Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation Open
View article: Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression Open
Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded within the third intr…
View article: Additional file 3 of Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
Additional file 3 of Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression Open
Additional file 3.
View article: Recent advances in glycopeptide enrichment and mass spectrometry data interpretation approaches for glycoproteomics analyses
Recent advances in glycopeptide enrichment and mass spectrometry data interpretation approaches for glycoproteomics analyses Open
Protein glycosylation is one of the most important post-translational modifications (PTMs). The glycosylation is crucial in a variety of physiological and pathological processes that include protein stability, intracellular and intercellul…
View article: Diverse protein manipulations with genetically encoded glutamic acid benzyl ester
Diverse protein manipulations with genetically encoded glutamic acid benzyl ester Open
Herein, we genetically encode an esterified glutamic acid analogue (BnE) into proteins, and demonstrate that BnE can be applied in different types of site-specific protein modifications.
View article: Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer
Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer Open
Multi-drug resistance (MDR) remains a great obstacle to effective chemotherapy for gastric cancer. A number of secreted glycoproteins have been reported to be involved in the development of MDR in gastric cancer. However, whether glycosyla…
View article: A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method
A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method Open
Enrichment of glycopeptides by hydrazide chemistry (HC) is a popular method for glycoproteomics analysis. However, possible side reactions of peptide backbones during the glycan oxidation in this method have not been comprehensively studie…