Hongqiu Gu
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View article: Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry
Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry Open
Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Strok…
View article: Alteplase treatment in patients with minor ischemic stroke: a nationwide registry analysis
Alteplase treatment in patients with minor ischemic stroke: a nationwide registry analysis Open
This study was supported by grants from the National Natural Science Foundation of China (81870905, U20A20358) and from Beijing Hospitals Authority (QML20210501, PX2021024).
View article: Global trends in recombinant human growth hormone for the treatment of idiopathic short stature: a bibliometric analysis
Global trends in recombinant human growth hormone for the treatment of idiopathic short stature: a bibliometric analysis Open
Background The treatment of idiopathic short stature (ISS) with recombinant human growth hormone (rhGH) has been a subject of extensive research. This study aims to perform a bibliometric analysis of publications related to rhGH treatment …
View article: Lactate metabolic reprogramming and histone lactylation modification in sepsis
Lactate metabolic reprogramming and histone lactylation modification in sepsis Open
Sepsis, a serious condition characterized by life-threatening organ dysfunction owing to infection, lacks specific therapeutic interventions. Lactate serves as a crucial biomarker in sepsis, reflecting both the patient's metabolic state an…
View article: Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial
Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial Open
National Key R&D Program of China, National Natural Science Foundation of China, the Capital's Funds for Health Improvement and Research and Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences. China Kunming Pharmaceut…
View article: Inappropriate dosing of direct oral anticoagulants among very older inpatients with atrial fibrillation
Inappropriate dosing of direct oral anticoagulants among very older inpatients with atrial fibrillation Open
View article: Association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease and hepatic steatosis in United States adults: insights from NHANES 2017–2020
Association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease and hepatic steatosis in United States adults: insights from NHANES 2017–2020 Open
Objective This study aimed to investigate the association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and NAFLD, as well as its relationship with hepatic steatosis and liver fib…
View article: Prevalence, Awareness, Treatment, and Control of Diabetes Among 0.98 Million Patients With Stroke/<scp>TIA</scp> in China: Insights From a Nationwide Cohort Study
Prevalence, Awareness, Treatment, and Control of Diabetes Among 0.98 Million Patients With Stroke/<span>TIA</span> in China: Insights From a Nationwide Cohort Study Open
Background A comprehensive epidemiological investigation of the coexistence between diabetes and stroke/TIA in China is urged. Methods Data from the Chinese Stroke Center Alliance program, a nationwide multi‐center registry study, were use…
View article: Heart Failure Is Associated With Increased Stroke Severity, In‐Hospital Mortality, Major Adverse Cardiovascular Events, and Complications: Insights From the Chinese Stroke Center Alliance
Heart Failure Is Associated With Increased Stroke Severity, In‐Hospital Mortality, Major Adverse Cardiovascular Events, and Complications: Insights From the Chinese Stroke Center Alliance Open
Background Heart failure (HF) constitutes the source of various damaging pathophysiological mechanisms in acute ischemic stroke (AIS). The effect of a previous HF on the in‐hospital outcomes for patients with AIS still lacks effective rese…
View article: Outcomes of Time to Treatment With Reteplase for Acute Ischemic Stroke
Outcomes of Time to Treatment With Reteplase for Acute Ischemic Stroke Open
View article: Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024
Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024 Open
Background Stroke remains a major global health challenge, with China experiencing a significant burden due to its high incidence and severe outcomes. Reperfusion therapies, such as intravenous thrombolysis and endovascular thrombectomy, h…
View article: Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial
Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial Open
View article: Edaravone Dexborneol vs Placebo on Functional Outcomes in Patients with Acute Ischaemic Stroke Who Underwent Endovascular Thrombectomy (Taste-2): A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial
Edaravone Dexborneol vs Placebo on Functional Outcomes in Patients with Acute Ischaemic Stroke Who Underwent Endovascular Thrombectomy (Taste-2): A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Open
View article: Association of C-Reactive Protein with Short-Term Outcomes in Spontaneous Intracerebral Hemorrhage Patients with or without Infection: From a Large-Scale Nationwide Longitudinal Registry
Association of C-Reactive Protein with Short-Term Outcomes in Spontaneous Intracerebral Hemorrhage Patients with or without Infection: From a Large-Scale Nationwide Longitudinal Registry Open
A significantly increased CRP level was associated with a higher risk of early functional disability and hematoma evacuation in patients with ICH, regardless of the presence or absence of infectious complications. Infection may increase th…
View article: SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials
SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials Open
This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang’s Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed t…
View article: Impact of Clonal Hematopoiesis of Indeterminate Potential on the Long-Term Risk of Recurrent Stroke in Patients with a High Atherosclerotic Burden
Impact of Clonal Hematopoiesis of Indeterminate Potential on the Long-Term Risk of Recurrent Stroke in Patients with a High Atherosclerotic Burden Open
Our results revealed that CHIP might have a significant impact on the long-term risk of recurrent stroke, particularly in patients with a higher atherosclerotic burden.
View article: Inappropriate Dosing of Direct Oral Anticoagulants Among Very Elderly Inpatients With Atrial Fibrillation
Inappropriate Dosing of Direct Oral Anticoagulants Among Very Elderly Inpatients With Atrial Fibrillation Open
Background: Among very elderly patients with atrial fibrillation, the frequency of inappropriate direct oral anticoagulant (DOAC) dosing, associated factors, and temporal trends in practice are unknown. Objective: To investigate the freque…
View article: Characteristics, temporal trends and outcomes of intravenous thrombolysis in Chinese patients aged>80 years who had a stroke
Characteristics, temporal trends and outcomes of intravenous thrombolysis in Chinese patients aged>80 years who had a stroke Open
Background and purpose To date, no large cohort study has investigated the effects of intravenous thrombolysis (IVT) in Chinese patients aged over 80 years who had a stroke. This study aimed to assess the trends in the use of alteplase, th…
View article: Preexisting Heart Disease Spectrum and In‐Hospital Outcomes for Patients With Acute Ischemic Stroke
Preexisting Heart Disease Spectrum and In‐Hospital Outcomes for Patients With Acute Ischemic Stroke Open
Background Although many studies have examined the influence of individual preexisting heart conditions on stroke outcomes, the combined effects of these conditions remain understudied. Methods The data supporting this study's findings are…
View article: Construction of Interlocking Ethnic Communities Under the Theory of Actor Network: A Practical Approach of Honghe Town in Jiaxing City
Construction of Interlocking Ethnic Communities Under the Theory of Actor Network: A Practical Approach of Honghe Town in Jiaxing City Open
With the phenomenon of multi-ethnic cohabitation becoming more and more common, how to effectively promote the communication and integration between different ethnic groups to achieve national unity and common prosperity has become an impo…
View article: Association between PPAR<b>γ</b> polymorphisms and neurological functional disability of ischemic stroke
Association between PPAR<b>γ</b> polymorphisms and neurological functional disability of ischemic stroke Open
Peroxisome proliferator-activated receptor-γ ( PPARγ) plays a protective role against brain injury after stroke in mice. However, the relationship between PPARγ gene polymorphisms and the functional outcome of acute ischemic stroke (AIS) r…
View article: DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke
DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke Open
Somatic mutations related to clonal hematopoiesis of indeterminate potential (CHIP) are risk factors for stroke. The impact of DNMT3A , the most mutated gene in CHIP, on clinical functional outcomes of acute ischemic stroke (AIS) remains u…
View article: Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial
Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial Open
Objectives To assess the efficacy and safety of colchicine versus placebo on reducing the risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient ischaemic attack within the first three months of symptom o…
View article: Data‐Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study
Data‐Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study Open
Background We aim to identify the distinct lesion patterns and regions associated with functional outcome and inflammation in patients with acute ischemic stroke, and investigate whether the association between lesion patterns and function…
View article: Gait speed at the acute phase predicted health-related quality of life at 3 and 12 months after stroke: a prospective cohort study
Gait speed at the acute phase predicted health-related quality of life at 3 and 12 months after stroke: a prospective cohort study Open
Objective: To investigate the association between acute-phase gait speed and health-related quality of life (HRQoL) at 3 and 12 months post-stroke. Design: Prospective cohort study. Subjects/Patients: 1,475 patients with first-ever ischaem…
View article: Comparison of stress hyperglycemia ratio and glycemic gap on acute <scp>ICH</scp> in‐hospital outcomes
Comparison of stress hyperglycemia ratio and glycemic gap on acute <span>ICH</span> in‐hospital outcomes Open
Objective To compare the effect of different indicators on stress‐induced hyperglycemia for predicting in‐hospital outcomes of acute intracerebral hemorrhage. Methods Using data from the Chinese Stroke Center Alliance database, which is a …
View article: Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial
Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial Open
Background Edaravone dexborneol is believed to be a novel cytoprotective drug, demonstrating a synergistic combination of antioxidative and anti-inflammatory properties in animal models. The Treatment of Acute Ischaemic Stroke with Edaravo…
View article: Inflammatory marker profiles and in‐hospital neurological deterioration in patients with acute minor ischemic stroke
Inflammatory marker profiles and in‐hospital neurological deterioration in patients with acute minor ischemic stroke Open
Aim The aim of the study was to analyze the association between inflammatory marker profiles and in‐hospital neurological deterioration (ND) in acute ischemic stroke (AIS) patients. Methods Data from patients with minor AIS from the Third …
View article: Assessment of rehabilitation following acute ischaemic stroke in China: a registry-based retrospective observational study
Assessment of rehabilitation following acute ischaemic stroke in China: a registry-based retrospective observational study Open
Objectives This study aimed to describe the frequency, determinants and outcomes for assessment of patients who had an acute ischaemic stroke (AIS) for rehabilitation during hospitalisation in China. Design A registry-based retrospective o…
View article: Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance
Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance Open