Hua Jiang
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View article: <scp>CircANKRD52</scp> Augments the Growth and Invasion of Melanoma Cells by Sponging <scp>miR</scp> ‐141‐3p and Upregulating <scp>PRKACB</scp>
<span>CircANKRD52</span> Augments the Growth and Invasion of Melanoma Cells by Sponging <span>miR</span> ‐141‐3p and Upregulating <span>PRKACB</span> Open
Accumulating data have shown that circRNAs act pivotal roles in cancer progression. However, the role and molecular mechanism of circRNAs in melanoma remain undocumented. GEO dataset was used to identify the differentially expressed circRN…
View article: Wedelolactone induces pyroptosis to suppress retinoblastoma by inhibiting the Nrf2/Keap1 signaling pathway
Wedelolactone induces pyroptosis to suppress retinoblastoma by inhibiting the Nrf2/Keap1 signaling pathway Open
View article: A Multicenter Study of Acute Abdomen in Children With Acute Lymphoblastic Leukemia: <scp>CCCG</scp>‐<scp>ALL</scp>‐2015
A Multicenter Study of Acute Abdomen in Children With Acute Lymphoblastic Leukemia: <span>CCCG</span>‐<span>ALL</span>‐2015 Open
Objective Acute abdomen presents a significant challenge in the treatment of childhood acute lymphoblastic leukemia (ALL), potentially leading to treatment failure and treatment‐related mortality. Results from the multicenter study of CCCG…
View article: Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease
Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease Open
Alzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is i…
View article: Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation Open
Allogeneic stem cell transplantation (allo-HSCT) cures pediatric blood disorders, but graft-versus-host disease (GVHD) remains a major complication. This study investigated the link between gut microbiota and GVHD in 118 pediatric allo-HSC…
View article: Pre-treatment peripheral blood TCR repertoire as a predictor of response in patients with NSCLC treated with immunochemotherapy
Pre-treatment peripheral blood TCR repertoire as a predictor of response in patients with NSCLC treated with immunochemotherapy Open
View article: CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer
CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with no current effective treatment options. Chimeric antigen receptor (CAR) T cell therapy represents a powerful immunotherapeutic approach but faces maj…
View article: Corrigendum: Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease
Corrigendum: Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease Open
[This corrects the article DOI: 10.3389/fmicb.2024.1528258.].
View article: Bone marrow mesenchymal stroma cell serves as a harbor anchoring acute B lymphoblastic leukemia cells
Bone marrow mesenchymal stroma cell serves as a harbor anchoring acute B lymphoblastic leukemia cells Open
View article: Petrogenesis of the Late Cretaceous Jiepailing Granitoids in South China: Implications for Sn Mineralization and Tectonic Evolution
Petrogenesis of the Late Cretaceous Jiepailing Granitoids in South China: Implications for Sn Mineralization and Tectonic Evolution Open
The Late Cretaceous Jiepailing granitoids, located at the central Nanling Range in South China, are closely associated with significant Sn‐Li‐Be‐F polymetallic metallogeny. The Jiepailing granitoids mainly consist of granitic porphyry and …
View article: Strategies to Overcome Antigen Heterogeneity in CAR-T Cell Therapy
Strategies to Overcome Antigen Heterogeneity in CAR-T Cell Therapy Open
Chimeric antigen receptor (CAR) gene-modified T-cell therapy has achieved significant success in the treatment of hematological malignancies. However, this therapy has not yet made breakthroughs in the treatment of solid tumors and still f…
View article: Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma
Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma Open
Small cell neuroendocrine cervical carcinoma (SCNECC) is an aggressive gynecological malignancy with poor prognosis. The precision therapeutic strategies for SCNECC are severely limited by the complex tumor microenvironment. Here, we mappe…
View article: Association Between Systemic Immune-Inflammation Index and Stress Urinary Incontinence in Adult Women: A Population-Based Study
Association Between Systemic Immune-Inflammation Index and Stress Urinary Incontinence in Adult Women: A Population-Based Study Open
Our findings suggest an association between elevated SII levels and an increased likelihood of SUI in women. Further well-designed prospective studies are needed to substantiate our results.
View article: Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling
Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling Open
Background The increased incidence of androgenic alopecia (AGA) causes adverse physiological and psychological effects on people of all genders. The hair follicle stem cells (HFSCs) have displayed clinical improvements on AGA. However, the…
View article: Meta-analysis of minimally invasive transforaminal lumbar interbody fusion versus oblique lumbar interbody fusion for treating lumbar degenerative diseases
Meta-analysis of minimally invasive transforaminal lumbar interbody fusion versus oblique lumbar interbody fusion for treating lumbar degenerative diseases Open
Compared to MIS-TLIF, OLIF is associated with a shorter operative time and less intraoperative blood loss, potentially leading to better relief of leg pain, restoration of DH, and prevention of subsidence. These findings offer valuable ins…
View article: Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease
Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease Open
Background/aim The purpose of this study was to examine the hepatic bacterial composition and metabolome characteristics of patients with NAFLD using 16S rDNA sequencing and metabolomics. The results of the study revealed substantial diffe…
View article: Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Observational Studies
Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Observational Studies Open
Background Leptomeningeal collateral status is a major determinant of outcomes in patients with acute ischemic stroke; however, the factors that determine collateral status are not well understood. We conducted a comprehensive systematic r…
View article: Novel regulator Fpr2 controls immune homeostasis via CCL4-dependent neutrophils
Novel regulator Fpr2 controls immune homeostasis via CCL4-dependent neutrophils Open
Polymorphonuclear leukocytes (PMNs) in Fpr2- deficient mice have significantly impaired bactericidal activity, yet the precise mechanism remains elusive. Our research unveiled the cellular heterogeneity of peripheral blood PMNs through sin…
View article: β-glucan combined with Envafolimab and Endostar as immune rechallenge for metastatic non-small cell lung cancer
β-glucan combined with Envafolimab and Endostar as immune rechallenge for metastatic non-small cell lung cancer Open
β-glucan combined with Envafolimab and Endostar has considerable efficacy and safety for immune rechallenge in metastatic NSCLC patients who failed of anti-PD-1 treatment previously, especially for PD-L1 positive patients.
View article: Unrelated umbilical cord blood transplantation using a noval conditioning regimen for small month-old infants with rare non-malignant disorders
Unrelated umbilical cord blood transplantation using a noval conditioning regimen for small month-old infants with rare non-malignant disorders Open
Background Patients afflicted with rare non-malignant disorders endure the pain of the disease from birth. Receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT), especially umbilical cord blood transplantation (UCBT), as…
View article: An exploratory clinical study of β-glucan combined with camrelizumab and SOX chemotherapy as first-line treatment for advanced gastric adenocarcinoma
An exploratory clinical study of β-glucan combined with camrelizumab and SOX chemotherapy as first-line treatment for advanced gastric adenocarcinoma Open
Background β-glucan has been reported to be a potential natural immune modulator for tumor growth inhibition. We aimed to evaluate the efficacy and safety of β-glucan plus immunotherapy and chemotherapy in the first-line treatment of advan…
View article: RETRACTED: Chronological effects of immune checkpoint inhibitors in non-small cell lung cancer
RETRACTED: Chronological effects of immune checkpoint inhibitors in non-small cell lung cancer Open
The authors have requested that this preprint be removed from Research Square.
View article: Comparison of upfront haploidentical hematopoietic stem cell transplantation and salvage haploidentical hematopoietic stem cell transplantation after immunosuppressive therapy in children with acquired severe aplastic anemia - a multicenter study
Comparison of upfront haploidentical hematopoietic stem cell transplantation and salvage haploidentical hematopoietic stem cell transplantation after immunosuppressive therapy in children with acquired severe aplastic anemia - a multicenter study Open
Background For children with severe aplastic anemia, if the first immunosuppressive therapy (IST) fails, it is not recommended to choose a second IST. Therefore, for patients without matched sibling donor (MSD) and matched unrelated donor …
View article: Outcome of infants with acute lymphoblastic leukemia treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia 2015 study protocol
Outcome of infants with acute lymphoblastic leukemia treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia 2015 study protocol Open
Not available.
View article: Association between Systemic Immune-Inflammation Index and stress urinary incontinence in adult women: a population-based study
Association between Systemic Immune-Inflammation Index and stress urinary incontinence in adult women: a population-based study Open
Background Systemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation may contribute significantly to the aetiology of stress urinary incontinence (SUI), in addition to recognised factors. The aim of this stu…
View article: Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies
Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies Open
X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder associated with mutations of the ABCD1 gene that encodes a peroxisomal transmembrane protein. It results in accumulation of very long chain fatty acids in tis…
View article: Evidence summary on managing radiotherapy-induced oral mucositis in patients with head and neck cancer
Evidence summary on managing radiotherapy-induced oral mucositis in patients with head and neck cancer Open
This study has been registered on the Fudan University Centre for Evidence-based Nursing. Registration No. is ES20232732.
View article: The fatty acid-related gene signature stratifies poor prognosis patients and characterizes TIME in cutaneous melanoma
The fatty acid-related gene signature stratifies poor prognosis patients and characterizes TIME in cutaneous melanoma Open
Background The aim of this study is to build a prognostic model for cutaneous melanoma (CM) using fatty acid-related genes and evaluate its capacity for predicting prognosis, identifying the tumor immune microenvironment (TIME) composition…
View article: Influence of enhanced external counterpulsation on endothelial function: a meta-analysis of randomized controlled trials
Influence of enhanced external counterpulsation on endothelial function: a meta-analysis of randomized controlled trials Open
EECP may be effective in improving endothelial function measured by FMD.
View article: CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer
CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer Open