Explanipedia

Data-driven discovery of antiviral peptides against PRRSV using multiple machine learning models Open

Wafa Yousaf, Abdul Haseeb, Y. P. Shen, Hongquan Li, Kuohai Fan , et al. · 2025

Introduction Cellular machinery is built upon proteins and their functional interrelationships. Their network evaluation is essential for a comprehensive insight into biological processes and may establish a foundation for predicting antiv…

Ice gliding diatoms establish record-low temperature limits for motility in a eukaryotic cell Open

Qing Zhang, Hope T. Leng, Hongquan Li, Kevin R. Arrigo, Manu Prakash · 2025

Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with l…

Potential mechanisms of zinc sulfate in inhibiting porcine reproductive and respiratory syndrome virus replication: attenuation of oxidative stress, inflammatory response, and apoptosis Open

Huizhen Yang, C. Zhang, Qianfan Li, Zixuan Wu, Na Sun , et al. · 2025

Introduction This study aimed to elucidate the mechanism of zinc sulfate against porcine reproductive and respiratory syndrome virus (PRRSV) through transcriptomic data and experimental validation. Methods Initially, the expression of PRRS…

Parvoviruses NS1 oncolytic attributes: mechanistic insights and synergistic anti-tumor therapeutic strategies Open

Abdul Haseeb, Wafa Yousaf, Zhigang Cao, Kuohai Fan, Nian X. Sun , et al. · 2025

Parvovirus is comprised of a single-stranded DNA structure, encompassing distinct structural and non-structural proteins. Structural proteins are referred as viral proteins, which facilitate for the viral capsid. Among non-structural prote…

Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets Open

Zhigang Cao, Yalin Wu, Xiangming Cong, Abdul Haseeb, Panpan Sun , et al. · 2025

Introduction Previous studies have suggested that matrine may improve animal production performance, but its role and underlying mechanisms remain unclear. Methods Following the determination of the LD 50 of matrine in ICR mice, the long-t…

Porcine Recombinant NK-Lysin Inhibits the Growth and Metastasis of Murine Hepatocellular Carcinoma In Vivo Open

Kuohai Fan, Zhiwei Feng, Dahai Zhao, Xiaozhong Zheng, Wei Yin , et al. · 2025

Porcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on the proliferation and metastasis of HCC cells in vivo remain unc…

Assay of cardiopulmonary bypass system for porcine alveolar macrophages removing GFP-<i>E. coli</i> from erythrocyte surfaces Open

Yongqiang Liu, Nan Wang, Qing Ru, Kuohai Fan, Na Sun , et al. · 2025

While it is established that complement receptor molecules on the surface of erythrocytes are crucial for the clearance of immune complexes in the body, the molecular mechanisms underlying the interaction between macrophages and erythrocyt…

The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics Open

Sihuan Zhang, Hongquan Li, Xuzhen Wang, Panpan Sun, Huaping Zhang , et al. · 2025

Porcine circovirus type 2 (PCV2) is highly prevalent in nature and serves as the primary pathogen responsible for porcine circovirus-associated disease (PCVD/PCVAD), posing a significant threat to pig production. Currently, vaccination alo…

Ice gliding diatoms establish record-low temperature limit for motility in a eukaryotic cell Open

Qing Zhang, Hope T. Leng, Hongquan Li, Kevin R. Arrigo, Manu Prakash · 2024

Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with l…

Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model Open

Hong Wang, Na Sun, Panpan Sun, Hua Zhang, Wei Yin , et al. · 2024

Introduction Porcine circovirus type 2 (PCV2) is an important pathogen that causes diarrhea in nursery and fattening pigs, resulting in huge economic losses for commercial pig farms. Protective efficacy of vaccines is compromised by mutati…

Porcine Recombinant Nk-Lysin Inhibits the Growth and Metastasis of Hepatocellular Carcinoma In Vivo Open

Kuohai Fan, Zhiwei Feng, Dahai Zhao, Jianhua Guo, Xiaozhong Zheng , et al. · 2024

Porcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on the proliferation and metastasis of HCC cells in vivo remain unc…

A genetic and microscopy toolkit for manipulating and monitoring regeneration in Macrostomum lignano Open

Richard Nelson Hall, Hongquan Li, Chew Chai, Sidney Y. Vermeulen, Robin R Bigasin , et al. · 2024

Construction and Immunogenicity of Recombinant Lactococcus Lactis Expressing CTB-Cap Fusion Protein Open

Kuohai Fan, Lele Cui, Yina An, Jianhua Guo, Wei Yin , et al. · 2024

This study aims to investigate the immunogenicity of recombinant Lactococcus Lactis (rL. lactis) that expressed Cholera Toxin B Subunit (CTB) and PCV2 capsid protein (Cap) fusion protein. The rL. Lactis expressed CTB-Cap fusion protein was…

Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway Open

Zhongda Cao, Nannan Ma, Maoyang Shan, Shiyan Wang, Jige Du , et al. · 2024

Feline infectious peritonitis (FIP), a serious infectious disease in cats, has become a challenging problem for pet owners and the industry due to the lack of effective vaccinations and medications for prevention and treatment. Currently, …

Analysis of the anti-PCV2 mechanism of Lactobacillus acidophilus based on non-target metabolomics and high-throughput molecular docking Open

Zhigang Cao, Xiaoya Ling, Abdul Haseeb, Panpan Sun, Hua Zhang , et al. · 2024

Our previous studies have revealed that L. acidophilus possesses inhibitory effects on PCV2 proliferation in vivo , although the underlying mechanisms remain elusive. Probiotics like L. acidophilus are known to exert antiviral through thei…

Fascin-1 Promotes Cell Metastasis through Epithelial–Mesenchymal Transition in Canine Mammary Tumor Cell Lines Open

Xin Wang, Ye Zhou, Linhao Wang, Abdul Haseeb, Hongquan Li , et al. · 2024

Canine mammary tumors (CMTs) are the most common type of tumor in female dogs. In this study, we obtained a metastatic key protein, Fascin-1, by comparing the proteomics data of in situ tumor and metastatic cell lines from the same individ…

Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens Open

Shuangxiu Wan, Linzheng Wang, Zhili Hao, Lin Zhu, Xiaoxia Mao , et al. · 2024

The deoxynivalenol (DON)-contaminated feeds can impair chicken gut barrier function, disturb the balance of the intestinal microbiota, decrease chicken growth performance and cause major economic loss. With the aim of investigating the ame…

Dietary supplementation of osthole and icariin improves the production performance of laying hens by promoting follicular development Open

Wenwen Ding, Linhui Shangguan, Hongquan Li, Yinghui Bao, Fida Noor , et al. · 2024

Osthole (Ost) and icariin (Ica) are extracted from traditional Chinese medicine Cnidium monnieri and Epimedii Folium, respectively, and both exhibit estrogen-like biological activity. This study aimed to determine the efficacy and safety o…

Metal Binding Feature of Copper-Induced Metallothionein from Fresh Water Crab Sinopotamon Henanense Reveals its Cu-Thionein Character Open

Huizhen Yang, Zixuan Wu, Xiaojiao Li, Hongquan Li, Lan Wang · 2024

Matrine Targets BTF3 to Inhibit the Growth of Canine Mammary Tumor Cells Open

Zijian Feng, Na Sun, Fida Noor, Panpan Sun, Hua Zhang , et al. · 2023

The canine mammary tumor model is more suitable for studying human breast cancer, and the safety concentrations of matrine and the biotin-labeled matrine probe were determined in canine primary mammary epithelial cells, and then selected c…

Fascin-1 re-expression promotes cell metastasis through epithelial-mesenchymal transition in canine mammary tumour CHMm cell Open

Xin Wang, Ye Zhou, Abdul Haseeb, Hongquan Li, Xiaozhong Zheng , et al. · 2023

Background Canine mammary tumour (CMT) is the most common tumour disease in female dogs. At the same time, the popular concept of preferring purebred dogs when choosing pets has affected the incidence of mammary tumours in dogs. In this st…

Scutellarin targets Wnt5a against zearalenone-induced apoptosis in mouse granulosa cells in vitro and in vivo Open

Na Sun, Abdul Haseeb, Panpan Sun, Hua Zhang, Jia Zhong , et al. · 2023

Zearalenone (ZEA) poses severe reproductive toxicity to both humans and animals. Scutellarin has been demonstrated to rescue ZEA-induced apoptosis in mouse ovarian granulosa cells (GCs), but its specific targets remain unclear. In the pres…

Matrine Targets Intestinal Lactobacillus acidophilus to Inhibit Porcine Circovirus Type 2 Infection in Mice Open

Zhigang Cao, Xiaoya Ling, Panpan Sun, Xiaozhong Zheng, Hua Zhang , et al. · 2023

Porcine circovirus type 2 (PCV2) has caused huge economic losses to the pig industry across the world. Matrine is a natural compound that has been shown to regulate intestinal flora and has anti-PCV2 activity in mouse models. PCV2 infectio…

Target Discovery of Matrine against PRRSV in Marc-145 Cells via Activity-Based Protein Profiling Open

Xiaoya Ling, Zhigang Cao, Panpan Sun, Hua Zhang, Yaogui Sun , et al. · 2023

Porcine reproductive and respiratory syndrome (PRRS) seriously endangers the sustainable development of the pig industry. Our previous studies have shown that matrine can resist porcine reproductive and respiratory syndrome virus (PRRSV) i…

Lightweight aerial image object detection algorithm based on improved YOLOv5s Open

Lixia Deng, Lingyun Bi, Hongquan Li, Haonan Chen, Xuehu Duan , et al. · 2023

YOLOv5 is one of the most popular object detection algorithms, which is divided into multiple series according to the control of network depth and width. To realize the deployment of mobile devices or embedded devices, the paper proposes a…

Network pharmacology and experimental validation to reveal the target of matrine against PRRSV Open

Yaxiang Zhao, Xiaoya Ling, Hua Zhang, Panpan Sun, Yaogui Sun , et al. · 2023

Porcine reproductive and respiratory syndrome (PRRS) is an epidemic animal infectious disease worldwide. In our previous research it was suggested that matrine could inhibit PRRSV infection both in vitro and in vivo, but the …

Molecular Simulation Study on the Interaction between Porcine CR1-like and C3b Open

Zhen Hou, Wei Yin, Zhili Hao, Kuohai Fan, Na Sun , et al. · 2023

The molecular basis of porcine red blood cell immune adhesion function stems from the complement receptor type 1-like (CR1-like) on its cell membrane. The ligand for CR1-like is C3b, which is produced by the cleavage of complement C3; howe…

Matrine combined with Osthole inhibited the PERK apoptosis of splenic lymphocytes in PCV2-infected mice model Open

Yinlan Xu, Shuangxiu Wan, Panpan Sun, Ajab Khan, Jianhua Guo , et al. · 2023

Metal Binding Feature Of Copper-Induced Metallothionein from Fresh Water Crab Sinopotamon Henanense Reveals its Cu-Thionein Character Open

Huizhen Yang, Zixuan Wu, Xiaojiao Li, Hongquan Li, Lan Wang · 2023

Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs Open

Jiangang Zheng, Panpan Sun, Na Sun, Zhili Hao, Kuohai Fan , et al. · 2022

Background Zedoary turmeric oil extracted from the roots of curcuma ( Curcuma aeruginosa Roxb.) is used for the treatment of myocarditis in China. EMCV infection causes abortion in pregnant sows and myocarditis in piglets. Our previous stu…

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