Hongrui Zhu
YOU?
Author Swipe
View article: Small regulatory RNAs mediated regulation of virulence and host–pathogen interaction in the Gram-negative ESKAPE pathogens
Small regulatory RNAs mediated regulation of virulence and host–pathogen interaction in the Gram-negative ESKAPE pathogens Open
The emergence and global spread of antimicrobial resistant (AMR) pathogens represent a critical challenge to global public health security. The ESKAPE pathogens refer to a group of highly troublesome multidrug-resistant bacteria responsibl…
View article: Biocompatible decarboxylative coupling enabled by N-hydroxynaphthalimide esters
Biocompatible decarboxylative coupling enabled by N-hydroxynaphthalimide esters Open
This study develops a catalyst-free, light-induced decarboxylative coupling utilizing N-hydroxynaphthalimide esters (NHNI esters) as multifunctional reagents, acting as photosensitizers, oxidants, and redox-active esters. In cell lysates, …
View article: A comprehensive evidence-based intervention programme significantly reduces intensive care unit-acquired weakness and improves functional recovery: a retrospective analysis
A comprehensive evidence-based intervention programme significantly reduces intensive care unit-acquired weakness and improves functional recovery: a retrospective analysis Open
Background: Intensive care unit-acquired weakness (ICU-AW) affects 25–50% of critically ill patients, resulting in prolonged hospitalization and impaired functional recovery. Despite recognition of its clinical importance, effective preven…
View article: Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty
Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty Open
Fospropofol disodium may be a viable alternative in settings where injection pain and PONV are primary concerns, provided that hemodynamic stability is actively managed in elderly THA patients, with non-inferior efficacy in preventing PND …
View article: Knowledge attitude, and practice of patients with knee osteoarthritis towards perioperative functional exercise after total knee arthroplasty: a cross-sectional study
Knowledge attitude, and practice of patients with knee osteoarthritis towards perioperative functional exercise after total knee arthroplasty: a cross-sectional study Open
Background To investigate the knowledge, attitude, and practice (KAP) in patients with knee osteoarthritis (OA) towards perioperative functional exercise after total knee arthroplasty (TKA). Methods The cross-sectional survey enrolled knee…
View article: Enhanced remediation of actual dye wastewater by hydrogenated bimetallic MOF derivative with active peracetic acid
Enhanced remediation of actual dye wastewater by hydrogenated bimetallic MOF derivative with active peracetic acid Open
This study introduces a hydrogenated FeCo-MOF derivative catalyst (HC-FeCo@C350) to activate peracetic acid (PAA) for efficient degradation dye wastewater. Rhodamine B (RhB) as a model pollutant, the HC-FeCo@C350/PAA achieved a 99.33% remo…
View article: Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety
Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety Open
Post-stroke anxiety (PSA) manifests as anxiety symptoms after stroke, with unclear mechanisms and limited treatment strategies. Endocannabinoids, reported to mitigate fear, anxiety, and stress, undergo dynamic alterations after stroke link…
View article: Effects of Fospropofol Disodium and Propofol on the Postoperative Recovery of Elderly Patients Who Underwent Total Hip Arthroplasty: A Retrospective Study
Effects of Fospropofol Disodium and Propofol on the Postoperative Recovery of Elderly Patients Who Underwent Total Hip Arthroplasty: A Retrospective Study Open
Fospropofol disodium reduces the incidence of PONV in patients. And the effects of fospropofol disodium on postoperative recovery quality are similar to that of propofol in older patients who underwent total hip arthroplasty.
View article: Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation
Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation Open
CRF01_AE rapidly reduced CD4 count during the recent HIV infection. The CD4 count of the recently infected individuals with CRF01_AE increased sharply and reached its highest level of recovery within the first year of ART initiation. This …
View article: Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior
Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior Open
Post-stroke anxiety (PSA) seriously affects the prognosis of patients, which is an urgent clinical problem to be addressed. However, the pathological mechanism of PSA is largely unclear. Here, we found that neuronal HIPK2 expression was up…
View article: Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia
Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia Open
Sepsis is one of the leading causes of death in critical patients worldwide and its occurrence is related to the excessive activation of macrophages. Chloride loss worsens the prognosis of patients with sepsis but the underlying mechanism …
View article: Development and evaluation of a family-child reading picture book on reducing autism spectrum disorder caregivers’ psychological stress: a mixed method study
Development and evaluation of a family-child reading picture book on reducing autism spectrum disorder caregivers’ psychological stress: a mixed method study Open
Introduction The rapid increasing prevalence of ASD has become a significant global health issue. Caregivers of children with ASD are experiencing higher level of psychological stress and mental disorders. However, interventions to improve…
View article: Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia
Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia Open
Treatment of emergence agitation in adults with remifentanil infusion is more effective than propofol, with a shorter time to extubation and discharge from PACU.
View article: TurboID coupled with APEX2: Application prospects for deciphering proteome trafficking and interactions in neuroscience
TurboID coupled with APEX2: Application prospects for deciphering proteome trafficking and interactions in neuroscience Open
Proteins are often secreted and transited through cells or multiple organelles in physiological and pathological processes. Various interacting proteins are highly dynamic. Many proteins transiently interact with adjacent proteins with low…
View article: HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway
HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway Open
Background: The inflammation and immune response contribute to ischemic stroke pathology. Damaged brain cells release inflammatory substances to activate the immune system in the acute phase of stroke, including altering the interferon sig…
View article: Noteworthy perspectives on microglia in neuropsychiatric disorders
Noteworthy perspectives on microglia in neuropsychiatric disorders Open
Microglia are so versatile that they not only provide immune surveillance for central nervous system, but participate in neural circuitry development, brain blood vessels formation, blood–brain barrier architecture, and intriguingly, the r…
View article: Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer’s disease
Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer’s disease Open
Summary The pathology of Alzheimer’s disease (AD) is associated with the extracellular amyloid-β (Aβ) plaques that perturb the mechanical properties of brain tissue. Microglia sense and integrate biochemical cues in their local microenviro…
View article: HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy
HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy Open
Background Phobic anxiety present after stroke (called poststroke anxiety, PSA) can hamper the rehabilitation of patients and disrupt their usual activities. Besides, the symptoms and mechanisms of PSA are different from those in nonstroke…
View article: Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits Open
Structural variations of the human brain are heritable and highly polygenic traits, with hundreds of associated genes identified in recent genome-wide association studies (GWAS). Transcriptome-wide association studies (TWAS) can both prior…
View article: Neuroprotective effect of ketamine against TNF‐α‐induced necroptosis in hippocampal neurons
Neuroprotective effect of ketamine against TNF‐α‐induced necroptosis in hippocampal neurons Open
Tumour necrosis factor‐α (TNF‐α), a crucial cytokine, has various homeostatic and pathogenic bioactivities. The aim of this study was to assess the neuroprotective effect of ketamine against TNF‐α‐induced motor dysfunction and neuronal nec…
View article: Osteoarthritis of the Temporomandibular Joint can be diagnosed earlier using biomarkers and machine learning
Osteoarthritis of the Temporomandibular Joint can be diagnosed earlier using biomarkers and machine learning Open
After chronic low back pain, Temporomandibular Joint (TMJ) disorders are the second most common musculoskeletal condition affecting 5 to 12% of the population, with an annual health cost estimated at $4 billion. Chronic disability in TMJ o…
View article: Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling
Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling Open
Vagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS’ role in cardiomyocyte phenotype, sarcomere organization, and ene…
View article: Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4+/Nanog+ NSCLC cells
Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4+/Nanog+ NSCLC cells Open
Cancer drug resistance and epithelial-mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, have recently been associated with the existence of cancer stem cells (CSCs). However, there are no appropriate CSC-m…
View article: Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells
Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells Open
Streptomyces-derived natural products have been become a major focus of anti-tumor drug discovery studies. Neoantimycin F (NAT-F), was isolated from Streptomyces conglobatus by our group. Here, we examined the anti-cancer activities and it…