Hongshan Ge
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View article: Identifying critical windows of air pollution exposure and semen quality: A cross-sectional study in Chinese fertile men
Identifying critical windows of air pollution exposure and semen quality: A cross-sectional study in Chinese fertile men Open
In both the single pollutant models and the multi-pollutants models, PM2.5 and its chemical components inversely correlated with sperm motility in a relatively early window (from week 10 to week 11 before semen collection) which was identi…
View article: Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction Open
Hyperandrogenism in PCOS promotes ovarian inflammation by upregulating nuclear YAP, disrupting the inflammatory microenvironment, leading to abnormal ovarian pyroptosis, and ultimately impairing follicular function.
View article: The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study
The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study Open
Background The debate over the clinical role of atosiban in assisted reproduction continues. The purpose of our study was to explore the efficacy of atosiban on pregnancy outcomes of patients undergoing frozen embryo transfer. Methods A to…
View article: A cohort study on the association between metabolic/inflammatory status and pregnancy complications in PCOS patients after IVF/ICSI treatment
A cohort study on the association between metabolic/inflammatory status and pregnancy complications in PCOS patients after IVF/ICSI treatment Open
This study aims to explore the impact of insulin resistance and metabolic abnormalities on metabolic changes, inflammatory responses, and pregnancy complications during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI…
View article: Effect of Male Age on Semen Quality
Effect of Male Age on Semen Quality Open
Infertility is a global health problem that affects about 15% of couples of reproductive ages, and male factors contribute about 30–50% of these cases. Genetic and lifestyle factors were previously identified as causes of male infertility;…
View article: piR-38,736 promotes gastric cancer cell proliferation by downregulating SMAD4 expression
piR-38,736 promotes gastric cancer cell proliferation by downregulating SMAD4 expression Open
PIWI-interacting RNAs (piRNAs) play an important role in cancer development and progression. Although recent studies had advanced our understanding of the functions of various piRNAs in cancer, the specific role of piR-38736 in gastric can…
View article: Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermia
Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermia Open
Autophagy is regarded as an essential process for maintaining cell homeostasis. However, its role in the regulation of sperm motility is still less understood. In this study, we found that mitochondrial oxidative species (mROS) levels were…
View article: From Environmental Exposure Risk to Epigenetic Factors: What Role Do They Play in the Etiology of Endometriosis?
From Environmental Exposure Risk to Epigenetic Factors: What Role Do They Play in the Etiology of Endometriosis? Open
Endometriosis is defined as the ectopic growth of endometrium-like tissue. It brings pain and infertility to approximately 6–10% of women who are in reproductive age. The pathogenesis of endometriosis is still unclear, which also leads to …
View article: <i>CISD2</i> regulates oxidative stress and mitophagy to maintain the balance of the follicular microenvironment in PCOS
<i>CISD2</i> regulates oxidative stress and mitophagy to maintain the balance of the follicular microenvironment in PCOS Open
Inhibition of CISD2 can improve the occurrence of oxidative stress by increasing the level of mitophagy, thus affecting the occurrence and development of PCOS diseases.
View article: Sphingosine Phosphate Enhances Primordial Follicle Activation via LATS Inhibition in the Hippo Signaling Pathway
Sphingosine Phosphate Enhances Primordial Follicle Activation via LATS Inhibition in the Hippo Signaling Pathway Open
Background We investigated whether the large kinase tumor suppressor (LATS) blocker sphingosine phosphate (S1P) can influence the maintenance/activation of primordial follicle dormancy and examined the role of the Hippo-YAP pathway in the …
View article: Evaluation of microRNA expression profiles in human sperm frozen using permeable cryoprotectant-free droplet vitrification and conventional methods
Evaluation of microRNA expression profiles in human sperm frozen using permeable cryoprotectant-free droplet vitrification and conventional methods Open
For sperm cryopreservation, the conventional method, which requires glycerol, has been used for a long time. In addition, the permeable cryoprotectant-free vitrification method has been continuously studied. Although the differences of cry…
View article: Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome
Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome Open
Background For women of childbearing age, the biggest problem caused by polycystic ovary syndrome (PCOS) is infertility, which is mainly caused by anovulation, abnormal follicular development, proliferation of small antral follicles, and c…
View article: Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia Open
Hyperandrogenemia and persistent chronic inflammation, two main striking features of polycystic ovary syndrome (PCOS), have been proven involved in follicular dysgenesis in PCOS. However, the association between hyperandrogenism and inflam…
View article: The role of serum vitamin D in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle
The role of serum vitamin D in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle Open
Background The debate over the impact of vitamin D in assisted reproduction continues. The purpose of our study was to assess embryo quality and pregnancy outcomes among groups with different levels of vitamin D after the first in vitro fe…
View article: Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome
Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome Open
Background For women of childbearing age, the biggest problem caused by PCOS is infertility, which is mainly caused by anovulation, abnormal follicular development, proliferation of small antral follicles and the appearance of cystic folli…
View article: Exosomal lncRNA ATB Derived from Ovarian Cancer Cells Promotes Angiogenesis via Regulating miR-204-3p/TGF&amp;beta;R2 Axis
Exosomal lncRNA ATB Derived from Ovarian Cancer Cells Promotes Angiogenesis via Regulating miR-204-3p/TGF&beta;R2 Axis Open
Donglan Yuan,1,&ast; Ting Guo,2,&ast; DanDan Zhu,1 Hongshan Ge,1 Yinling Zhao,1 Aihua Huang,1 Xiaosu Wang,1 Xiuhong Cao,3 CuiQin He,1 Hua Qian,1 Hong Yu4 1Department of Obstetrics and Gynecology, Taizhou Peopleâs Hospital Affilia…
View article: Cyclosporine A to Treat Unexplained Recurrent Spontaneous Abortions: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Single-Center Trial
Cyclosporine A to Treat Unexplained Recurrent Spontaneous Abortions: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Single-Center Trial Open
This is the first randomized controlled trial to evaluate the clinical and immunomodulatory effects of CsA on the pregnancy outcomes of women with URSA and our results will provide evidence to evaluate the use of CsA as a treatment for wom…
View article: LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation (Supplementary Table-1.docx)
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation (Supplementary Table-1.docx) Open
Myoblast differentiation is a crucial process for myogenesis. Mitochondria function as an energy-providing machine that is critical to this process, and mitochondrial dysfunction can prevent myoblasts from fusing into myotubes. However, th…
View article: Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation
Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation Open
We conducted this study for the purpose of evaluating the protective mechanisms of curcumin against oxidative stress in asthenozoospermic individuals. Asthenozoospermic individuals were grouped into AS group, curcumin treatment group and b…
View article: Overexpression of miR‑148a inhibits viability and invasion of ovarian cancer OVCAR3 cells by targeting FOXO3
Overexpression of miR‑148a inhibits viability and invasion of ovarian cancer OVCAR3 cells by targeting FOXO3 Open
Decreased expression of microRNA (miR)-148a is associated with poor prognosis in ovarian cancer. The aim of the present study was to investigate the impact of miR-148a on tumor cell viability and invasion via targeting forkhead box protein…
View article: Yap regulates mitochondrial structural remodeling during myoblast differentiation
Yap regulates mitochondrial structural remodeling during myoblast differentiation Open
Yes-associated protein (Yap) is a core transcriptional coactivator in the downstream Hippo pathway that regulates cell proliferation and tissue growth. However, its role in the regulation of myoblast differentiation remains unclear. Regula…
View article: UCP2 Mitigates the Loss of Human Spermatozoa Motility by Promoting mROS Elimination
UCP2 Mitigates the Loss of Human Spermatozoa Motility by Promoting mROS Elimination Open
Background/Aims: To demonstrate the function of uncoupling protein 2 (UCP2) in the regulation of human spermatozoa motility. Methods: Semen samples were collected from donors with either normal spermatozoa motility (normospermia [NS]) or p…
View article: A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis
A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis Open
Cadmium is an endocrine disruptor, impairing male reproduction. The objective of this study is to investigate whether cadmium affects rat Leydig cell regeneration and to dissect the underlying mechanism. Adult male Sprague-Dawley rats rece…
View article: Leukemia inhibitory factor stimulates steroidogenesis of rat immature Leydig cells via increasing the expression of steroidogenic acute regulatory protein
Leukemia inhibitory factor stimulates steroidogenesis of rat immature Leydig cells via increasing the expression of steroidogenic acute regulatory protein Open
Leukemia inhibitory factor (LIF) has many physiological roles. However, its effects on Leydig cell development are still unclear. Rat immature and adult Leydig cells were cultured with different concentrations of LIF alone or in combinatio…
View article: Regulation of development of rat stem and progenitor Leydig cells by activin
Regulation of development of rat stem and progenitor Leydig cells by activin Open
Summary Stem Leydig cells have been demonstrated to differentiate into adult Leydig cells via intermediate stages of progenitor and immature Leydig cells. However, the exact regulatory mechanisms are unclear. We hypothesized that the devel…