Hongtao Lan
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View article: PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications
PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications Open
View article: PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications
PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications Open
Hypertension is a multifactorial condition influenced by both genetic and environmental factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to increased blood pressure.…
View article: Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI–GRP94–GPIIb/IIIa Pathway in Mice
Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI–GRP94–GPIIb/IIIa Pathway in Mice Open
Aims: Deep vein thrombosis (DVT) is a prevalent cardiovascular condition. Endothelial-derived extracellular vesicles (EVs) may play a crucial role in platelet-dependent DVT development via platelet activation, but the mechanism is not clea…
View article: Humic Acids Inhibit Platelet Activation to Reduce Venous Thromboembolism in Mice
Humic Acids Inhibit Platelet Activation to Reduce Venous Thromboembolism in Mice Open
Objective. We aimed to investigate the effects of the natural product humic acids (HA) on platelet activation and development of venous thromboembolism (VTE) in mice and further explore the relevant mechanism. Methods. Eight-week C57BL/6 m…
View article: Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism
Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism Open
We anticipate that the miR-200a-5p-COX7C pair might be involved in the progression of VTE. Moreover, miR-200a-5p might be a therapeutic target for VTE.
View article: PGF2<i>α</i>‐FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI‐1 Signal Pathway
PGF2<i>α</i>‐FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI‐1 Signal Pathway Open
Senescence in vascular smooth muscle cells (VSMCs) is involved in vascular remodeling of aged mice. ProstaglandinF2 α- (PGF2 α ‐) FP receptor plays a critical role in cardiovascular diseases (CVDs), hypertension, and cardiac fibrosis. Howe…
View article: Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease
Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease Open
In diabetic patients with CHD, platelet activation was significantly high. Diabetes and heart rate <60 bpm were associated with elevated EMPs and simultaneously increased PDI activity on EMP, activating platelets through the allosteric GPI…
View article: Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome
Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome Open
Background The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide …
View article: Cross-talk between ANGPTL4 gene SNP rs1044250 and weight management is a risk factor of Mets
Cross-talk between ANGPTL4 gene SNP rs1044250 and weight management is a risk factor of Mets Open
Background The prevalence of metabolic syndrome (Mets) is closely related to the increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide…